TLR6 - toll like receptor 6 Gene

Homo sapiens

Also known as CD286

Gene ID: 10333 | Gene type: protein coding

About TLR6

Cytogenetic location: 4p14 Genomic coordinates (GRCh38): 4:38,822,897-38,868,390 (from NCBI)

This gene has 2 transcripts (splice variants), 190 orthologues and 22 paralogues. Broad expression in appendix (RPKM 4.9), spleen (RPKM 4.1) and 20 other tissues.

Summary

The protein encoded by this gene is a member of the Toll-like Receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor functionally interacts with Toll-like Receptor 2 to mediate cellular response to Bacterial lipoproteins. A Ser249Pro polymorphism in the extracellular domain of the encoded protein may be associated with an increased of asthma is some populations.[provided by RefSeq, Jan 2011]

TLR6 Products(8)

mRNA	Protein	Name
XM_024453873.2	XP_024309641.1	toll-like receptor 6 isoform X1
XM_047449496.1	XP_047305452.1	toll-like receptor 6 isoform X1
XM_047449497.1	XP_047305453.1	toll-like receptor 6 isoform X1
XM_005262637.6	XP_005262694.1	toll-like receptor 6 isoform X1
XM_047449498.1	XP_047305454.1	toll-like receptor 6 isoform X1
XM_011513613.4	XP_011511915.1	toll-like receptor 6 isoform X1
NM_006068.5	NP_006059.2	toll-like receptor 6 precursor
NM_001394553.1	NP_001381482.1	toll-like receptor 6 precursor

TLR6 Protein Structure

LRR_8

LRRCT

TIR

0
200
400
600
796 a.a.

Protein Preferred Names

Protein Names

toll-like receptor 6

Related Diseases

Diseases

Alias

Anaerobic Pneumonia

Pneumonia Due To Anaerobes

Cutis Laxa, Autosomal Dominant 2

ADCL2	Autosomal Dominant Cutis Laxa 2
Cutis Laxa, Autosomal Dominant, 2	Cutis Laxa, Autosomal Dominant, Type 2

Filariasis

Disease Due To Superfamily Filarioidea	Bancroftian Filarial Fever
Mumu	Wanganga
Bancroftian Filariasis	Wuchereriosis
Brugiosis	Malayan Filariasis

Filarial Elephantiasis

Lymphatic Filariasis	Elephantiasis
Filariasis	Bancroftian Elephantiasis
Bancroftian Filarial Chyluria	Elephantiasis Of Eyelid
Bancroftian Filariasis	Elephantitis
Malayi Tropical Eosinphilia	Wuchereria Bancrofti Infection
Wuchereriasis	Elephantiasis, Filarial
Filarial Elephantiases	Infection By Wuchereria Bancrofti
Filarial Lymphangitis	Tropical Elephantiasis
Filarial Chylocele

