2. Gene
  3. BAIAP2L1 - BAR/IMD domain containing adaptor protein 2 like 1 Gene

BAIAP2L1 - BAR/IMD domain containing adaptor protein 2 like 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as IRTKS

Gene ID: 55971 | Gene type: protein coding

About BAIAP2L1

Cytogenetic location: 7q21.3-q22.1 Genomic coordinates (GRCh38): 7:98,291,650-98,401,090 (from NCBI)

This gene has 5 transcripts (splice variants), 277 orthologues and 2 paralogues. Broad expression in stomach (RPKM 26.9), colon (RPKM 14.1) and 19 other tissues.

Summary

This gene encodes a member of the IMD (IRSp53/MIM homology domain) family. Members of this family can be subdivided in two groups, the IRSp53-like and MIM-like, based on the presence or absence of the SH3 (Src homology 3) domain. The protein encoded by this gene contains a conserved IMD, also known as F-actin bundling domain, at the N-terminus, and a canonical SH3 domain near the C-terminus, so it belongs to the IRSp53-like group. This protein is the substrate for Insulin Receptor tyrosine kinase and binds to the small GTPase Rac. It is involved in signal transduction pathways that link deformation of the plasma membrane and remodeling of the actin Cytoskeleton. It also promotes actin assembly and membrane protrusions when overexpressed in mammalian cells, and is essential to the formation of a potent actin assembly complex during EHEC (Enterohemorrhagic Escherichia coli) pedestal formation. [provided by RefSeq, Oct 2009]

BAIAP2L1 Products(1)

mRNA Protein Name
NM_018842.5 NP_061330.2 brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables proline-rich region binding IDA
IDA: Inferred from direct assay
21098279 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21098279 GOA
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of actin filament polymerization IDA
IDA: Inferred from direct assay
21098279 GOA
involved in regulation of actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
19366662 GOA
Cellular Component GO Annotation Evidence Reference Source
colocalizes with actin cytoskeleton IDA
IDA: Inferred from direct assay
19366662 GOA
located in cytosol IDA
IDA: Inferred from direct assay
19366662 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BAIAP2L1 Protein Structure

IMD

IMD: IRSp53/MIM homology domain (16 - 236)

SH3_9

SH3_9: Variant SH3 domain (347 - 398)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 511 a.a.
Protein Preferred Names Protein Names

brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1

BAI1 associated protein 2 like 1

BAIAP2L1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Cross
BAIAP2L1 Q9UHR4 espF(U) Escherichia coli O157:H7 P0DJ89
ITC
21098279
Cross
BAIAP2L1 Q9UHR4 espF(U) Escherichia coli O157:H7 P0DJ89
Peptide Array
21098279
Cross
BAIAP2L1 Q9UHR4 espF(U) Escherichia coli O157:H7 P0DJ89
ITC
22921828
Cross
BAIAP2L1 Q9UHR4 espF(U) Escherichia coli O157:H7 P0DJ89
Y2H
22921828
Cross
BAIAP2L1 Q9UHR4 espF(U) Escherichia coli O157:H7 P0DJ89
NMR
21098279
Cross
BAIAP2L1 Q9UHR4 espF(U) Escherichia coli O157:H7 P0DJ89
NMR
22921828
Intra
BAIAP2L1 Q9UHR4 EPS8 Homo sapiens Q12929
NMR
22921828
Intra
BAIAP2L1 Q9UHR4 EPS8 Homo sapiens Q12929
Pull Down
22921828
Intra
BAIAP2L1 Q9UHR4 EPS8 Homo sapiens Q12929
ITC
22921828
Intra
BAIAP2L1 Q9UHR4 EPS8 Homo sapiens Q12929
Peptide Array
21098279
Intra
BAIAP2L1 Q9UHR4 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra
BAIAP2L1 Q9UHR4 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra
BAIAP2L1 Q9UHR4 BAIAP2 Homo sapiens Q9UQB8
Anti Tag CoIP
35271311
Intra
BAIAP2L1 Q9UHR4 BAIAP2 Homo sapiens Q9UQB8-6
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Dentatorubral-Pallidoluysian Atrophy

