POP7 - POP7 homolog, ribonuclease P/MRP subunit Gene

Homo sapiens

Also known as RPP2; RPP20; 0610037N12Rik

Gene ID: 10248 | Gene type: protein coding

About POP7

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:100,706,121-100,707,486 (from NCBI)

This gene has 2 transcripts (splice variants) and 182 orthologues. Ubiquitous expression in prostate (RPKM 11.3), brain (RPKM 11.1) and 25 other tissues.

Summary

Enables ribonuclease P RNA binding activity. Contributes to ribonuclease P activity. Involved in tRNA 5'-leader removal. Located in nucleolus. Part of multimeric ribonuclease P complex and ribonuclease MRP complex. [provided by Alliance of Genome Resources, Apr 2022]

POP7 Products(1)

mRNA	Protein	Name
NM_005837.3	NP_005828.2	ribonuclease P protein subunit p20

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14715275	GOA
enables ribonuclease P RNA binding	IDA IDA: Inferred from direct assay	16723659	GOA
contributes to ribonuclease P activity	IDA IDA: Inferred from direct assay	30454648	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in tRNA 5'-leader removal	IDA IDA: Inferred from direct assay	16723659	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of multimeric ribonuclease P complex	IDA IDA: Inferred from direct assay	16723659	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	20215441	GOA
part of ribonuclease MRP complex	IDA IDA: Inferred from direct assay	16723659	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

POP7 Protein Structure

Rpp20

0
100
140 a.a.

Protein Preferred Names

Protein Names

ribonuclease P protein subunit p20

POP7 (processing of precursor, S. cerevisiae) homolog

Related Diseases

Diseases

Alias

Anauxetic Dysplasia 2

ANXD2

Loiasis

Loa Loa Filariasis	Mansonelliasis
African Eye Worm	Mansonella Perstans Infections
Mansonellosis	Eye Worm Disease Of Africa
Loa Loa Infestation	African Eyeworm Disease
Calabar Swelling

Anauxetic Dysplasia 1

Anauxetic Dysplasia	Spondylometaepiphyseal Dysplasia, Menger Type
Spondylometaepiphyseal Dysplasia, Anauxetic Type	Spondyloepimetaphyseal Dysplasia, Anauxetic Type
ANXD1	Anxd
Spondylometaepiphyseal Dysplasia Anauxetic Type	Spondylometaepiphyseal Dysplasia Menger Type
Ad	Spondyloepimetaphyseal Dysplasia, Menger Type
Dysplasia, Anauxetic, Type 1

Peroxisome Biogenesis Disorder 1b

Peroxisome Biogenesis Disorder	Infantile Refsum Disease
Infantile Phytanic Acid Storage Disease	PBD1B
Refsum Disease, Infantile	Adrenoleukodystrophy, Autosomal Neonatal
Ird	Mild Pbd-Zsd
Mild Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder	Pbd-Zsd
Peroxisome Biogenesis Disorder Spectrum	Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder
Autosomal Neonatal Adrenoleukodystrophy	Refsum Disease Infantile
Peroxisome Biogenesis Disorders	Peroxisome Biogenesis Disorder, Type 1b

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10878	POP7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	POP7	VGNC	VGNC:33166
Felis catus	POP7	VGNC	VGNC:64299
Macaca mulatta	POP7	VGNC	VGNC:76079
Rattus norvegicus	POP7	RGD	RGD:1306413
Mus musculus	POP7	MGD	MGI:1921347
Canis familiaris	POP7	VGNC	VGNC:44818

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