1. Gene
  2. Cd276 - CD276 antigen Gene

Cd276 - CD276 antigen Gene

Mus musculus

Also known as B7h3; B7RP-2; 6030411F23Rik

Gene ID: 102657 | Gene type: protein coding

About Cd276

Summary

Enables identical protein binding activity and signaling receptor binding activity. Acts upstream of or within several processes, including positive regulation of osteoblast differentiation; regulation of T cell proliferation; and regulation of cytokine production. Located in external side of plasma membrane. Is expressed in several structures, including embryo endoderm; genitourinary system; hemolymphoid system; liver; and musculoskeletal system. Orthologous to human CD276 (CD276 molecule). [provided by Alliance of Genome Resources, Apr 2022]

Cd276 Products(1)

mRNA Protein Name
NM_133983.4 NP_598744.1 CD276 antigen precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
23583036 MGI
enables signaling receptor binding IDA
IDA: Inferred from direct assay
12055244 MGI
enables signaling receptor binding IMP
IMP: Inferred from mutant phenotype
12925852 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of T cell proliferation IDA
IDA: Inferred from direct assay
12925852 MGI
acts upstream of T cell proliferation IMP
IMP: Inferred from mutant phenotype
12925852 MGI
acts upstream of or within negative regulation of T cell proliferation IDA
IDA: Inferred from direct assay
12925852 MGI
acts upstream of or within negative regulation of T cell proliferation IMP
IMP: Inferred from mutant phenotype
12925852 MGI
acts upstream of or within negative regulation of inflammatory response IMP
IMP: Inferred from mutant phenotype
12925852 MGI
acts upstream of or within negative regulation of interleukin-2 production IDA
IDA: Inferred from direct assay
12925852 MGI
acts upstream of or within negative regulation of type II interferon production IDA
IDA: Inferred from direct assay
12925852 MGI
acts upstream of or within negative regulation of type II interferon production IMP
IMP: Inferred from mutant phenotype
12925852 MGI
acts upstream of or within positive regulation of T cell proliferation IMP
IMP: Inferred from mutant phenotype
16751379 MGI
acts upstream of or within positive regulation of bone mineralization IMP
IMP: Inferred from mutant phenotype
15317945 MGI
acts upstream of or within positive regulation of interleukin-2 production IMP
IMP: Inferred from mutant phenotype
16751379 MGI
acts upstream of or within positive regulation of osteoblast differentiation IMP
IMP: Inferred from mutant phenotype
15317945 MGI
acts upstream of or within regulation of immune response IMP
IMP: Inferred from mutant phenotype
12925852 MGI
Cellular Component GO Annotation Evidence Reference Source
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
12925852 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

CD276 antigen

B7 homolog 3

B7-H3

costimulatory molecule

Cd276 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
Cd276 Q8VE98 Cd276 Mus musculus Q8VE98
GMS
23583036
Intra
Cd276 Q8VE98 Cd276 Mus musculus Q8VE98 23583036
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant Cd276 Proteins

Cat. No. Product Name Accession Purity
HY-P7639 CD276/B7-H3 Protein, Mouse (HEK293, His) Q8VE98 (V29-F244) ≥95%

Orthologs Information

Species Symbol Source ID
Homo sapiens Cd276 NCBI NCBI:80381
Macaca fascicularis Cd276 NCBI NCBI:102131295
Rattus norvegicus Cd276 NCBI NCBI:315716