DRPLA

Naito-Oyanagi Disease

Haw River Syndrome

Myoclonic Epilepsy With Choreoathetosis

Nod

Ataxia, Chorea, Seizures, And Dementia

Dentatorubropallidoluysian Atrophy

Hrs

Naito Oyanagi Disease

Dentatorubral Pallidoluysian Atrophy

Dentatorubro-Pallidoluysian Atrophy

Myoclonic Epilepsies, Progressive

Atrophy, Pallidoluysian, Dentatorubral
Donohue Syndrome

Leprechaunism

Leprechaunism Syndrome

Donohue'S Syndrome

LEPRCH
Acanthosis Nigricans

Keratosis Nigricans

An
Type 2 Diabetes Mellitus

Insulin Resistance

NIDDM

Type 2 Diabetes

Diabetes Mellitus, Non-Insulin-Dependent

T2D

Noninsulin-Dependent Diabetes Mellitus

Diabetes Mellitus, Type Ii

Maturity-Onset Diabetes

Insulin Resistance, Severe, Digenic

Diabetes Mellitus, Type 2

Diabetes Mellitus, Noninsulin-Dependent

Diabetes Mellitus, Noninsulin-Dependent, Association With

Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Hypertension, Insulin Resistance-Related, Susceptibility To

Insulin Resistance, Susceptibility To

Non-Insulin-Dependent Diabetes Mellitus

Type Ii Diabetes Mellitus

Adult-Onset Diabetes Mellitus

Maturity-Onset Diabetes Mellitus

Diabetes Mellitus Type 2

Type Ii Diabetes

Type 2 Diabetes Mellitus, Susceptibility To

Diabetes, Type 2

Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 2, Susceptibility To

Diabetes Mellitus, Noninsulin-Dependent, 2

Diabetes Mellitus, Type Ii, Susceptibility To

Hypertension, Insulin Resistance-Related

Adult-Onset Diabetes

Aodm

Diabetes Mellitus, Adult-Onset

Diabetes Mellitus Type Ii

Diabetes Mellitus Type 2, Susceptibility To

Diabetes, Type Ii, Susceptibility To

Diabetes Type 2

Diabetes Mellitus

Adult Onset Diabetes

Maturity Onset Diabetes

Nonketotic Diabetes

Non-Insulin Dependent Diabetes Mellitus

T2dm - [Type 2 Diabetes Mellitus]

Niddm - [Non Insulin Dependent Diabetes Mellitus]

Dm2

Dm Type Ii

Diabetic Type 2

Insulin Requiring Type 2 Diabetes

Noninsulin Dependent Diabetes

Non-Insulin-Dependent Diabetes Mellitus Without Complications

Diabetes Due To Insulin Secretory Defect

Diabetes Mellitus Due To Insulin Secretory Defect

Non-Insulin-Dependent Diabetes Of The Young

Senile Diabetes

Nonketotic Hyperglycaemia

Stable Diabetes
Hypogonadotropic Hypogonadism 6 With Or Without Anosmia

HH6

Kallmann Syndrome 6

Kal6

Hypogonadotropic Hypogonadism, Type 6 With/Without Anosmia
Gestational Diabetes

Gestational Diabetes Mellitus

GDM

Diabetes Mellitus Arising In Pregnancy

Maternal Gestational Diabetes Mellitus

Diabetes Mellitus, Gestational

Diabetes Mellitus, Pregnancy Related

Diabetes, Pregnancy-Induced

Diabetes Gestational

Diabetes, Gestational

Diabetes Of Pregnancy

Gdm - [Gestational Diabetes Mellitus]

Gestational Diabetes Mellitus Nos

Gestational Diabetes Complicating Pregnancy, Childbirth, Or The Puerperium
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01354 BAIAP2L1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta BAIAP2L1 VGNC VGNC:70109
Felis catus BAIAP2L1 VGNC VGNC:60071
Rattus norvegicus BAIAP2L1 RGD RGD:1308452
Mus musculus BAIAP2L1 MGD MGI:1914148
Bos taurus BAIAP2L1 VGNC VGNC:26413
Canis familiaris BAIAP2L1 VGNC VGNC:38372