ADO - 2-aminoethanethiol dioxygenase Gene

Homo sapiens

Also known as C10orf22

Gene ID: 84890 | Gene type: protein coding

About ADO

Cytogenetic location: 10q21.3 Genomic coordinates (GRCh38): 10:62,804,720-62,808,479 (from NCBI)

This gene has 1 transcript (splice variant) and 247 orthologues.

Summary

Human thiol dioxygenases include cysteine dioxygenase (CDO; MIM 603943) and cysteamine (2-aminoethanethiol) dioxygenase (ADO; EC 1.13.11.19). CDO adds 2 oxygen atoms to free cysteine, whereas ADO adds 2 oxygen atoms to free cysteamine to form hypotaurine (Dominy et al., 2007 [PubMed 17581819]).[supplied by OMIM, Mar 2008]

ADO Products(1)

mRNA	Protein	Name
NM_032804.6	NP_116193.2	2-aminoethanethiol dioxygenase

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables cysteamine dioxygenase activity	IDA IDA: Inferred from direct assay	31273118	GOA
enables cysteamine dioxygenase activity	IMP IMP: Inferred from mutant phenotype	17581819	GOA
enables iron ion binding	IDA IDA: Inferred from direct assay	34508780	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to hypoxia	IDA IDA: Inferred from direct assay	31273118	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ADO Protein Structure

PCO_ADO

0
100
200
270 a.a.

Protein Preferred Names

Protein Names

2-aminoethanethiol dioxygenase

2-aminoethanethiol (cysteamine) dioxygenase

ADO Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ADO	Q96SZ5	CAP2	Homo sapiens	P40123	Y2H Prey Pooling	32296183
Intra	ADO	Q96SZ5	CAP2	Homo sapiens	P40123	Y2H Array	32296183
Intra	ADO	Q96SZ5	DISC1	Homo sapiens	Q9NRI5-2	Validated Y2H	32296183
Intra	ADO	Q96SZ5	DISC1	Homo sapiens	Q9NRI5-2	Y2H Array	32296183
Intra	ADO	Q96SZ5	DISC1	Homo sapiens	Q9NRI5-2	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Ataxia, Sensory, 1, Autosomal Dominant

Autosomal Dominant Sensory Ataxia 1	SNAX1
Adsa	Ataxia, Sensory, Type 1, Autosomal Dominant
Ataxia, Sensory, Autosomal Dominant

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P9921	Trastuzumab emtansine	Inhibitor	99.74%	Unkown
HY-P9921A	Trastuzumab emtansine (solution)		/	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-19842	GS-9667	Agonist	98.08%	Phase 1

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-103400	8-Chloroadenosine		99.97%	Unkown
HY-148327	AK-IN-1	Inhibitor	99.95%	Unkown
HY-125927	8-Aminoadenosine		99.94%	Unkown
HY-134313	8-NH2-ATP		/	Unkown
HY-134313A	8-NH2-ATP tetrasodium		≥98.0%	Unkown
HY-RS00390	ADO Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-123038	CVT-5440	Antagonist	/	Unkown
HY-123196	CVT-2759	Inhibitor	/	Unkown
HY-15903	ADOS		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ADO	VGNC	VGNC:69675
Rattus norvegicus	ADO	RGD	RGD:1308233
Canis familiaris	ADO	VGNC	VGNC:37664
Bos taurus	ADO	VGNC	VGNC:25685
Mus musculus	ADO	MGD	MGI:2685083
Felis catus	ADO	VGNC	VGNC:59647
Others	ADO	NCBI

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