STAT2 - signal transducer and activator of transcription 2 Gene

Homo sapiens

Also known as P113; IMD44; ISGF-3; PTORCH3; STAT113

Gene ID: 6773 | Gene type: protein coding

About STAT2

Cytogenetic location: 12q13.3 Genomic coordinates (GRCh38): 12:56,341,597-56,360,107 (from NCBI)

This gene has 42 transcripts (splice variants), 197 orthologues, 6 paralogues and is associated with 5 phenotypes. Ubiquitous expression in spleen (RPKM 31.9), appendix (RPKM 25.0) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the STAT protein family. In response to Cytokines and Growth Factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. The protein mediates innate Antiviral activity. Mutations in this gene result in Immunodeficiency 44. [provided by RefSeq, Aug 2020]

STAT2 Products(7)

mRNA	Protein	Name
NM_001385110.1	NP_001372039.1	signal transducer and activator of transcription 2 isoform 3
NM_001385111.1	NP_001372040.1	signal transducer and activator of transcription 2 isoform 4
NM_001385113.1	NP_001372042.1	signal transducer and activator of transcription 2 isoform 5
NM_001385114.1	NP_001372043.1	signal transducer and activator of transcription 2 isoform 6
NM_001385115.1	NP_001372044.1	signal transducer and activator of transcription 2 isoform 7
NM_005419.4	NP_005410.1	signal transducer and activator of transcription 2 isoform 1
NM_198332.2	NP_938146.1	signal transducer and activator of transcription 2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	9020188	GOA
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	9020188	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	8605877	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8605876	GOA
enables ubiquitin-like protein ligase binding	IPI IPI: Inferred from physical interaction	27782195	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell surface receptor signaling pathway via JAK-STAT	IDA IDA: Inferred from direct assay	23139419	GOA
involved in defense response to virus	IMP IMP: Inferred from mutant phenotype	23391734	GOA
involved in negative regulation of type I interferon-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	28165510	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	24065129	GOA
involved in regulation of mitochondrial fission	IMP IMP: Inferred from mutant phenotype	26122121	GOA
involved in regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	26122121	GOA
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9020188	GOA
involved in type I interferon-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	23391734	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of ISGF3 complex	IPI IPI: Inferred from physical interaction	24065129	GOA
is active in nucleus	IDA IDA: Inferred from direct assay	23139419	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STAT2 Protein Structure

STAT_int

STAT_alpha

STAT_bind

SH2

STAT2_C

0
200
400
600
800
851 a.a.

Protein Preferred Names

Protein Names

signal transducer and activator of transcription 2

interferon alpha induced transcriptional activator

Related Diseases

Diseases

Alias

Pseudo-Torch Syndrome 3

PTORCH3

Immunodeficiency 44

IMD44

Primary Immunodeficiency With Post-Measles-Mumps-Rubella Vaccine Viral Infection

Primary Immunodeficiency With Post-Mmr Vaccine Viral Infection

Mumps

Parotitis Due To Mumps Virus	Mumps Nos
Epidemic Parotitis	Infectious Parotitis

Rabies

Lyssa	Hydrophobia
St Hubert Disease

Torch Syndrome

Dengue Virus

Dengue Virus, Susceptibility To	Dengue Fever, Protection Against
Dengue Fever

Measles

Rubeola	Morbilli
Measles Nos	Koplik Spots

Herpes Simplex

Herpes Simplex Infections	Herpesvirus Hominis Disease
Herpes Simplex Disease	Herpesviral Infection Due To Herpes Simplex
Infections Due To Simplex Virus	Herpes Nos

Thrombotic Microangiopathy

Tma

Vaccinia

Kunjin Encephalitis

Thrombocytopenia

Low Platelet Count	Low Platelets
Decreased Platelets	Platelet Dysfunction Nos

Immunodeficiency 28

IMD28	Ifngr2 Deficiency
Immunodeficiency 28, Mycobacteriosis, Autosomal Recessive	Immunodeficiency 28, Mycobacteriosis
Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Ifngammar2 Deficiency	Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Interferon Gamma Receptor 2 Deficiency
Msmd Due To Complete Ifngammar2 Deficiency	Msmd Due To Complete Interferon Gamma Receptor 2 Deficiency
Autosomal Recessive Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Ifngammar2 Deficiency	Autosomal Recessive Msmd Due To Partial Ifngammar2 Deficiency
Autosomal Recessive Msmd Due To Partial Interferon Gamma Receptor 2 Deficiency	Autosomal Recessive Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Interferon Gamma Receptor 2 Deficiency
Immunodeficiency, Type 28, Mycobacteriosis

