1. Gene
  2. LANCL1 - LanC like glutathione S-transferase 1 Gene

LANCL1 - LanC like glutathione S-transferase 1 Gene

Homo sapiens

Also known as p40; GPR69A

Gene ID: 10314 | Gene type: protein coding

About LANCL1

Cytogenetic location: 2q34 Genomic coordinates (GRCh38): 2:210,431,251-210,477,584 (from NCBI)

This gene has 8 transcripts (splice variants), 208 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 58.9), testis (RPKM 27.8) and 24 other tissues.

Summary

This gene encodes a loosely associated peripheral membrane protein related to the LanC family of Bacterial membrane-associated proteins involved in the biosynthesis of antimicrobial Peptides. This protein may play a role as a peptide-modifying Enzyme component in eukaryotic cells. Previously considered a member of the G-protein-coupled receptor superfamily, this protein is now in the LanC family. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2008]

LANCL1 Products(3)

mRNA Protein Name
NM_001136574.2 NP_001130046.1 glutathione S-transferase LANCL1
NM_001136575.2 NP_001130047.1 glutathione S-transferase LANCL1
NM_006055.3 NP_006046.1 glutathione S-transferase LANCL1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables SH3 domain binding IPI
IPI: Inferred from physical interaction
19528316 GOA
enables glutathione binding IDA
IDA: Inferred from direct assay
19528316 GOA
enables low-density lipoprotein particle receptor binding IDA
IDA: Inferred from direct assay
15082773 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17500595 GOA
enables zinc ion binding IDA
IDA: Inferred from direct assay
19528316 GOA
Biological Process GO Annotation Evidence Reference Source
NOT involved in G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
10944443 GOA
Cellular Component GO Annotation Evidence Reference Source
NOT located in plasma membrane IDA
IDA: Inferred from direct assay
10944443 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LANCL1 Protein Structure

LANC_like

LANC_like: Lanthionine synthetase C-like protein (56 - 399)

  • 0
  • 100
  • 200
  • 300
  • 399 a.a.
Protein Preferred Names Protein Names

glutathione S-transferase LANCL1

40 kDa erythrocyte membrane protein

LANCL1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
LANCL1 O43813 BAIAP2L1 Homo sapiens Q9UHR4 32296183
Intra
LANCL1 O43813 BAIAP2L1 Homo sapiens Q9UHR4 32296183
Intra
LANCL1 O43813 BAIAP2L1 Homo sapiens Q9UHR4 32296183
Cross
LANCL1 O43813 Eps8 Mus musculus Q08509
SPR
19528316
Intra
LANCL1 O43813 HTT Homo sapiens P42858 32814053
Intra
LANCL1 O43813 HTT Homo sapiens P42858 32814053
Intra
LANCL1 O43813 HTT Homo sapiens P42858 32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Charcot-Marie-Tooth Disease, Axonal, Type 2e

Charcot-Marie-Tooth Disease Type 2

CMT2E

CMT2S

CMT2Y

Charcot-Marie-Tooth Disease Type 2e

Charcot-Marie-Tooth Disease Type 2y

Charcot-Marie-Tooth Disease Axonal Type 2s

Charcot-Marie-Tooth Disease, Axonal, Type 2s

Charcot-Marie-Tooth Disease, Type 2e

Hereditary Motor And Sensory Neuropathy Type 2

Charcot-Marie-Tooth Neuropathy, Type 2s

Charcot-Marie-Tooth Disease, Axonal, Autosomal Recessive, Type 2s

Charcot-Marie-Tooth Disease, Axonal, Type 2y

Charcot-Marie-Tooth Disease, Axonal, Autosomal Dominant, Type 2y

Charcot-Marie-Tooth Neuropathy, Type 2y

Charcot-Marie-Tooth Disease, Type 2y

Autosomal Dominant Charcot-Marie-Tooth Disease Type 2e

Charcot-Marie-Tooth Neuropathy Type 2e

Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Due To Vcp Mutation

Cmt2 Due To Vcp Mutation

Charcot-Marie-Tooth Disease Type 2s

Autosomal Dominant Charcot-Marie-Tooth Disease Type 2

Autosomal Dominant Axonal Charcot-Marie-Tooth Disease

Cmt2

Charcot-Marie-Tooth Neuropathy, Type 2e

Hereditary Motor And Sensory Neuropathy Guadalajara Neuronal Type

Hereditary Motor And Sensory Neuropathy Okinawa Type

Autosomal Dominant Axonal Charcot-Marie-Tooth Type 2y

Charcot-Marie-Tooth Neuropathy Type 2y

Autosomal Recessive Axonal Charcot-Marie-Tooth Type 2s

Charcot-Marie-Tooth Neuropathy Type 2s

Charcot-Marie-Tooth Type 2

Autosomal Dominant Charcot-Marie-Tooth Disease Type 2y

Charcot-Marie-Tooth Disease 2e

Charcot-Marie-Tooth Disease Axonal Type 2e

Charcot-Marie-Tooth Disease Neuronal Type 2e

Charcot-Marie-Tooth Disease 2s

Charcot-Marie-Tooth Neuropathy Axonal Type 2s

Charcot-Marie-Tooth Disease 2y

Charcot-Marie-Tooth Disease, Type 2

Hereditary Motor And Sensory-Neuropathy Type Ii

Overhydrated Hereditary Stomatocytosis

Ohs

Potassium Sodium Disorder Of Erythrocyte

OHST

Stomatocytosis I

Potassium-Sodium Disorder Of Erythrocyte

Stomatocytosisiohst

Hereditary, Overhydrated, Cation-Leak Stomatocytosis

Overhydrated Cation Leak Stomatocytosis

Stomatocytosis, Overhydrated Hereditary

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Mus musculus LANCL1 MGD MGI:1336997
Bos taurus LANCL1 VGNC VGNC:30783
Felis catus LANCL1 VGNC VGNC:68016
Macaca mulatta LANCL1 VGNC VGNC:104541
Canis familiaris LANCL1 VGNC VGNC:42580
Rattus norvegicus LANCL1 RGD RGD:69416