1. Gene
  2. MAPRE2 - microtubule associated protein RP/EB family member 2 Gene

MAPRE2 - microtubule associated protein RP/EB family member 2 Gene

Homo sapiens

Also known as EB1; EB2; RP1; CSCSC2

Gene ID: 10982 | Gene type: protein coding

About MAPRE2

Cytogenetic location: 18q12.1-q12.2 Genomic coordinates (GRCh38): 18:34,977,027-35,143,470 (from NCBI)

This gene has 13 transcripts (splice variants), 216 orthologues, 2 paralogues and is associated with 3 phenotypes. Ubiquitous expression in brain (RPKM 59.8), heart (RPKM 31.4) and 24 other tissues.

Summary

The protein encoded by this gene shares significant homology to the adenomatous polyposis coli (APC) protein-binding EB1 gene family. This protein is a microtubule-associated protein that is necessary for spindle symmetry during mitosis. It is thought to play a role in the tumorigenesis of colorectal cancers and the proliferative control of normal cells. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]

MAPRE2 Products(4)

mRNA Protein Name
NM_001143826.3 NP_001137298.1 microtubule-associated protein RP/EB family member 2 isoform 2
NM_001143827.3 NP_001137299.1 microtubule-associated protein RP/EB family member 2 isoform 3
NM_001256420.2 NP_001243349.1 microtubule-associated protein RP/EB family member 2 isoform 4
NM_014268.4 NP_055083.1 microtubule-associated protein RP/EB family member 2 isoform 1
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
enables microtubule binding IDA
IDA: Inferred from direct assay
25490267 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Cellular Component GO Annotation Evidence Reference Source
located in focal adhesion IDA
IDA: Inferred from direct assay
25490267 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAPRE2 Protein Structure

CH

CH: Calponin homology (CH) domain (61 - 158)

EB1

EB1: EB1-like C-terminal motif (261 - 299)

  • 0
  • 100
  • 200
  • 300
  • 327 a.a.
Protein Preferred Names Protein Names

microtubule-associated protein RP/EB family member 2

APC-binding protein EB1

MAPRE2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
MAPRE2 Q15555 MAPRE1 Homo sapiens Q15691 32296183
Intra
MAPRE2 Q15555 MAPRE1 Homo sapiens Q15691 25416956
Intra
MAPRE2 Q15555 MAPRE1 Homo sapiens Q15691
TAP
27173435
Intra
MAPRE2 Q15555 MAPRE1 Homo sapiens Q15691 25416956
Intra
MAPRE2 Q15555 MAPRE1 Homo sapiens Q15691 25416956
Intra
MAPRE2 Q15555 CRTAC1 Homo sapiens Q9NQ79 32296183
Intra
MAPRE2 Q15555 CRTAC1 Homo sapiens Q9NQ79 32296183
Intra
MAPRE2 Q15555 CRTAC1 Homo sapiens Q9NQ79 25416956
Intra
MAPRE2 Q15555 CRTAC1 Homo sapiens Q9NQ79 32296183
Intra
MAPRE2 Q15555 PAXIP1 Homo sapiens Q6ZW49-2 25416956
Intra
MAPRE2 Q15555 PAXIP1 Homo sapiens Q6ZW49-2 25416956
Intra
MAPRE2 Q15555 PAXIP1 Homo sapiens Q6ZW49-2 25416956
Intra
MAPRE2 Q15555 LMO2 Homo sapiens P25791-3 32296183
Intra
MAPRE2 Q15555 LMO2 Homo sapiens P25791-3 32296183
Intra
MAPRE2 Q15555 RBM6 Homo sapiens P78332-2 32296183
Intra
MAPRE2 Q15555 RBM6 Homo sapiens P78332-2 32296183
Intra
MAPRE2 Q15555 TRAIP Homo sapiens Q9BWF2 31515488
Intra
MAPRE2 Q15555 TRAIP Homo sapiens Q9BWF2 32296183
Intra
MAPRE2 Q15555 TRAIP Homo sapiens Q9BWF2 32296183
Intra
MAPRE2 Q15555 TRAIP Homo sapiens Q9BWF2 32296183
Intra
MAPRE2 Q15555 TRAIP Homo sapiens Q9BWF2 25416956
Intra
MAPRE2 Q15555 TXN2 Homo sapiens Q99757 25416956
Intra
MAPRE2 Q15555 TXN2 Homo sapiens Q99757 32296183
Intra
MAPRE2 Q15555 TRAF1 Homo sapiens Q13077 32296183
Intra
MAPRE2 Q15555 TRAF1 Homo sapiens Q13077 27107012
Intra
MAPRE2 Q15555 TRAF1 Homo sapiens Q13077 27107012
Intra
MAPRE2 Q15555 TRAF1 Homo sapiens Q13077 25416956
Intra
MAPRE2 Q15555 TRAF1 Homo sapiens Q13077 32296183
Intra
MAPRE2 Q15555 TRAF1 Homo sapiens Q13077 25416956
Intra
MAPRE2 Q15555 MAPRE3 Homo sapiens Q9UPY8 16189514
Intra
MAPRE2 Q15555 MAPRE3 Homo sapiens Q9UPY8 32296183
Intra
MAPRE2 Q15555 MAPRE3 Homo sapiens Q9UPY8 32296183
Intra
MAPRE2 Q15555 MAPRE3 Homo sapiens Q9UPY8 33961781
Intra
MAPRE2 Q15555 MAPRE3 Homo sapiens Q9UPY8 32296183
Intra
MAPRE2 Q15555 LMO2 Homo sapiens P25791 25416956
Intra
MAPRE2 Q15555 LNX1 Homo sapiens Q8TBB1 32296183
Intra
MAPRE2 Q15555 DDIT4L Homo sapiens Q96D03 32296183
Intra
MAPRE2 Q15555 DDIT4L Homo sapiens Q96D03 32296183
Intra
MAPRE2 Q15555 DDIT4L Homo sapiens Q96D03 32296183
Intra
MAPRE2 Q15555 GAS2L2 Homo sapiens Q8NHY3 32296183
Intra
MAPRE2 Q15555 GAS2L2 Homo sapiens Q8NHY3 32296183
Intra
MAPRE2 Q15555 GAS2L2 Homo sapiens Q8NHY3 32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Skin Creases, Congenital Symmetric Circumferential, 2

