DDX17 - DEAD-box helicase 17 Gene

Homo sapiens

Also known as P72; RH70

Gene ID: 10521 | Gene type: protein coding

About DDX17

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:38,483,438-38,506,311 (from NCBI)

This gene has 10 transcripts (splice variants), 167 orthologues and 38 paralogues. Ubiquitous expression in spleen (RPKM 144.6), endometrium (RPKM 136.4) and 25 other tissues.

Summary

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and splicesosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an ATPase activated by a variety of RNA species, but not by dsDNA. This protein, and that encoded by DDX5 gene, are more closely related to each Other than to any Other member of the DEAD box family. This gene can encode multiple isoforms due to both alternative splicing and the use of alternative translation initiation codons, including a non-AUG (CUG) start codon. [provided by RefSeq, Apr 2011]

DDX17 Products(2)

mRNA	Protein	Name
NM_001098504.2	NP_001091974.1	probable ATP-dependent RNA helicase DDX17 isoform 3
NM_006386.5	NP_006377.2	probable ATP-dependent RNA helicase DDX17 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14559993	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	17226766	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in alternative mRNA splicing, via spliceosome	IMP IMP: Inferred from mutant phenotype	24275493	GOA
involved in androgen receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	24275493	GOA
involved in epithelial to mesenchymal transition	IMP IMP: Inferred from mutant phenotype	24910439	GOA
involved in estrogen receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	24275493	GOA
involved in miRNA metabolic process	IMP IMP: Inferred from mutant phenotype	27478153	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17226766	GOA
involved in regulation of alternative mRNA splicing, via spliceosome	IMP IMP: Inferred from mutant phenotype	23022728	GOA
involved in regulation of skeletal muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	17011493	GOA
involved in regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	24275493	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	24910439	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DDX17 Protein Structure

DEAD

Helicase_C

0
200
400
600
729 a.a.

Protein Preferred Names

Protein Names

probable ATP-dependent RNA helicase DDX17

DEAD (Asp-Glu-Ala-Asp) box helicase 17

DDX17 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	DDX17	Q92841	YAP1	Homo sapiens	P46937	Anti Bait CoIP	24581491
Intra	DDX17	Q92841	YAP1	Homo sapiens	P46937	GMS	24581491
Intra	DDX17	Q92841	YAP1	Homo sapiens	P46937	Anti Tag CoIP	24581491
Intra	DDX17	Q92841	RBM15	Homo sapiens	Q96T37	Validated Y2H	25416956
Intra	DDX17	Q92841	NFAT5	Homo sapiens	O94916	Anti Tag CoIP	22266867
Intra	DDX17	Q92841	DDX5	Homo sapiens	P17844	Anti Tag CoIP	33961781
Intra	DDX17	Q92841	DDX5	Homo sapiens	P17844	Anti Tag CoIP	24581491
Intra	DDX17	Q92841	BYSL	Homo sapiens	Q13895	Validated Y2H	25416956
Intra	DDX17	Q92841	BYSL	Homo sapiens	Q13895	Y2H Prey Pooling	25416956
Intra	DDX17	Q92841	TP53	Homo sapiens	P04637	Anti Bait CoIP	15660129
Intra	DDX17	Q92841	EXOSC3	Homo sapiens	Q9NQT5	Anti Bait CoIP	18334637
Intra	DDX17	Q92841	GRB2	Homo sapiens	P62993	Y2H Array	25416956
Intra	DDX17	Q92841	GRB2	Homo sapiens	P62993	Y2H Prey Pooling	25416956
Intra	DDX17	Q92841	LNX1	Homo sapiens	Q8TBB1	Y2H Array	32296183
Intra	DDX17	Q92841	LNX1	Homo sapiens	Q8TBB1	Y2H Pooling	16189514
Intra	DDX17	Q92841	SF1	Homo sapiens	Q15637	Y2H Fragment Pooling	26420826

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Rift Valley Fever

Rfv - [Rift Valley Fever]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03632	DDX17 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	DDX17	VGNC	VGNC:71762
Felis catus	DDX17	VGNC	VGNC:61398
Bos taurus	DDX17	VGNC	VGNC:27957
Mus musculus	DDX17	MGD	MGI:1914290
Canis familiaris	DDX17	VGNC	VGNC:39846
Rattus norvegicus	DDX17	RGD	RGD:1304945

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