PSMD14 - proteasome 26S subunit, non-ATPase 14 Gene

Homo sapiens

Also known as PAD1; POH1; RPN11

Gene ID: 10213 | Gene type: protein coding

About PSMD14

Cytogenetic location: 2q24.2 Genomic coordinates (GRCh38): 2:161,308,425-161,411,717 (from NCBI)

This gene has 5 transcripts (splice variants), 211 orthologues and 3 paralogues. Ubiquitous expression in brain (RPKM 24.9), testis (RPKM 22.1) and 25 other tissues.

Summary

This gene encodes a component of the 26S Proteasome. The 26S Proteasome is a large multiprotein complex that catalyzes the degradation of ubiquitinated intracellular proteins. The encoded protein is a component of the 19S regulatory cap complex of the 26S Proteasome and mediates substrate deubiquitination. A pseudogene of this gene is also located on the long arm of chromosome 2. [provided by RefSeq, Feb 2012]

PSMD14 Products(1)

mRNA	Protein	Name
NM_005805.6	NP_005796.1	26S proteasome non-ATPase regulatory subunit 14

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables endopeptidase activator activity	IMP IMP: Inferred from mutant phenotype	18162577	GOA
enables metal-dependent deubiquitinase activity	IMP IMP: Inferred from mutant phenotype	22909820	GOA
enables proteasome binding	IDA IDA: Inferred from direct assay	18162577	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19615732	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in double-strand break repair via homologous recombination	IMP IMP: Inferred from mutant phenotype	22909820	GOA
involved in double-strand break repair via nonhomologous end joining	IMP IMP: Inferred from mutant phenotype	22909820	GOA
involved in protein K63-linked deubiquitination	IMP IMP: Inferred from mutant phenotype	22909820	GOA
involved in regulation of proteasomal protein catabolic process	IMP IMP: Inferred from mutant phenotype	18162577	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of proteasome complex	IDA IDA: Inferred from direct assay	17323924	GOA
part of proteasome regulatory particle, lid subcomplex	IMP IMP: Inferred from mutant phenotype	22909820	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PSMD14 Protein Structure

JAB

MitMem_reg

0
100
200
310 a.a.

Protein Preferred Names

Protein Names

26S proteasome non-ATPase regulatory subunit 14

26S proteasome regulatory subunit rpn11

PSMD14 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PSMD14	O00487	FAM9B	Homo sapiens	Q8IZU0	Y2H Prey Pooling	25416956
Intra	PSMD14	O00487	FAM9B	Homo sapiens	Q8IZU0	Validated Y2H	25416956
Intra	PSMD14	O00487	PSMD7	Homo sapiens	P51665	Y2H Prey Pooling	25416956
Intra	PSMD14	O00487	PSMD7	Homo sapiens	P51665	Y2H Prey Pooling	32296183
Intra	PSMD14	O00487	PSMD7	Homo sapiens	P51665	Y2H Array	25416956
Intra	PSMD14	O00487	PSMD7	Homo sapiens	P51665	Y2H Array	32296183
Intra	PSMD14	O00487	PSMD7	Homo sapiens	P51665	Validated Y2H	25416956
Intra	PSMD14	O00487	PSMD7	Homo sapiens	P51665	Anti Tag CoIP	26496610
Intra	PSMD14	O00487	PSMD7	Homo sapiens	P51665	Anti Tag CoIP	19615732
Intra	PSMD14	O00487	PSMD7	Homo sapiens	P51665	Validated Y2H	32296183
Intra	PSMD14	O00487	HTT	Homo sapiens	P42858	Validated Y2H	32814053
Intra	PSMD14	O00487	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
Intra	PSMD14	O00487	HTT	Homo sapiens	P42858	Y2H Array	32814053
Intra	PSMD14	O00487	DPY30	Homo sapiens	Q9C005	Validated Y2H	32296183
Intra	PSMD14	O00487	DPY30	Homo sapiens	Q9C005	Y2H Array	25416956
Intra	PSMD14	O00487	MEOX2	Homo sapiens	P50222	Y2H Array	25416956
Intra	PSMD14	O00487	MEOX2	Homo sapiens	P50222	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Cystic Fibrosis

Mucoviscidosis	CF
Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis	Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis
Cystic Fibrosis Lung Disease, Modifier Of	Cystic Fibrosis Of Pancreas
Fibrocystic Disease Of Pancreas	Cf - [Cystic Fibrosis]
Cystic Fibrosis Nos	Fibrocystic Disease
Fibrocystic Disease Of The Pancreas	Mucoviscidosis Of Pancreas
Nonproliferative Fibrocystic Disease	Pancreatic Cystic Fibrosis

Angelman Syndrome

AS	Happy Puppet Syndrome
Happy Puppet Syndrome, Formerly	Puppetlike Syndrome

Machado-Joseph Disease

SCA3	MJD
Spinocerebellar Ataxia 3	Azorean Disease
Spinocerebellar Ataxia Type 3	Spinocerebellar Atrophy
Azorean Neurologic Disease	Spinopontine Atrophy
Nigrospinodentatal Degeneration	Spinocerebellar Atrophy Iii
Spinocerebellar Atrophy Type 3	Azorean Ataxia
Azorean Disease Of The Nervous System	Machado Disease
Nigro-Spino-Dentatal Degeneration With Nuclear Ophthalmoplegia	Disease, Machado-Joseph
Ataxia, Spinocerebellar

Autosomal Dominant Cerebellar Ataxia

Spinocerebellar Ataxia	Adca
Pierre Marie Cerebellar Ataxia	Ataxia, Spinocerebellar
Sca	Autosomal Dominant Spinocerebellar Ataxia
Spinocerebellar Ataxias

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11322	PSMD14 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PSMD14	MGD	MGI:1913284
Rattus norvegicus	PSMD14	RGD	RGD:1594532
Canis familiaris	PSMD14	VGNC	VGNC:45110
Felis catus	PSMD14	VGNC	VGNC:64415
Bos taurus	PSMD14	VGNC	VGNC:33465
Macaca mulatta	PSMD14	VGNC	VGNC:76269
Others	PSMD14	NCBI

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