Immunodeficiency 35

Tyrosine Kinase 2 Deficiency	IMD35
Tyk2 Deficiency	Autosomal Recessive Hyper-Ige Syndrome With Atypical Mycobacteriosis
Susceptibility To Infection Due To Tyk2 Deficiency	Hyper-Ige Syndrome With Atypical Mycobacteriosis, Autosomal Recessive
Hies With Atypical Mycobacteriosis, Autosomal Recessive	Autosomal Recessiv Hies With Atypical Mycobacteriosis
Autosomal Recessive Hyper-Ige Syndrome Due To Tyk2 Deficiency	Autosomal Recessive Hies With Atypical Mycobacteriosis

Viral Infectious Disease

Viral Disease	Arbovirus Infections
Virus Infection	Virus Diseases
Viral Infection	Viral Infections
Virus Infections

Microphthalmia With Limb Anomalies

Waardenburg Anophthalmia Syndrome	Ophthalmoacromelic Syndrome
OAS	MLA
Anophthalmia-Syndactyly	Anophthalmia-Syndactyly Syndrome
Anophthalmos With Limb Anomalies	Anophthalmia Waardenburg Syndrome
Anophthalmos-Syndactyly	Ophthalmo-Acromelic Syndrome
Anophthalmia-Waardenburg Syndrome	Anophthalmos-Limb Anomalies Syndrome
Syndactyly-Anophthalmos Syndrome	Microphthalmia, With Limb Anomalies

Dengue Shock Syndrome

Dss

Herpangina

Vesicular Pharyngitis

Dengue Hemorrhagic Fever

Severe Dengue	Dengue Haemorrhagic Fever
Dhf	Severe Dengue Haemorrhagic Fever
Severe Dengue Fever	Dengue Shock Syndrome

West Nile Encephalitis

West-Nile Encephalitis	West Nile Fever
West Nile Fever Encephalitis	West Nile Fever With Encephalitis
West-Nile Fever	Encephalitis, West Nile Fever

Zika Fever

Zika Virus Infection	Zika Virus Disease
Zika Virus	Zika Virus Fever
Mosquito-Borne Viral Fever, Zika

Japanese Encephalitis

Japanese B Encephalitis	Je
Encephalitis Japanese	Encephalitis, Japanese
Russian Autumnal Encephalitis	Je - [Japanese Encephalitis]
Japanese Encephalitis Virus Disease	Jbe - [Japanese B Encephalitis}
B Type Encephalitis

Aicardi-Goutieres Syndrome

Aicardi Goutieres Syndrome	Cree Encephalitis
Aicardi-Goutières Syndrome	Encephalopathy With Basal Ganglia Calcification
Ags	Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid
Pseudotoxoplasmosis Syndrome	Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis
Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis	Aicardi-Goutieres Syndrome 1

Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic	Acute Myeloblastic Leukemia Type 3
Aml M3	APL
Leukemia, Acute Promyelocytic, Somatic	Aml With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Apml
Acute Myeloblastic Leukemia 3	Acute Myeloid Leukemia With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Acute Myeloblastic Leukaemia Type 3
Acute Myeloid Leukaemia M3	Acute Myeloid Leukemia M3
Acute Promyelocytic Leukaemia	M3 Anll
Myeloid Leukemia, Acute, M3	Leukemia Promyelocytic Acute
Leukemia, Promyelocytic, Acute	Leukemia, Acute, Promyelocytic

Chronic Mucocutaneous Candidiasis

Candidiasis, Chronic Mucocutaneous	Cmc
Candidiasis Chronic Mucocutaneous

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

Fanconi Anemia, Complementation Group A

Fanconi Anemia	Fanconi Pancytopenia
Fanconi Anemia Complementation Group A	FANCA
Fa	Fanconi Panmyelopathy
Fanconi'S Anemia	Fanconi Anaemia
Fanconi'S Anaemia	Fanconi Hypoplastic Anemia
Estren-Dameshek Variant Of Fanconi Anemia	Estren-Dameshek Variant Of Fanconi Pancytopenia
Fanconi Anemia Estren-Dameshek Variant	Fanconis Anemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99666	Interferon alfa	Agonist	≥95.0%	Phase 4

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13887	STAT2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	STAT2	VGNC	VGNC:77905
Felis catus	STAT2	VGNC	VGNC:65760
Rattus norvegicus	STAT2	RGD	RGD:1311649
Bos taurus	STAT2	VGNC	VGNC:35370
Mus musculus	STAT2	MGD	MGI:103039
Canis familiaris	STAT2	VGNC	VGNC:108218
Others	STAT2	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.