TRAIP - TRAF interacting protein Gene

Homo sapiens

Also known as TRIP; SCKL9; RNF206

Gene ID: 10293 | Gene type: protein coding

About TRAIP

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:49,828,601-49,856,564 (from NCBI)

This gene has 11 transcripts (splice variants), 198 orthologues and is associated with 3 phenotypes. Broad expression in testis (RPKM 4.0), bone marrow (RPKM 2.3) and 23 other tissues.

Summary

This gene encodes a protein that contains an N-terminal RING finger motif and a putative coiled-coil domain. A similar murine protein interacts with TNFR-associated factor 1 (TRAF1), TNFR-associated factor 2 (TRAF2), and cylindromatosis. The interaction with TRAF2 inhibits TRAF2-mediated nuclear factor kappa-B, subunit 1 activation that is required for cell activation and protection against Apoptosis. [provided by RefSeq, Jul 2008]

TRAIP Products(1)

mRNA	Protein	Name
NM_005879.3	NP_005870.2	E3 ubiquitin-protein ligase TRAIP

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17474147	GOA
enables ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	17544371	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA damage response	IDA IDA: Inferred from direct assay	26711499	GOA
involved in negative regulation of tumor necrosis factor-mediated signaling pathway	IDA IDA: Inferred from direct assay	19151749	GOA
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	17544371	GOA
involved in replication fork processing	IDA IDA: Inferred from direct assay	26711499	GOA
involved in replication fork processing	IMP IMP: Inferred from mutant phenotype	27462463	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleolus	IDA IDA: Inferred from direct assay	27462463	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	30165463	GOA
located in site of DNA damage	IDA IDA: Inferred from direct assay	26711499	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRAIP Protein Structure

zf-RING_2

0
100
200
300
400
469 a.a.

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase TRAIP

RING-type E3 ubiquitin transferase TRAIP

TRAIP Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TRAIP	Q9BWF2	JPH3	Homo sapiens	Q8WXH2	Y2H Array	32814053
Intra	TRAIP	Q9BWF2	JPH3	Homo sapiens	Q8WXH2	Y2H Pooling	32814053
Intra	TRAIP	Q9BWF2	JPH3	Homo sapiens	Q8WXH2	Validated Y2H	32814053
Intra	TRAIP	Q9BWF2	MAPRE2	Homo sapiens	Q15555	Validated Y2H	25416956
Intra	TRAIP	Q9BWF2	MAPRE2	Homo sapiens	Q15555	Y2H Array	32296183
Intra	TRAIP	Q9BWF2	MAPRE2	Homo sapiens	Q15555	Y2H Prey Pooling	25416956
Intra	TRAIP	Q9BWF2	MAPRE2	Homo sapiens	Q15555	Y2H Prey Pooling	32296183
Intra	TRAIP	Q9BWF2	ccsb_9919	Homo sapiens	EBI-25847655	Y2H Array	32814053
Intra	TRAIP	Q9BWF2	UBE2K	Homo sapiens	P61086	Y2H Array	32814053
Intra	TRAIP	Q9BWF2	UBE2K	Homo sapiens	P61086	Y2H Pooling	32814053
Intra	TRAIP	Q9BWF2	UBE2K	Homo sapiens	P61086	Validated Y2H	32814053
Intra	TRAIP	Q9BWF2	MAPRE3	Homo sapiens	Q9UPY8	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Seckel Syndrome 9

SCKL9

Seckel Syndrome

Microcephalic Primordial Dwarfism	Bird-Headed Dwarfism
Harper'S Syndrome	Virchow-Seckel Dwarfism
Nanocephalic Dwarfism	Sckl
Seckel-Type Dwarfism

Inflammatory Bowel Disease 9

IBD9

Meier-Gorlin Syndrome 8

MGORS8

Deafness, Autosomal Dominant 70

DFNA70	Autosomal Dominant Nonsyndromic Deafness 70
Autosomal Dominant Deafness 70	Deafness, Autosomal Dominant, 70

Ruijs-Aalfs Syndrome

Progeroid Features-Hepatocellular Carcinoma Predisposition Syndrome

RJALS

Spiradenoma

Eccrine Spiradenoma	Benign Eccrine Spiradenoma
Eccrine Spiradenoma Of Skin	Es
Eccrine Spiradenoma, Benign

Isolated Growth Hormone Deficiency, Type Ia

Ighd Ia	Primordial Dwarfism
Isolated Growth Hormone Deficiency Type Ia	Sexual Ateleiotic Dwarfism
Pituitary Dwarfism I	IGHD1A
Illig-Type Growth Hormone Deficiency	Growth Hormone Deficiency, Isolated, Type Ia
Congenital Ighd Type Ia	Congenital Isolated Gh Deficiency Type Ia
Congenital Isolated Growth Hormone Deficiency Type Ia	Pituitary Dwarfism 1
Growth Hormone Deficiency, Isolated, Autosomal Recessive	Autosomal Recessive Isolated Growth Hormone Deficiency
Isolated Growth Hormone Deficiency Type 1a	Congenital Ighd
Congenital Isolated Gh Deficiency	Congenital Isolated Growth Hormone Deficiency
Growth Hormone Deficiency, Isolated Autosomal Recessive	Illig Type Growth Hormone Deficiency
Non-Acquired Isolated Growth Hormone Deficiency	Growth Hormone Deficiency, Isolated, 1a
Growth Hormone Deficiency Isolated Autosomal Recessive	Dwarfism, Primordial
Dwarfism

Brooke-Spiegler Syndrome

Cyld Cutaneous Syndrome	Spiegler-Brooke Syndrome
Familial Cylindromatosis	BRSS
Bss	Sbs
Multiple Familial Trichoepithelioma	Ancell-Spiegler Cylindromas
Familial Multiple Trichoepithelioma	Trichoepithelioma
Fc	Mft
Multiple Familial Trichoepitheliomas	Ccs
Turban Tumor Syndrome	Schilbach-Rott Syndrome
Eccrine Dermal Cylindroma	Familial Multiple Trichoepitheliomata

Meier-Gorlin Syndrome 1

Meier-Gorlin Syndrome	Ear, Patella, Short Stature Syndrome
Microtia, Absent Patellae, Micrognathia Syndrome	MGORS1
Eps	Ear-Patella-Short Stature Syndrome
Ear Patella Short Stature Syndrome	Microtia Absent Patellae Micrognathia Syndrome
Meier-Gorlin Syndrome, Type 1

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Fanconi Anemia, Complementation Group A

Fanconi Anemia	Fanconi Pancytopenia
Fanconi Anemia Complementation Group A	FANCA
Fa	Fanconi Panmyelopathy
Fanconi'S Anemia	Fanconi Anaemia
Fanconi'S Anaemia	Fanconi Hypoplastic Anemia
Estren-Dameshek Variant Of Fanconi Anemia	Estren-Dameshek Variant Of Fanconi Pancytopenia
Fanconi Anemia Estren-Dameshek Variant	Fanconis Anemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14978	TRAIP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TRAIP	MGD	MGI:1096377
Felis catus	TRAIP	VGNC	VGNC:66504
Macaca mulatta	TRAIP	VGNC	VGNC:82261
Bos taurus	TRAIP	VGNC	VGNC:36280
Canis familiaris	TRAIP	VGNC	VGNC:47772
Rattus norvegicus	TRAIP	RGD	RGD:1309761

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