RING1 - ring finger protein 1 Gene

Homo sapiens

Also known as RNF1; RING1A

Gene ID: 6015 | Gene type: protein coding

About RING1

Cytogenetic location: 6p21.32 Genomic coordinates (GRCh38): 6:33,208,500-33,212,716 (from NCBI)

This gene has 2 transcripts (splice variants), 1 gene allele, 187 orthologues and 7 paralogues. Ubiquitous expression in endometrium (RPKM 22.9), ovary (RPKM 22.0) and 25 other tissues.

Summary

This gene belongs to the RING finger family, members of which encode proteins characterized by a RING domain, a zinc-binding motif related to the zinc finger domain. The gene product can bind DNA and can act as a transcriptional repressor. It is associated with the multimeric polycomb group protein complex. The gene product interacts with the polycomb group proteins BMI1, EDR1, and CBX4, and colocalizes with these proteins in large nuclear domains. It interacts with the CBX4 protein via its glycine-rich C-terminal domain. The gene maps to the HLA class II region, where it is contiguous with the RING finger genes FABGL and HKE4. [provided by RefSeq, Jul 2008]

RING1 Products(1)

mRNA	Protein	Name
NM_002931.4	NP_002922.2	E3 ubiquitin-protein ligase RING1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15386022	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in chromatin remodeling	IDA IDA: Inferred from direct assay	16943429	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	9199346	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of PRC1 complex	IDA IDA: Inferred from direct assay	12167701	GOA
part of PcG protein complex	IDA IDA: Inferred from direct assay	16943429	GOA
located in nucleus	IDA IDA: Inferred from direct assay	9199346	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RING1 Protein Structure

zf-C3HC4

0
100
200
300
406 a.a.

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase RING1

RING-type E3 ubiquitin transferase RING1

Related Diseases

Diseases

Alias

Granulomatosis With Polyangiitis

GPA	Wegener Granulomatosis
Wegener Granulomatosis, Formerly	Midline Granulomatosis
Wg, Formerly	Necrotizing Respiratory Granulomatosis
Wg	Wegeners Granulomatosis
Pauci-Immune Glomerulonephritis Associated With Granulomatosis With Polyangiitis

Juvenile-Onset Parkinson'S Disease

Juvenile-Onset Parkinson Disease

Lymphoma, Hodgkin, Classic

Hodgkin Lymphoma	Hodgkin Disease
Hodgkin'S Lymphoma	Hodgkins Lymphoma
Classic Hodgkin Lymphoma	CHL
Hodgkin Lymphoma, Susceptibility To	Hl
Hodgkin'S Sarcoma	Stage I Subdiaphragmatic Hodgkin Lymphoma
Stage Ii Subdiaphragmatic Hodgkin Lymphoma	Lymphoma, Hodgkin'S
Classic Hodgkin Disease	Hodgkin'S Disease
Lymphoma, Hodgkin, Susceptibility To	Hodgkin'S Disease Of Intrapelvic Lymph Nodes
Hodgkin'S Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb	Malignant Lymphogranuloma
Malignant Lymphogranulomatosis	Malignant Hodgkin Lymphoma
Classical Hodgkin Lymphoma, Type Not Specified

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-139514	RB-3	Inhibitor	99.42%	Unkown
HY-158239	MS181	Inhibitor	98.36%	Unkown
HY-103291	Sar-[D-Phe8]-des-Arg9-Bradykinin	Agonist	99.34%	Unkown
HY-RS11985	RING1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-116918	N,N-Diphenylacetamide		/	Unkown
HY-117664	PNR-7-02	Inhibitor	/	Unkown
HY-129665	GS-389	Inhibitor	/	Unkown
HY-138140	Desertomycin A		/	Unkown
HY-160562	PROTAC ERα Degrader-7	Degrader	/	Unkown
HY-160924	MS147	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	RING1	VGNC	VGNC:33977
Macaca mulatta	RING1	VGNC	VGNC:83457
Rattus norvegicus	RING1	RGD	RGD:3576
Mus musculus	RING1	MGD	MGI:1101770
Canis familiaris	RING1	VGNC	VGNC:45589
Others	RING1	NCBI

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