CCT4 - chaperonin containing TCP1 subunit 4 Gene

Homo sapiens

Also known as SRB; Cctd; CCT-DELTA

Gene ID: 10575 | Gene type: protein coding

About CCT4

Cytogenetic location: 2p15 Genomic coordinates (GRCh38): 2:61,868,085-61,888,671 (from NCBI)

This gene has 4 transcripts (splice variants), 227 orthologues and 13 paralogues. Ubiquitous expression in ovary (RPKM 58.5), testis (RPKM 51.7) and 25 other tissues.

Summary

The chaperonin containing TCP1 (MIM 186980) complex (CCT), also called the TCP1 ring complex, consists of 2 back-to-back rings, each containing 8 unique but homologous subunits, such as CCT4. CCT assists the folding of newly translated polypeptide substrates through multiple rounds of ATP-driven release and rebinding of partially folded intermediate forms. Substrates of CCT include the cytoskeletal proteins actin (see MIM 102560) and tubulin (see MIM 191130), as well as alpha-transducin (MIM 139330) (Won et al., 1998 [PubMed 9819444]).[supplied by OMIM, Mar 2008]

CCT4 Products(2)

mRNA	Protein	Name
NM_001256721.1	NP_001243650.1	T-complex protein 1 subunit delta isoform b
NM_006430.4	NP_006421.2	T-complex protein 1 subunit delta isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16085932	GOA
enables protein folding chaperone	IDA IDA: Inferred from direct assay	25467444	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in chaperone mediated protein folding independent of cofactor	IMP IMP: Inferred from mutant phenotype	25467444	GOA
involved in chaperone-mediated protein folding	IDA IDA: Inferred from direct assay	22133715	GOA
involved in positive regulation of telomerase RNA localization to Cajal body	IMP IMP: Inferred from mutant phenotype	25467444	GOA
acts upstream of positive regulation of telomere maintenance via telomerase	IMP IMP: Inferred from mutant phenotype	25467444	GOA
involved in protein folding	IDA IDA: Inferred from direct assay	30955883	GOA
involved in protein stabilization	IMP IMP: Inferred from mutant phenotype	25467444	GOA
acts upstream of positive effect scaRNA localization to Cajal body	IMP IMP: Inferred from mutant phenotype	25467444	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in centrosome	IDA IDA: Inferred from direct assay	20080638	GOA
part of chaperonin-containing T-complex	IDA IDA: Inferred from direct assay	23011926	GOA
part of chaperonin-containing T-complex	IPI IPI: Inferred from physical interaction	22133715	GOA
located in microtubule	IDA IDA: Inferred from direct assay	21525035	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CCT4 Protein Structure

Cpn60_TCP1

0
100
200
300
400
500
539 a.a.

Protein Preferred Names

Protein Names

T-complex protein 1 subunit delta

TCP-1-delta

CCT4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CCT4	P50991	TCP1	Homo sapiens	P17987	Anti Tag CoIP	35271311
Intra	CCT4	P50991	CCT2	Homo sapiens	P78371	Anti Tag CoIP	35271311
Intra	CCT4	P50991	CCT2	Homo sapiens	P78371	Validated Y2H	32296183
Intra	CCT4	P50991	OLR1	Homo sapiens	P78380	Pull Down	24846140
Intra	CCT4	P50991	CCNH	Homo sapiens	P51946	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Sensory Peripheral Neuropathy

Sensory Neuropathy	Peripheral Sensory Neuropathy
Hereditary Sensory And Autonomic Neuropathies

Posterior Cerebral Artery Infarction

Infarction, Posterior Cerebral Artery

Peroxisome Biogenesis Disorder 11a

PBD11A	Peroxisome Biogenesis Disorder Complementation Group 13
PBD-CG13	Cg13
Pbd-Cgh	Peroxisome Biogenesis Disorder Complementation Group H
Peroxisome Biogenesis Disorder, Type 11a	Peroxisome Biogenesis Disorder, Complementation Group 13

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02181	CCT4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CCT4	VGNC	VGNC:26997
Felis catus	CCT4	VGNC	VGNC:60578
Canis familiaris	CCT4	VGNC	VGNC:38924
Mus musculus	CCT4	MGD	MGI:104689
Macaca mulatta	CCT4	VGNC	VGNC:70747
Rattus norvegicus	CCT4	RGD	RGD:727937

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