2. Gene
  3. STAG1 - stromal antigen 1 Gene

STAG1 - stromal antigen 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as SA1; MRD47; SCC3A

Gene ID: 10274 | Gene type: protein coding

About STAG1

Cytogenetic location: 3q22.3 Genomic coordinates (GRCh38): 3:136,336,236-136,752,378 (from NCBI)

This gene has 10 transcripts (splice variants), 221 orthologues, 2 paralogues and is associated with 88 phenotypes. Ubiquitous expression in ovary (RPKM 10.7), endometrium (RPKM 9.9) and 25 other tissues.

Summary

This gene is a member of the SCC3 family and is expressed in the nucleus. It encodes a component of cohesin, a multisubunit protein complex that provides sister chromatid cohesion along the length of a chromosome from DNA replication through prophase and prometaphase, after which it is dissociated in preparation for segregation during anaphase. [provided by RefSeq, Jul 2008]

STAG1 Products(1)

mRNA Protein Name
NM_005862.3 NP_005853.2 cohesin subunit SA-1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
15855230 GOA
Biological Process GO Annotation Evidence Reference Source
involved in mitotic spindle assembly IMP
IMP: Inferred from mutant phenotype
11590136 GOA
Cellular Component GO Annotation Evidence Reference Source
located in chromatin IDA
IDA: Inferred from direct assay
16682347 GOA
part of cohesin complex IDA
IDA: Inferred from direct assay
11590136 GOA
located in mitotic spindle pole IDA
IDA: Inferred from direct assay
11590136 GOA
located in nuclear matrix IDA
IDA: Inferred from direct assay
11590136 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STAG1 Protein Structure

STAG

STAG: STAG domain (157 - 276)

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  • 1258 a.a.
Protein Preferred Names Protein Names

cohesin subunit SA-1

SCC3 homolog 1

STAG1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
STAG1 Q8WVM7 STAG2 Homo sapiens Q8N3U4
Anti Bait CoIP
29867216
Intra
STAG1 Q8WVM7 STAG2 Homo sapiens Q8N3U4
Anti Tag CoIP
35271311
Intra
STAG1 Q8WVM7 STAG2 Homo sapiens Q8N3U4
Crosslink
30021884
Intra
STAG1 Q8WVM7 PDS5A Homo sapiens Q29RF7
Anti Bait CoIP
17113138
Intra
STAG1 Q8WVM7 PDS5B Homo sapiens Q9NTI5
Anti Bait CoIP
29867216
Intra
STAG1 Q8WVM7 PDS5B Homo sapiens Q9NTI5
Anti Bait CoIP
17113138
Intra
STAG1 Q8WVM7 TERF1 Homo sapiens P54274
Pull Down
17962804
Intra
STAG1 Q8WVM7 TERF1 Homo sapiens P54274
Anti Tag CoIP
17962804
Intra
STAG1 Q8WVM7 TERF1 Homo sapiens P54274
Anti Bait CoIP
17962804
Intra
STAG1 Q8WVM7 SMC3 Homo sapiens Q9UQE7
Anti Bait CoIP
22885700
Intra
STAG1 Q8WVM7 SMC3 Homo sapiens Q9UQE7
Anti Bait CoIP
15855230
Intra
STAG1 Q8WVM7 SMC3 Homo sapiens Q9UQE7
Anti Bait CoIP
17962804
Intra
STAG1 Q8WVM7 SMC3 Homo sapiens Q9UQE7
Anti Tag CoIP
35271311
Intra
STAG1 Q8WVM7 SMC3 Homo sapiens Q9UQE7
Anti Bait CoIP
17112726
Intra
STAG1 Q8WVM7 SMC3 Homo sapiens Q9UQE7
Pull Down
17962804
Intra
STAG1 Q8WVM7 SMC3 Homo sapiens Q9UQE7
Anti Bait CoIP
29867216
Intra
STAG1 Q8WVM7 SMC3 Homo sapiens Q9UQE7
Anti Bait CoIP
17113138
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Intellectual Developmental Disorder, Autosomal Dominant 47

Mental Retardation, Autosomal Dominant 47

MRD47

Autosomal Dominant Intellectual Developmental Disorder 47

Autosomal Dominant Mental Retardation 47

Stag1-Related Intellectual Disability-Facial Dysmorphism-Gastroesophageal Reflux Syndrome
Cornelia De Lange Syndrome

De Lange Syndrome

Brachmann De Lange Syndrome

Brachmann-De Lange Syndrome

Cdls

Bdls

Typus Degenerativus Amstelodamensis
Amelogenesis Imperfecta, Type If

Amelogenesis Imperfecta Type 1f

AI1F

Amelogenesis Imperfecta, Hypoplastic Type If

Amelogenesis Imperfecta Type If

Amelogenesis Imperfecta Hypoplastic Type If

Amelogenesis Imperfecta 1f
Roberts-Sc Phocomelia Syndrome

Roberts Syndrome

Sc Phocomelia Syndrome

RBS

Long Bone Deficiencies Associated With Cleft Lip-Palate

Sc Pseudothalidomide Syndrome

Appelt-Gerken-Lenz Syndrome

Pseudothalidomide Syndrome

Tetraphocomelia-Cleft Palate Syndrome

Hypomelia Hypotrichosis Facial Hemangioma Syndrome

Roberts Syndrome/Sc Phocomelia

Roberts Tetraphocomelia Syndrome

Sc Syndrome

Sc Phocomelia

Sc Disease

Sc

Hemoglobin Sc Disease
Atrial Septal Defect 1

ASD1

Atrial Heart Septal Defect 1

Asd
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13866 STAG1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris STAG1 VGNC VGNC:46873
Felis catus STAG1 VGNC VGNC:82509
Rattus norvegicus STAG1 RGD RGD:1310744
Mus musculus STAG1 MGD MGI:1098658
Bos taurus STAG1 VGNC VGNC:35353
Macaca mulatta STAG1 VGNC VGNC:77901