IRF9 - interferon regulatory factor 9 Gene

Homo sapiens

Also known as p48; IRF-9; ISGF3; ISGF3G

Gene ID: 10379 | Gene type: protein coding

About IRF9

Cytogenetic location: 14q12 Genomic coordinates (GRCh38): 14:24,161,265-24,166,565 (from NCBI)

This gene has 70 transcripts (splice variants), 1 gene allele, 277 orthologues, 8 paralogues and is associated with 1 phenotype. Ubiquitous expression in spleen (RPKM 55.3), appendix (RPKM 34.4) and 25 other tissues.

Summary

This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, Apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Mutations in this gene result in Immunodeficiency 65. [provided by RefSeq, Jul 2020]

IRF9 Products(4)

mRNA	Protein	Name
NM_001385400.1	NP_001372329.1	interferon regulatory factor 9 isoform 1
NM_001385401.1	NP_001372330.1	interferon regulatory factor 9 isoform 3
NM_001385402.1	NP_001372331.1	interferon regulatory factor 9 isoform 4
NM_006084.5	NP_006075.3	interferon regulatory factor 9 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IMP IMP: Inferred from mutant phenotype	24882218	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17923090	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	24065129	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of ISGF3 complex	IPI IPI: Inferred from physical interaction	24065129	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IRF9 Protein Structure

IRF

IRF-3

0
100
200
300
393 a.a.

Protein Preferred Names

Protein Names

interferon regulatory factor 9

IFN-alpha-responsive transcription factor subunit

Related Diseases

Diseases

Alias

Immunodeficiency 65 Viral Infections

Immunodeficiency 65, Susceptibility To Viral Infections	IMD65
Immunodeficiency 65

Immunodeficiency 65

Imd65

Immunodeficiency 65, Susceptibility To Viral Infections

Lymphocytic Choriomeningitis

Lcm	Lymphocytic Meningitis
Lymphocytic Choriomeningitis Virus Encephalomyelitis	Lymphocytic Meningoencephalitis
Non-Arthropod Borne Lymphocytic Choriomeningitis	Lcm - [Lymphocytic Choriomeningitis]
Benign Lymphocytic Meningitis	Meningitis Due To Lymphocytic Choriomeningitis Virus

Measles

Rubeola	Morbilli
Measles Nos	Koplik Spots

Herpes Simplex

Herpes Simplex Infections	Herpesvirus Hominis Disease
Herpes Simplex Disease	Herpesviral Infection Due To Herpes Simplex
Infections Due To Simplex Virus	Herpes Nos

Immunodeficiency 44

IMD44

Mumps

Parotitis Due To Mumps Virus	Mumps Nos
Epidemic Parotitis	Infectious Parotitis

Immunodeficiency 39

IMD39

Immunodeficiency, Type 39

Microphthalmia With Limb Anomalies

Waardenburg Anophthalmia Syndrome	Ophthalmoacromelic Syndrome
OAS	MLA
Anophthalmia-Syndactyly	Anophthalmia-Syndactyly Syndrome
Anophthalmos With Limb Anomalies	Anophthalmia Waardenburg Syndrome
Anophthalmos-Syndactyly	Ophthalmo-Acromelic Syndrome
Anophthalmia-Waardenburg Syndrome	Anophthalmos-Limb Anomalies Syndrome
Syndactyly-Anophthalmos Syndrome	Microphthalmia, With Limb Anomalies

Lymphopenia

Lymphocytopenia

Viral Infectious Disease

Viral Disease	Arbovirus Infections
Virus Infection	Virus Diseases
Viral Infection	Viral Infections
Virus Infections

Phlebotomus Fever

Pappataci Fever	Sandfly Fever
Sandfly-Borne Phleboviral Disease	Sandfly-Borne Arboviral Fever
Sandfly-Borne Bunyavirus Fever	Three Day Fever
Chitral Fever	Italy Summer Grippe
Italy Summer Grippe Influenza

Torch Syndrome

Herpangina

Vesicular Pharyngitis

West Nile Encephalitis

West-Nile Encephalitis	West Nile Fever
West Nile Fever Encephalitis	West Nile Fever With Encephalitis
West-Nile Fever	Encephalitis, West Nile Fever

Aicardi-Goutieres Syndrome

Aicardi Goutieres Syndrome	Cree Encephalitis
Aicardi-Goutières Syndrome	Encephalopathy With Basal Ganglia Calcification
Ags	Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid
Pseudotoxoplasmosis Syndrome	Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis
Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis	Aicardi-Goutieres Syndrome 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99666	Interferon alfa	Agonist	≥95.0%	Phase 4

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06913	IRF9 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	IRF9	MGD	MGI:107587
Rattus norvegicus	IRF9	RGD	RGD:1308766
Felis catus	IRF9	VGNC	VGNC:80948
Canis familiaris	IRF9	VGNC	VGNC:42097
Macaca mulatta	IRF9	VGNC	VGNC:84361
Bos taurus	IRF9	VGNC	VGNC:30280
Others	IRF9	NCBI

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