CYTH3 - cytohesin 3 Gene

Homo sapiens

Also known as GRP1; ARNO3; PSCD3; cytohesin-3

Gene ID: 9265 | Gene type: protein coding

About CYTH3

Cytogenetic location: 7p22.1 Genomic coordinates (GRCh38): 7:6,161,779-6,272,624 (from NCBI)

This gene has 11 transcripts (splice variants), 293 orthologues and 15 paralogues. Ubiquitous expression in placenta (RPKM 22.7), fat (RPKM 21.0) and 23 other tissues.

Summary

This gene encodes a member of the PSCD (pleckstrin homology, Sec7 and coiled-coil domains) family. PSCD family members have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with Phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This encoded protein is involved in the control of Golgi structure and function, and it may have a physiological role in regulating ADP-ribosylation factor protein 6 (ARF) functions, in addition to acting on ARF1. [provided by RefSeq, Jul 2008]

CYTH3 Products(4)

mRNA	Protein	Name
NM_001367580.1	NP_001354509.1	cytohesin-3 isoform b
NM_001367581.1	NP_001354510.1	cytohesin-3 isoform c
NM_001367582.1	NP_001354511.1	cytohesin-3 isoform c
NM_004227.4	NP_004218.1	cytohesin-3 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables guanyl-nucleotide exchange factor activity	IDA IDA: Inferred from direct assay	9707577	GOA
enables phosphatidylinositol-3,4,5-trisphosphate binding	IDA IDA: Inferred from direct assay	9742223	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in Golgi vesicle transport	IMP IMP: Inferred from mutant phenotype	9707577	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	9742223	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	17398095	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CYTH3 Protein Structure

Sec7

0
100
200
314 a.a.

Protein Preferred Names

Protein Names

cytohesin-3

ARF nucleotide-binding site opener 3

CYTH3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CYTH3	O43739	CCDC120	Homo sapiens	Q96HB5-4	Validated Y2H	25416956
Intra	CYTH3	O43739	CCDC120	Homo sapiens	Q96HB5-4	Y2H Prey Pooling	25416956
Intra	CYTH3	O43739	SYCE1	Homo sapiens	Q8N0S2	Validated Y2H	25416956
Intra	CYTH3	O43739	CNKSR1	Homo sapiens	Q969H4	Validated Y2H	25416956
Intra	CYTH3	O43739	CNKSR1	Homo sapiens	Q969H4	Y2H Array	25416956
Intra	CYTH3	O43739	CNKSR1	Homo sapiens	Q969H4	Y2H Pooling	16189514

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Corneal Dystrophy, Posterior Amorphous

Posterior Amorphous Corneal Dystrophy	PACD
Chromosome 12q21.33 Deletion Syndrome	Posterior Amorphous Stromal Dystrophy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03502	CYTH3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CYTH3	VGNC	VGNC:69096
Mus musculus	CYTH3	MGD	MGI:1335107
Rattus norvegicus	CYTH3	RGD	RGD:620399
Macaca mulatta	CYTH3	VGNC	VGNC:71829
Bos taurus	CYTH3	VGNC	VGNC:58371
Canis familiaris	CYTH3	VGNC	VGNC:49080

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