ALYREF - Aly/REF export factor Gene

Homo sapiens

Also known as ALY; BEF; REF; THOC4; ALY/REF

Gene ID: 10189 | Gene type: protein coding

About ALYREF

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:81,887,835-81,891,587 (from NCBI)

This gene has 4 transcripts (splice variants), 170 orthologues and 2 paralogues. Ubiquitous expression in bone marrow (RPKM 44.1), testis (RPKM 33.0) and 25 other tissues.

Summary

The protein encoded by this gene is a heat stable, nuclear protein and functions as a molecular chaperone. It is thought to regulate dimerization, DNA binding, and transcriptional activity of basic region-leucine zipper (bZIP) proteins. [provided by RefSeq, Jul 2008]

ALYREF Products(1)

mRNA	Protein	Name
NM_005782.4	NP_005773.3	THO complex subunit 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables C5-methylcytidine-containing RNA reader activity	IDA IDA: Inferred from direct assay	28418038	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11546874	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in RNA export from nucleus	IDA IDA: Inferred from direct assay	28418038	GOA
involved in mRNA export from nucleus	IMP IMP: Inferred from mutant phenotype	17190602	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of catalytic step 2 spliceosome	IDA IDA: Inferred from direct assay	11991638	GOA
colocalizes with chromosome, telomeric region	IDA IDA: Inferred from direct assay	24270157	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	28418038	GOA
part of exon-exon junction complex	IDA IDA: Inferred from direct assay	16314458	GOA
located in nucleus	IDA IDA: Inferred from direct assay	28418038	GOA
part of transcription export complex	IDA IDA: Inferred from direct assay	15833825	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ALYREF Protein Structure

RRM_1

FoP_duplication

0
100
200
257 a.a.

Protein Preferred Names

Protein Names

THO complex subunit 4

THO complex 4

ALYREF Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ALYREF	Q86V81	CHTOP	Homo sapiens	Q9Y3Y2	Anti Bait CoIP	23299939
Intra	ALYREF	Q86V81	CHTOP	Homo sapiens	Q9Y3Y2	Pull Down	23299939
Intra	ALYREF	Q86V81	CHTOP	Homo sapiens	Q9Y3Y2	Anti Tag CoIP	23299939
Intra	ALYREF	Q86V81	DDX39B	Homo sapiens	Q13838	Anti Bait CoIP	23299939
Intra	ALYREF	Q86V81	DDX39B	Homo sapiens	Q13838	Anti Tag CoIP	23299939
Intra	ALYREF	Q86V81	NXF1	Homo sapiens	Q9UBU9	Anti Tag CoIP	23299939
Intra	ALYREF	Q86V81	NXF1	Homo sapiens	Q9UBU9	Pull Down	23299939
Cross	ALYREF	Q86V81	mta_hhv8p	Human herpesvirus 8	Q2HR75	IF	19850040
Cross	ALYREF	Q86V81	mta_hhv8p	Human herpesvirus 8	Q2HR75	Pull Down	19850040

Cross: Cross-species interaction Intra: Intraspecies interaction

ALYREF Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82334	Aly Antibody (YA2079)	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat

Related Diseases

Diseases

Alias

Sarcoma

Connective And Soft Tissue Neoplasm	Tumor Of Soft Tissue And Skeleton
Sarcomas	Sarcoma - Category

Macular Dystrophy, Patterned, 3

Martinique Crinkled Retinal Pigment Epitheliopathy	Patterned Macular Dystrophy 3
MDPT3	Mcrpe

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Spinocerebellar Ataxia 8

Spinocerebellar Ataxia Type 8	SCA8
Ataxia, Spinocerebellar, Type 8

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00639	ALYREF Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ALYREF	VGNC	VGNC:37823
Rattus norvegicus	ALYREF	RGD	RGD:1594679
Felis catus	ALYREF	VGNC	VGNC:59762
Macaca mulatta	ALYREF	VGNC	VGNC:69635
Bos taurus	ALYREF	VGNC	VGNC:25855
Mus musculus	ALYREF	MGD	MGI:1341044

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