YAF2 - YY1 associated factor 2 Gene

Homo sapiens

Gene ID: 10138 | Gene type: protein coding

About YAF2

Cytogenetic location: 12q12 Genomic coordinates (GRCh38): 12:42,157,104-42,238,248 (from NCBI)

This gene has 19 transcripts (splice variants), 120 orthologues and 1 paralogue. Ubiquitous expression in heart (RPKM 3.8), brain (RPKM 3.3) and 25 other tissues.

Summary

This gene encodes a zinc finger containing protein that functions in the regulation of transcription. This protein was identified as an interacting partner of transcriptional repressor protein Yy1, and also interacts with Other transcriptional regulators, including Myc and Polycomb. This protein can promote proteolysis of Yy1. Multiple alternatively spliced transcript variants have been found. [provided by RefSeq, Feb 2016]

YAF2 Products(5)

mRNA	Protein	Name
NM_001190977.3	NP_001177906.1	YY1-associated factor 2 isoform 3
NM_001190979.3	NP_001177908.1	YY1-associated factor 2 isoform 1
NM_001190980.3	NP_001177909.1	YY1-associated factor 2 isoform 4
NM_001320080.2	NP_001307009.1	YY1-associated factor 2 isoform 5
NM_005748.6	NP_005739.2	YY1-associated factor 2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	9016636	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	11593398	GOA
enables transcription corepressor activity	IDA IDA: Inferred from direct assay	12706874	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12706874	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	11593398	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	11593398	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

YAF2 Protein Structure

zf-RanBP

0
100
180 a.a.

Protein Preferred Names

Protein Names

YY1-associated factor 2

YAF2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	YAF2	Q8IY57	SETBP1	Homo sapiens	Q9Y6X0	Y2H Array	25416956
Intra	YAF2	Q8IY57	RING1	Homo sapiens	Q06587	TAP	27705803
Intra	YAF2	Q8IY57	RING1	Homo sapiens	Q06587	Y2H Array	25416956
Intra	YAF2	Q8IY57	RING1	Homo sapiens	Q06587	Anti Tag CoIP	33961781
Intra	YAF2	Q8IY57	RING1	Homo sapiens	Q06587	Y2H Prey Pooling	25416956
Intra	YAF2	Q8IY57	RING1	Homo sapiens	Q06587	Y2H	21516116

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Pontocerebellar Hypoplasia, Type 13

PCH13	Pontocerebellar Hypoplasia Type 13
Pontocerebellar Hypoplasia 13	Doid:0112332
Hypoplasia, Pontocerebellar, Type 13

Progressive Myoclonus Epilepsy 1b

Epm1b

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15910	YAF2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	YAF2	VGNC	VGNC:49709
Bos taurus	YAF2	VGNC	VGNC:37014
Macaca mulatta	YAF2	VGNC	VGNC:79076
Rattus norvegicus	YAF2	RGD	RGD:1582851
Felis catus	YAF2	VGNC	VGNC:67128
Mus musculus	YAF2	MGD	MGI:1914307

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