GDF11 - growth differentiation factor 11 Gene

Homo sapiens

Also known as VHO; BMP11; BMP-11

Gene ID: 10220 | Gene type: protein coding

About GDF11

Cytogenetic location: 12q13.2 Genomic coordinates (GRCh38): 12:55,743,122-55,757,264 (from NCBI)

This gene has 2 transcripts (splice variants), 120 orthologues, 31 paralogues and is associated with 2 phenotypes. Ubiquitous expression in brain (RPKM 8.1), endometrium (RPKM 6.4) and 24 other tissues.

Summary

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of Smad Family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein plays a role in the development of the nervous and other organ systems, and may regulate aging. [provided by RefSeq, Aug 2016]

GDF11 Products(1)

mRNA	Protein	Name
NM_005811.5	NP_005802.1	growth/differentiation factor 11 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18596030	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in activin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	28257634	GOA
involved in positive regulation of SMAD protein signal transduction	IMP IMP: Inferred from mutant phenotype	28257634	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of protein-containing complex	IDA IDA: Inferred from direct assay	24019467	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GDF11 Protein Structure

TGFb_propeptide

TGF_beta

0
100
200
300
407 a.a.

Protein Preferred Names

Protein Names

growth/differentiation factor 11

GDF-11

Recombinant GDF11 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P700020AF	Animal-Free GDF-11/BMP-11 Protein, Human (His)	O95390 (N299-S407)	≥95%
HY-P70222Y	GDF-11/BMP-11 Protein, Human (HEK293, solution)	O95390 (N299-S407)	≥95%

Related Diseases

Diseases

Alias

Vertebral Hypersegmentation And Orofacial Anomalies

VHO

Orofacial Clefting Syndrome

Orofacial Clefting

Orofacial Cleft

Cleft, Orofacial

Aging

Cleft Lip With Or Without Cleft Palate

Tessier Cleft Number 1,2

Myostatin-Related Muscle Hypertrophy

Mslhp

Muscle Hypertrophy Syndrome

Sacral Defect With Anterior Meningocele

Caudal Regression Syndrome	Caudal Regression Sequence
Sacral Agenesis	Caudal Dysgenesis Syndrome
SDAM	Caudal Dysplasia Sequence
Caudal Dysplasia	Sacral Agenesis Syndrome
Sacral Regression Syndrome	Sacral Defect And Anterior Sacral Meningocele
Rudd Klimek Syndrome	Sirenomelia

Renal Hypodysplasia/Aplasia 1

Renal Agenesis	Renal Adysplasia
Renal Aplasia	RHDA1
Hereditary Renal Aplasia	Hra
Hereditary Urogenital Adysplasia	Hypodysplasia/Aplasia, Renal, Type 1
Congenital Absence Of Kidneys Syndrome	Congenital Absence Of Kidney
Aplastic Kidney

Osteoporosis

Postmenopausal Osteoporosis	Osteoporosis, Postmenopausal
Bone Mineral Density Quantitative Trait Locus	Bmnd
Osteoporosis, Involutional	Osteoporosis, Susceptibility To
Osteoporosis, Postmenopausal, Susceptibility	Bone Mineral Density Variation Qtl, Osteoporosis
OSTEOP	Involutional Osteoporosis
Senile Osteoporosis	Osteoporosis Postmenopausal
Bone Mineral Density, Quantitative Trait Locus	Osteoporosis, Senile
Idiopathic Osteoporosis	Bone Rarefaction Nos
Type 1 Osteoporosis

Cleft Palate, Isolated

Cleft Palate	Isolated Cleft Palate
CPI	Cp
Palatoschisis	Cleft Palate Isolated
Uranostaphyloschisis	Congenital Fissure Of Palate
Cleft Of Secondary Palate

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99720	Luspatercept	Inhibitor	98.92%	Unkown

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05351	GDF11 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	GDF11	VGNC	VGNC:62502
Bos taurus	GDF11	VGNC	VGNC:29300
Mus musculus	GDF11	MGD	MGI:1338027
Rattus norvegicus	GDF11	RGD	RGD:2673
Canis familiaris	GDF11	VGNC	VGNC:41159
Macaca mulatta	GDF11	VGNC	VGNC:82150

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