2. Gene
  3. CNKSR1 - connector enhancer of kinase suppressor of Ras 1 Gene

CNKSR1 - connector enhancer of kinase suppressor of Ras 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as CNK; CNK1

Gene ID: 10256 | Gene type: protein coding

About CNKSR1

Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38): 1:26,177,491-26,189,884 (from NCBI)

This gene has 14 transcripts (splice variants), 201 orthologues, 4 paralogues and is associated with 1 phenotype. Broad expression in skin (RPKM 7.6), thyroid (RPKM 6.2) and 20 other tissues.

Summary

This gene encodes a protein containing several motifs involved in protein-protein interaction, including PDZ, PH (Pleckstrin homology), and SAM (sterile alpha motif) domains. The encoded protein acts as a scaffold component for receptor tyrosine kinase signaling and may mediate crosstalk between different signaling pathways. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

CNKSR1 Products(3)

mRNA Protein Name
NM_001297647.2 NP_001284576.1 connector enhancer of kinase suppressor of ras 1 isoform 2
NM_001297648.2 NP_001284577.1 connector enhancer of kinase suppressor of ras 1 isoform 3
NM_006314.3 NP_006305.2 connector enhancer of kinase suppressor of ras 1 isoform 1
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
enables protein-macromolecule adaptor activity IDA
IDA: Inferred from direct assay
14749388 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cell cortex IDA
IDA: Inferred from direct assay
15075335 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CNKSR1 Protein Structure

SAM_1

SAM_1: SAM domain (Sterile alpha motif) (6 - 67)

CRIC_ras_sig

CRIC_ras_sig: Connector enhancer of kinase suppressor of ras (78 - 162)

PH

PH: PH domain (406 - 502)

  • 0
  • 200
  • 400
  • 600
  • 720 a.a.
Protein Preferred Names Protein Names

connector enhancer of kinase suppressor of ras 1

CNK homolog protein 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02888 CNKSR1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus CNKSR1 VGNC VGNC:97254
Rattus norvegicus CNKSR1 RGD RGD:1311879
Mus musculus CNKSR1 MGD MGI:2670958
Canis familiaris CNKSR1 VGNC VGNC:39403
Macaca mulatta CNKSR1 VGNC VGNC:71222
Felis catus CNKSR1 VGNC VGNC:61017