2. Gene
  3. RBM15 - RNA binding motif protein 15 Gene

RBM15 - RNA binding motif protein 15 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as OTT; OTT1; SPEN

Gene ID: 64783 | Gene type: protein coding

About RBM15

Cytogenetic location: 1p13.3 Genomic coordinates (GRCh38): 1:110,339,377-110,346,677 (from NCBI)

This gene has 9 transcripts (splice variants), 259 orthologues, 7 paralogues and is associated with 58 phenotypes. Broad expression in bone marrow (RPKM 6.3), testis (RPKM 2.8) and 24 other tissues.

Summary

Members of the SPEN (Split-end) family of proteins, including RBM15, have repressor function in several signaling pathways and may bind to RNA through interaction with spliceosome components (Hiriart et al., 2005 [PubMed 16129689]).[supplied by OMIM, Feb 2009]

RBM15 Products(2)

mRNA Protein Name
NM_001201545.2 NP_001188474.1 RNA-binding protein 15 isoform 2
NM_022768.5 NP_073605.4 RNA-binding protein 15 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables RNA binding IDA
IDA: Inferred from direct assay
27602518 GOA
enables mRNA binding IDA
IDA: Inferred from direct assay
26575292 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16129689 GOA
Biological Process GO Annotation Evidence Reference Source
involved in RNA methylation IDA
IDA: Inferred from direct assay
27602518 GOA
involved in dosage compensation by inactivation of X chromosome IDA
IDA: Inferred from direct assay
27602518 GOA
NOT involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
16129689 GOA
involved in regulation of alternative mRNA splicing, via spliceosome IDA
IDA: Inferred from direct assay
26575292 GOA
involved in regulation of megakaryocyte differentiation IDA
IDA: Inferred from direct assay
26575292 GOA
Cellular Component GO Annotation Evidence Reference Source
part of RNA N6-methyladenosine methyltransferase complex IDA
IDA: Inferred from direct assay
27602518 GOA
located in nuclear speck IDA
IDA: Inferred from direct assay
24100041 GOA
located in nucleoplasm IDA
IDA: Inferred from direct assay
24100041 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RBM15 Protein Structure

RRM_5

RRM_5: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (190 - 248)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (376 - 444)

RRM_5

RRM_5: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (471 - 527)

SPOC

SPOC: SPOC domain (788 - 924)

  • 0
  • 200
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  • 600
  • 800
  • 977 a.a.
Protein Preferred Names Protein Names

RNA-binding protein 15

one twenty two protein

RBM15 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra RBM15 Q96T37 CALCOCO2 Homo sapiens Q13137
Validated Y2H
25416956
Intra RBM15 Q96T37 LZTS2 Homo sapiens Q9BRK4
Y2H Prey Pooling
25416956
Intra RBM15 Q96T37 LZTS2 Homo sapiens Q9BRK4
Validated Y2H
25416956
Intra RBM15 Q96T37 NAV2 Homo sapiens Q8IVL1
Validated Y2H
25416956
Intra RBM15 Q96T37 NAV2 Homo sapiens Q8IVL1
Y2H Prey Pooling
25416956
Intra RBM15 Q96T37 CEP44 Homo sapiens Q9C0F1
Validated Y2H
25416956
Intra RBM15 Q96T37 CEP44 Homo sapiens Q9C0F1
Y2H Prey Pooling
25416956
Intra RBM15 Q96T37 CEP44 Homo sapiens Q9C0F1
Y2H Array
25416956
Intra RBM15 Q96T37 DDX17 Homo sapiens Q92841
Y2H Array
25416956
Intra RBM15 Q96T37 DDX17 Homo sapiens Q92841
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Megakaryoblastic Acute Myeloid Leukemia With T(1;22)(P13;Q13)

Megakaryoblastic Aml With T(1

22)(P13

Q13)
Acute Megakaryocytic Leukemia

Acute Megakaryoblastic Leukemia

Acute Megakaryoblastic Leukaemia

Megakaryocytic Myelosis

Thrombocytic Leukaemia

Amkl

Aml M7

Acute Myeloblastic Leukemia Type 7

Acute Myeloid Leukemia M7

Megakaryoblastic Leukemia Acute

Leukemia, Megakaryoblastic, Acute

Acute Myeloid Leukaemia, M7

Acute Megakaryocytic Leukaemia

Acute Megakaryoblastic Leukaemia, Fab M7

Fab M7

Malignant Megakaryocytosis

M7 - Acute Megakaryoblastic Leukaemia

Megakaryoblastic Leukaemia

Megakaryocytic Leukaemia

Acute Megakaryoblastic Leukaemia, Nos

Acute Megakaryoblastic Leukaemia Without Mention Of Remission
Neonatal Leukemia
Myeloproliferative Syndrome, Transient

Transient Abnormal Myelopoiesis

Transient Myeloproliferative Syndrome

Transient Myeloproliferative Disease

Mst

Tam

Leukemia, Transient, Of Down Syndrome

Tmd

Leukemia, Transient

Transient Leukemia

Transient Leukemia Of Down Syndrome
Chromosome 1p36 Deletion Syndrome

1p36 Deletion Syndrome

Deletion 1p36

Monosomy 1p36

Subtelomeric 1p36 Deletion

Monosomy 1p36 Syndrome

Distal Monosomy 1p36

Del(1)(P36)

Deletion 1pter

Monosomy 1pter
Wilms Tumor 1

Nephroblastoma

Wilms Tumor

WT1

Wilms' Tumor

Bilateral Wilms Tumor

Wilms Tumor, Type 1

Wilms Tumor, Somatic

Adult Nephroblastoma

Wt1 Disorder

Renal Embryonic Tumor

Adult Kidney Wilms Tumor

Childhood Kidney Wilms Tumor

Nonanaplastic Kidney Wilms Tumor
Leukemia, Acute Myeloid

Acute Myeloid Leukemia

Leukemia, Acute Myelogenous

Acute Myelogenous Leukemia

AML

Leukemia, Acute Myeloid, Susceptibility To

Acute Myeloblastic Leukemia

Leukemia, Acute Myeloid, Reduced Survival In, Somatic

Acute Myeloid Leukaemia

Leukemia, Myelocytic, Acute

Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

Secondary Aml

Acute Myelocytic Leukemia

Acute Myeloid Leukemia, Somatic

Leukemia, Acute Myeloid, Somatic

Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

Acute Myeloblastic Leukaemia

Acute Myelogenous Leukaemia

Aml - Acute Myeloid Leukemia

Acute Myeloid Leukemia With Cebpa Somatic Mutations

Aml With Cebpa Somatic Mutations

Inherited Acute Myeloid Leukemia

Familial Aml

Inherited Aml

Pure Familial Aml

Pure Familial Acute Myeloid Leukemia

Secondary Acute Myeloid Leukemia

Therapy-Related Aml And Myelodysplastic Syndrome

Acute Myeloid Leukemia, Secondary

Acute Non-Lymphoblastic Leukemia

Acute Non-Lymphocytic Leukemia

Acute Biphenotypic Leukemia

Acute Undifferentiated Leukemia

Acute Myeloblastic Leukaemia With Multilineage Dysplasia

Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11735 RBM15 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS11736 RBM15B Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus RBM15 RGD RGD:1592713
Felis catus RBM15 VGNC VGNC:64521
Macaca mulatta RBM15 VGNC VGNC:76481
Mus musculus RBM15 MGD MGI:2443205
Canis familiaris RBM15 VGNC VGNC:45409
Bos taurus RBM15 VGNC VGNC:33787