EMC8 - ER membrane protein complex subunit 8 Gene

Homo sapiens

Also known as NOC4; COX4NB; C16orf2; C16orf4; FAM158B

Gene ID: 10328 | Gene type: protein coding

About EMC8

Cytogenetic location: 16q24.1 Genomic coordinates (GRCh38): 16:85,778,624-85,799,544 (from NCBI)

This gene has 6 transcripts (splice variants), 208 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 7.1), testis (RPKM 6.1) and 25 other tissues.

Summary

Contributes to membrane insertase activity. Involved in protein insertion into ER membrane by stop-transfer membrane-anchor sequence and tail-anchored membrane protein insertion into ER membrane. Located in cytosol. Part of EMC complex. [provided by Alliance of Genome Resources, Apr 2022]

EMC8 Products(2)

mRNA	Protein	Name
NM_001142288.2	NP_001135760.1	ER membrane protein complex subunit 8 isoform 2
NM_006067.5	NP_006058.1	ER membrane protein complex subunit 8 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
contributes to membrane insertase activity	IMP IMP: Inferred from mutant phenotype	29809151	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in protein insertion into ER membrane by stop-transfer membrane-anchor sequence	IDA IDA: Inferred from direct assay	29242231	GOA
involved in protein insertion into ER membrane by stop-transfer membrane-anchor sequence	IMP IMP: Inferred from mutant phenotype	29809151	GOA
involved in tail-anchored membrane protein insertion into ER membrane	IDA IDA: Inferred from direct assay	29242231	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of EMC complex	IDA IDA: Inferred from direct assay	22119785	GOA
part of EMC complex	IPI IPI: Inferred from physical interaction	32439656	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	22119785	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EMC8 Protein Structure

UPF0172

0
100
210 a.a.

Protein Preferred Names

Protein Names

ER membrane protein complex subunit 8

COX4 neighbor

EMC8 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	EMC8	O43402	EMC2	Homo sapiens	Q15006	Anti Tag CoIP	35271311
Intra	EMC8	O43402	EMC2	Homo sapiens	Q15006	Anti Tag CoIP	32439656
Intra	EMC8	O43402	EMC2	Homo sapiens	Q15006	Validated Y2H	32296183
Intra	EMC8	O43402	EMC2	Homo sapiens	Q15006	Pull Down	22119785

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant EMC8 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77342	COX4NB Protein, Human (His)	O43402-1 (M1-C210)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04342	EMC8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	EMC8	VGNC	VGNC:72259
Canis familiaris	EMC8	VGNC	VGNC:40337
Rattus norvegicus	EMC8	RGD	RGD:1311219
Bos taurus	EMC8	VGNC	VGNC:28467
Mus musculus	EMC8	MGD	MGI:1343095

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