2. Gene
  3. TESK2 - testis associated actin remodelling kinase 2 Gene

TESK2 - testis associated actin remodelling kinase 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 10420 | Gene type: protein coding

About TESK2

Cytogenetic location: 1p34.1 Genomic coordinates (GRCh38): 1:45,343,883-45,491,163 (from NCBI)

This gene has 4 transcripts (splice variants), 204 orthologues and 23 paralogues. Broad expression in prostate (RPKM 8.8), testis (RPKM 6.1) and 24 other tissues.

Summary

This gene product is a serine/threonine protein kinase that contains an N-terminal protein kinase domain that is structurally similar to the kinase domains of testis-specific protein kinase-1 and the LIM motif-containing protein kinases (LIMKs). Its overall structure is most related to the former, indicating that it belongs to the TESK subgroup of the LIMK/TESK family of protein kinases. This gene is predominantly expressed in testis and prostate. The developmental expression pattern of the rat gene in testis suggests an important role for this gene in meitoic stages and/or early stages of spermiogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

TESK2 Products(2)

mRNA Protein Name
NM_001320800.2 NP_001307729.1 dual specificity testis-specific protein kinase 2 isoform 2
NM_007170.3 NP_009101.2 dual specificity testis-specific protein kinase 2 isoform 1
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
22939624 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TESK2 Protein Structure

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (62 - 308)

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  • 571 a.a.
Protein Preferred Names Protein Names

dual specificity testis-specific protein kinase 2

testicular protein kinase 2

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14381 TESK2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris TESK2 VGNC VGNC:47257
Macaca mulatta TESK2 VGNC VGNC:78315
Bos taurus TESK2 VGNC VGNC:35755
Mus musculus TESK2 MGD MGI:2385204
Rattus norvegicus TESK2 RGD RGD:619984
Felis catus TESK2 VGNC VGNC:66090