Malaria

Malaria, Susceptibility To	Malaria, Resistance To
Malaria, Cerebral	Cerebral Malaria
Malaria, Severe, Susceptibility To	Malaria, Severe, Resistance To
Malaria, Cerebral, Susceptibility To	Induced Malaria
Malaria, Vivax, Protection Against	Malaria, Severe
Malaria, Cerebral, Reduced Risk Of	Malaria, Protection Against
Resistance To Malaria Due To G6pd Deficiency	Malaria Due To G6pd Deficiency
Malarial Encephalitis	CM
Malaria Cerebral	Susceptibility To Malaria
Acute Pernicious Fever	Aestivo-Autumnal Fever
Aestivo Autumnal Malaria	Chagres Fever
Continued Malaria Fever	Estivo-Autumnal Fever
Estivo-Autumnal Malaria	Estivo-Autumnal Malarial Fever
Falciparum Fever	Malignant Tertian Fever
Malignant Tertian Malaria	Pernicious Intermittent Fever
Pernicious Malaria	Quotidian Malaria
Subtertian Fever	Subtertian Malaria Fever
Subtertian Malignant Tertian Malaria	Tropical Malaria
Algid Malaria	Bilious Haemoglobinuric Fever
Black Water Fever	Blackwater Fever
Malarial Blackwater Fever	Severe Malarial Falciparum
West African Fever	Malarial Haematinuria
Haemoglobinuric Fever	Haemoglobinuric Malaria
Severe Plasmodium Falciparum Malaria	Malarial Haemoglobinuria
Malarial Haematuria	Falciparum Malaria [Malignant Tertian]
Malaria Tropica	Malarial Shock
Chagres Virus Disease	Malignant Malaria
Mtm - [Malignant Tertian Malaria]	Tm -[Malignant Tertian Malaria]
Panama Fever	St - [Subtertian Malaria]
Malarial Quotidian	Benign Tertian Malaria
Tertian Ague	Vivax Fever
Plasmodium Vivax Malaria Nos	Btm - [Benign Tertian Malaria]
Bt - [Benign Tertian Malaria]	Vivax Malaria
Benign Tertian Vivax Malaria	Tertian Malaria
Quartan Malaria	Quartan Ague
Quartan Fever	Plasmodium Malariae Malaria Nos
Quartan Malarial	Malaria By Plasmodium Malariae
Malariae Malaria	Ovale Tertian Malaria
Plasmodium Ovale Fever	Malaria Fever By Plasmodium Ovale
Ovale Malaria	Malaria By Plasmodium Ovale
Malarial Ovale	Marsh Fever
Remittent Congestive Fever	Coastal Fever
Remittent Gastric Fever	Miasmatic Fever
Congestive Remittent Fever	Intermittent Fever
Jungle Fever	Paludism
Cameroon Fever	Ague
Corsican Fever	Intermittent Bilious Fever
Disease Due To Plasmodiidae	Malarial Fever
Plasmodiosis	Remittent Fever
Roman Fever	Malaria Fever Nos
Malaria Nos	Paludal Fever
Clinically Diagnosed Malaria	Clinically Diagnosed Malaria Without Parasitological Confirmation
Congestive Fever	Malarial Cachexia
Marsh Cachexia	Paludal Cachexia
Recurrent Malaria	Remittent Malaria

Cutis Laxa, Autosomal Dominant 3

ADCL3	Autosomal Dominant Cutis Laxa 3
Cutis Laxa, Autosomal Dominant, 3

Multisystem Inflammatory Syndrome In Children

Mis-C	Multisystem Inflammatory Disorder In Children And Adolescents
Paediatric Inflammatory Multisystemic Syndrome	Mic

Aspergillosis

Aspergillosis, Susceptibility To	Infection Due To Aspergillus
Aspergilloma	Aspergillus Nodule
Simple Aspergilloma	Aspergillus
Aspergillus Flavus Infection	Aspergillus Fumigatus Infection
Aspergillus Infection	Infection By Aspergillus Fumigatus
Intracavitary Aspergillus Fungus Ball	Aspergillus Terreus

Neurosyphilis

Syphilis Of Central Nervous System	Late Syphilis Of Central Nervous System Nos
Late Syphilis Of The Central Nervous System	Gumma Of Central Nervous System
Neurosyphilis Gumma	Neurosyphilitic Gumma
Syphilis Of Central Nervous System Nos	Syphilitic Gumma Of Central Nervous System
Tertiary Central Nervous System Syphilis

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Gastrointestinal Tularemia

Enteric Tularemia

Intestinal Tularaemia

Pelvic Inflammatory Disease

Pid

Lyme Disease

Lyme Borreliosis	Lyme Neuroborreliosis
Borreliosis	Borrelia Burgdorferi Infection
Neuroborreliosis	Bannwarth Syndrome
Bannworth'S Syndrome	Neurological Lyme Disease
B. Burgdorferi Infection	Borreliosis, Lyme
Infection By Borrelia Burgdorferi	Infection Due To Borrelia Burgdorferi Sensu Lato
Lym	Borrelia Infections

Leprosy 3

Leprosy	Leprosy, Susceptibility To, 3
Hansen'S Disease	Leprosy, Susceptibility To
Hansen Disease	Infection Due To Mycobacterium Leprae
LPRS3	Leprosy, Type 3
Anaesthesia Leprosy	Anaesthetic Leprosy
Maculoanaesthetic Leprosy	Macular Leprosy
Leprosy Unspecified

Invasive Aspergillosis

Aspergillosis Invasive

Endocarditis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P2036A	FSL-1 TFA	Agonist	99.65%	Unkown
HY-P2036	FSL-1	Agonist	/	Unkown
HY-P10586	Macrophage-activating lipopeptide 2	Activator	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TLR6	RGD	RGD:1303030
Macaca mulatta	TLR6	VGNC	VGNC:78395
Canis familiaris	TLR6	VGNC	VGNC:53249
Felis catus	TLR6	VGNC	VGNC:107475
Mus musculus	TLR6	MGD	MGI:1341296
Bos taurus	TLR6	VGNC	VGNC:50030

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