CSCSC2

Symmetric Circumferential Skin Creases, Congenital, 2

Congenital Symmetric Circumferential Skin Creases 2

Multiple Benign Circumferential Skin Creases On Limbs

Ccsf

Circumferential Skin Creases, Kunze Type

Congenital Circumferential Skin Folds

Kunze-Riehm Syndrome

Kunze Riehm Syndrome

Michelin Tire Baby Syndrome

Autosomal Dominant Intellectual Developmental Disorder 8

Autosomal Dominant Non-Syndromic Intellectual Disability 8

Mental Retardation, Autosomal Dominant 8

Autosomal Dominant Mental Retardation 8

Mrd8

Skin Creases, Congenital Symmetric Circumferential, 1

Michelin Tire Baby Syndrome

CSCSC1

Skin Creases, Multiple Benign Ring-Shaped, Of Limbs

Circumferential Skin Creases, Kunze Type

Congenital Symmetric Circumferential Skin Creases 1

Circumferential Skin Creases Kunze Type

Symmetric Circumferential Skin Creases, Congenital, 1

Csc-Kt

Multiple Benign Ring-Shaped Skin Creases Of Limbs

Michelin-Tire Baby

Severe Congenital Neutropenia 6

Autosomal Recessive Severe Congenital Neutropenia Due To Jagn1 Deficiency

Scn6

Vexas Syndrome

VEXAS

Vexas Syndrome, Somatic

Vacuoles, E1 Enzyme, X-Linked, Autoinflammatory And Somatic Syndrome

Vacuoles, E1 Enzyme, X-Linked, Autoinflammatory, Somatic Syndrome

Vacuoles, E1 Enzyme, X-Linked, Autoinflammatory, Somatic

Simultanagnosia
Myelodysplastic Syndrome

Myelodysplastic Syndromes

Myelodysplasia

MDS

Myelodysplastic Syndrome Included

Myelodysplastic Syndrome, Susceptibility To, Included

Myelodysplastic Syndrome, Somatic

Myelodysplastic Syndrome, Susceptibility To

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Bos taurus MAPRE2 VGNC VGNC:31233
Macaca mulatta MAPRE2 VGNC VGNC:74656
Felis catus MAPRE2 VGNC VGNC:68180
Mus musculus MAPRE2 MGD MGI:106271
Rattus norvegicus MAPRE2 RGD RGD:1590736
Canis familiaris MAPRE2 VGNC VGNC:43010