CAP2 - cyclase associated actin cytoskeleton regulatory protein 2 Gene

Homo sapiens

Gene ID: 10486 | Gene type: protein coding

About CAP2

Cytogenetic location: 6p22.3 Genomic coordinates (GRCh38): 6:17,393,595-17,557,780 (from NCBI)

This gene has 7 transcripts (splice variants), 211 orthologues, 1 paralogue and is associated with 1 phenotype. Broad expression in brain (RPKM 40.2), heart (RPKM 39.1) and 15 other tissues.

Summary

This gene was identified by its similarity to the gene for human adenylyl cyclase-associated protein. The function of the protein encoded by this gene is unknown. However, the protein appears to be able to interact with adenylyl cyclase-associated protein and actin. [provided by RefSeq, Jul 2008]

CAP2 Products(3)

mRNA	Protein	Name
NM_001363533.2	NP_001350462.1	adenylyl cyclase-associated protein 2 isoform 3
NM_001363534.2	NP_001350463.1	adenylyl cyclase-associated protein 2 isoform 2
NM_006366.3	NP_006357.1	adenylyl cyclase-associated protein 2 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CAP2 Protein Structure

CAP_N

CAP_C

0
100
200
300
400
477 a.a.

Protein Preferred Names

Protein Names

adenylyl cyclase-associated protein 2

2810452G09Rik

CAP2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CAP2	P40123	CFL2	Homo sapiens	Q549N0	Y2H Array	25416956
Intra	CAP2	P40123	CFL2	Homo sapiens	Q549N0	Y2H Prey Pooling	25416956
Intra	CAP2	P40123	CFL2	Homo sapiens	Q549N0	Validated Y2H	25416956
Intra	CAP2	P40123	ACTG1	Homo sapiens	P63261	Validated Y2H	25416956
Intra	CAP2	P40123	ACTG1	Homo sapiens	P63261	Y2H Prey Pooling	32296183
Intra	CAP2	P40123	ACTG1	Homo sapiens	P63261	Validated Y2H	32296183
Intra	CAP2	P40123	CAP2	Homo sapiens	P40123	Y2H Prey Pooling	32296183
Intra	CAP2	P40123	ACTG1	Homo sapiens	P63261	Y2H Array	32296183
Intra	CAP2	P40123	CAP2	Homo sapiens	P40123	Y2H Array	25416956
Intra	CAP2	P40123	ACTB	Homo sapiens	P60709	Anti Tag CoIP	28514442
Intra	CAP2	P40123	ACTB	Homo sapiens	P60709	Anti Tag CoIP	33961781
Intra	CAP2	P40123	CAP2	Homo sapiens	P40123	Y2H Array	32296183
Intra	CAP2	P40123	ACTG1	Homo sapiens	P63261	Y2H Prey Pooling	25416956
Intra	CAP2	P40123	ADO	Homo sapiens	Q96SZ5	Validated Y2H	32296183
Intra	CAP2	P40123	ALAS1	Homo sapiens	P13196	Y2H Array	32296183
Intra	CAP2	P40123	ALAS1	Homo sapiens	P13196	Y2H Prey Pooling	32296183
Intra	CAP2	P40123	PS1TP5BP1	Homo sapiens	Q1KLZ0	Y2H Prey Pooling	25416956
Intra	CAP2	P40123	PS1TP5BP1	Homo sapiens	Q1KLZ0	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Familial Isolated Dilated Cardiomyopathy

Familial Or Idiopathic Dilated Cardiomyopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-149263	HAA-09	Inhibitor	/	Unkown
HY-E70081	mRNA Cap 2'-O-methyltransferase		/	Unkown
HY-RS01881	CAP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01900	CAPS2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-159855	CAP 2 hydrochloride		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CAP2	VGNC	VGNC:60347
Canis familiaris	CAP2	VGNC	VGNC:38696
Rattus norvegicus	CAP2	RGD	RGD:620310
Mus musculus	CAP2	MGD	MGI:1914502
Bos taurus	CAP2	VGNC	VGNC:26738
Macaca mulatta	CAP2	VGNC	VGNC:70584
Others	CAP2	NCBI

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