CNKSR1 - connector enhancer of kinase suppressor of Ras 1 Gene

Homo sapiens

Also known as CNK; CNK1

Gene ID: 10256 | Gene type: protein coding

About CNKSR1

Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38): 1:26,177,491-26,189,884 (from NCBI)

This gene has 14 transcripts (splice variants), 201 orthologues, 4 paralogues and is associated with 1 phenotype. Broad expression in skin (RPKM 7.6), thyroid (RPKM 6.2) and 20 other tissues.

Summary

This gene encodes a protein containing several motifs involved in protein-protein interaction, including PDZ, PH (Pleckstrin homology), and SAM (sterile alpha motif) domains. The encoded protein acts as a scaffold component for receptor tyrosine kinase signaling and may mediate crosstalk between different signaling pathways. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

CNKSR1 Products(3)

mRNA	Protein	Name
NM_001297647.2	NP_001284576.1	connector enhancer of kinase suppressor of ras 1 isoform 2
NM_001297648.2	NP_001284577.1	connector enhancer of kinase suppressor of ras 1 isoform 3
NM_006314.3	NP_006305.2	connector enhancer of kinase suppressor of ras 1 isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables protein-macromolecule adaptor activity	IDA IDA: Inferred from direct assay	14749388	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell cortex	IDA IDA: Inferred from direct assay	15075335	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CNKSR1 Protein Structure

SAM_1

CRIC_ras_sig

0
200
400
600
720 a.a.

Protein Preferred Names

Protein Names

connector enhancer of kinase suppressor of ras 1

CNK homolog protein 1

CNKSR1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CNKSR1	Q969H4	CYTH4	Homo sapiens	Q8WWE8	Y2H Prey Pooling	25416956
Intra	CNKSR1	Q969H4	CYTH4	Homo sapiens	Q8WWE8	Validated Y2H	25416956
Intra	CNKSR1	Q969H4	CYTH4	Homo sapiens	Q8WWE8	Y2H Array	25416956
Intra	CNKSR1	Q969H4	CYTH4	Homo sapiens	Q9UIA0	Y2H Array	31515488
Intra	CNKSR1	Q969H4	CYTH4	Homo sapiens	Q9UIA0	Validated Y2H	32296183
Intra	CNKSR1	Q969H4	CYTH3	Homo sapiens	O43739-2	Anti Tag CoIP	28514442
Intra	CNKSR1	Q969H4	TCAF1	Homo sapiens	Q9Y4C2-2	Validated Y2H	32296183
Intra	CNKSR1	Q969H4	CYTH2	Homo sapiens	Q99418	Validated Y2H	32296183
Intra	CNKSR1	Q969H4	CYTH2	Homo sapiens	Q99418	Anti Tag CoIP	33961781
Intra	CNKSR1	Q969H4	PIN1	Homo sapiens	Q13526	Y2H Prey Pooling	25416956
Intra	CNKSR1	Q969H4	CYTH3	Homo sapiens	O43739	Anti Tag CoIP	33961781
Intra	CNKSR1	Q969H4	CYTH3	Homo sapiens	O43739	Y2H Prey Pooling	25416956
Intra	CNKSR1	Q969H4	CYTH1	Homo sapiens	Q15438	Anti Tag CoIP	33961781
Intra	CNKSR1	Q969H4	CYTH1	Homo sapiens	Q15438	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02888	CNKSR1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CNKSR1	VGNC	VGNC:97254
Rattus norvegicus	CNKSR1	RGD	RGD:1311879
Mus musculus	CNKSR1	MGD	MGI:2670958
Canis familiaris	CNKSR1	VGNC	VGNC:39403
Macaca mulatta	CNKSR1	VGNC	VGNC:71222
Felis catus	CNKSR1	VGNC	VGNC:61017

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