RAMP2 - receptor activity modifying protein 2 Gene

Homo sapiens

Gene ID: 10266 | Gene type: protein coding

About RAMP2

Cytogenetic location: 17q21.2 Genomic coordinates (GRCh38): 17:42,761,227-42,763,041 (from NCBI)

This gene has 6 transcripts (splice variants), 198 orthologues and 2 paralogues. Broad expression in lung (RPKM 58.9), fat (RPKM 57.7) and 22 other tissues.

Summary

The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (Calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an Adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP2) protein, CRLR functions as an Adrenomedullin receptor. The RAMP2 protein is involved in core glycosylation and transportation of Adrenomedullin receptor to the cell surface. [provided by RefSeq, Jul 2008]

RAMP2 Products(1)

mRNA	Protein	Name
NM_005854.3	NP_005845.2	receptor activity-modifying protein 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables adrenomedullin binding	IPI IPI: Inferred from physical interaction	22102369	GOA
enables adrenomedullin receptor activity	IPI IPI: Inferred from physical interaction	9620797	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9620797	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IPI IPI: Inferred from physical interaction	9620797	GOA
involved in adherens junction assembly	IDA IDA: Inferred from direct assay	18097473	GOA
involved in adrenomedullin receptor signaling pathway	IPI IPI: Inferred from physical interaction	9620797	GOA
involved in angiogenesis	IDA IDA: Inferred from direct assay	20596610	GOA
involved in bicellular tight junction assembly	IDA IDA: Inferred from direct assay	18097473	GOA
involved in calcium ion transport	IDA IDA: Inferred from direct assay	10882736	GOA
involved in negative regulation of endothelial cell apoptotic process	IDA IDA: Inferred from direct assay	18097473	GOA
involved in negative regulation of vascular permeability	IDA IDA: Inferred from direct assay	18097473	GOA
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	18097473	GOA
involved in protein localization to plasma membrane	IDA IDA: Inferred from direct assay	10882736	GOA
involved in protein transport	IDA IDA: Inferred from direct assay	9620797	GOA
involved in receptor internalization	IDA IDA: Inferred from direct assay	10882736	GOA
involved in vasculogenesis	IMP IMP: Inferred from mutant phenotype	16964401	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of adrenomedullin receptor complex	IDA IDA: Inferred from direct assay	9620797	GOA
located in cell surface	IDA IDA: Inferred from direct assay	14722252	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	10882736	GOA
colocalizes with plasma membrane	IDA IDA: Inferred from direct assay	9620797	GOA
part of receptor complex	IDA IDA: Inferred from direct assay	15613468	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAMP2 Protein Structure

RAMP

0
100
175 a.a.

Protein Preferred Names

Protein Names

receptor activity-modifying protein 2

CRLR activity-modifying protein 2

RAMP2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RAMP2	O60895	LCN2	Homo sapiens	P80188	Y2H Array	32296183
Intra	RAMP2	O60895	LCN2	Homo sapiens	P80188	Y2H Prey Pooling	32296183
Intra	RAMP2	O60895	LCN2	Homo sapiens	P80188	Validated Y2H	32296183
Intra	RAMP2	O60895	CIDEB	Homo sapiens	Q9UHD4	Y2H Prey Pooling	32296183
Intra	RAMP2	O60895	CIDEB	Homo sapiens	Q9UHD4	Validated Y2H	32296183
Intra	RAMP2	O60895	CIDEB	Homo sapiens	Q9UHD4	Y2H Array	32296183
Intra	RAMP2	O60895	CALCRL	Homo sapiens	Q16602	Crosslink	22102369
Intra	RAMP2	O60895	CALCRL	Homo sapiens	Q16602	X-Ray Diffraction	22102369
Intra	RAMP2	O60895	CALCRL	Homo sapiens	Q16602	Anti Tag CoIP	22102369
Intra	RAMP2	O60895	CALCRL	Homo sapiens	Q16602	GMS	22102369

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Pheochromocytoma

Pheochromocytoma, Susceptibility To	Phaeochromocytoma
Adrenal Gland Chromaffin Paraganglioma	Adrenal Gland Chromaffinoma
Adrenal Gland Paraganglioma	Adrenal Gland Pheochromocytoma
Chromaffin Paraganglioma Of The Adrenal Gland	Intraadrenal Paraganglioma
PCC	Chromaffin Cell Tumor
Medullary Chromaffinoma	Medullary Paraganglioma
Pheochromoblastoma	Pheochromocytomas
Chromaffin Cell Neoplasm	Pheochromocytoma, Malignant

Cartilage Cancer

Chondrogenic Neoplasm

Lutembacher'S Syndrome

Lutembacher Syndrome

Lutembacher'S Anomaly

Migraine With Or Without Aura 1

Migraine	Migraine With Or Without Aura, Susceptibility To, 1
Migraine Disorder	Migraine Variant
Migraines	Migraine Disorders
Mgr1	Mgau
Ma	Migraine With Or Without Aura
Classic Migraine	Common Migraine
Disorder, Migraine	Headache Migraine
Headache Migrainous	Migraine Headache
Migraine Syndrome	Headache Including Migraine
Migraine, Susceptibility To

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P1548A	β-CGRP, human TFA		99.17%	Unkown
HY-P1548	β-CGRP, human		98.17%	Unkown
HY-P1548B	β-CGRP, human acetate		/	Unkown
HY-RS11639	RAMP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	RAMP2	VGNC	VGNC:69231
Macaca mulatta	RAMP2	VGNC	VGNC:76653
Mus musculus	RAMP2	MGD	MGI:1859650
Bos taurus	RAMP2	VGNC	VGNC:33707
Rattus norvegicus	RAMP2	RGD	RGD:61872

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