2. Gene
  3. TRIM3 - tripartite motif containing 3 Gene

TRIM3 - tripartite motif containing 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as BERP; HAC1; RNF22; RNF97

Gene ID: 10612 | Gene type: protein coding

About TRIM3

Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38): 11:6,448,613-6,474,459 (from NCBI)

This gene has 14 transcripts (splice variants), 266 orthologues and 80 paralogues. Ubiquitous expression in duodenum (RPKM 6.6), small intestine (RPKM 6.1) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also called the 'RING-B-box-coiled-coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to cytoplasmic filaments. It is similar to a rat protein which is a specific partner for the tail domain of Myosin V, a class of myosins which are involved in the targeted transport of organelles. The rat protein can also interact with alpha-actinin-4. Thus it is suggested that this human protein may play a role in Myosin V-mediated cargo transport. Alternatively spliced transcript variants encoding the same isoform have been identified. [provided by RefSeq, Jul 2008]

TRIM3 Products(4)

mRNA Protein Name
NM_001248006.2 NP_001234935.1 tripartite motif-containing protein 3 isoform 1
NM_001248007.2 NP_001234936.1 tripartite motif-containing protein 3 isoform 2
NM_006458.4 NP_006449.2 tripartite motif-containing protein 3 isoform 1
NM_033278.4 NP_150594.2 tripartite motif-containing protein 3 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19460345 GOA
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
32878999 GOA
Biological Process GO Annotation Evidence Reference Source
involved in neural precursor cell proliferation IMP
IMP: Inferred from mutant phenotype
38225354 GOA
involved in positive regulation of toll-like receptor 3 signaling pathway IDA
IDA: Inferred from direct assay
32878999 GOA
involved in protein K63-linked ubiquitination IDA
IDA: Inferred from direct assay
32878999 GOA
Cellular Component GO Annotation Evidence Reference Source
is active in Golgi apparatus IDA
IDA: Inferred from direct assay
32878999 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRIM3 Protein Structure

zf-C3HC4

zf-C3HC4: Zinc finger, C3HC4 type (RING finger) (22 - 62)

zf-B_box

zf-B_box: B-box zinc finger (113 - 150)

Filamin

Filamin: Filamin/ABP280 repeat (321 - 415)

NHL

NHL: NHL repeat (486 - 513)

NHL

NHL: NHL repeat (533 - 560)

NHL

NHL: NHL repeat (577 - 602)

NHL

NHL: NHL repeat (622 - 649)

NHL

NHL: NHL repeat (669 - 696)

NHL

NHL: NHL repeat (713 - 737)

  • 0
  • 200
  • 400
  • 600
  • 744 a.a.
Protein Preferred Names Protein Names

tripartite motif-containing protein 3

RING finger protein 97

TRIM3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
TRIM3 O75382 UBE2I Homo sapiens Q7KZS0
Y2H Array
32296183
Intra
TRIM3 O75382 UBE2I Homo sapiens Q7KZS0
Y2H Prey Pooling
32296183
Intra
TRIM3 O75382 UBE2I Homo sapiens Q7KZS0
Validated Y2H
32296183
Intra
TRIM3 O75382 KCTD7 Homo sapiens Q96MP8-2
Y2H Prey Pooling
32296183
Intra
TRIM3 O75382 KCTD7 Homo sapiens Q96MP8-2
Validated Y2H
32296183
Intra
TRIM3 O75382 KCTD7 Homo sapiens Q96MP8-2
Y2H Array
32296183
Intra
TRIM3 O75382 TEAD1 Homo sapiens P28347-2
Validated Y2H
32296183
Intra
TRIM3 O75382 USP32 Homo sapiens Q8NFA0-2
Validated Y2H
32296183
Intra
TRIM3 O75382 ROPN1 Homo sapiens Q9HAT0
Validated Y2H
32296183
Intra
TRIM3 O75382 MYO5B Homo sapiens Q9ULV0-2
Validated Y2H
32296183
Intra
TRIM3 O75382 UBE2E2 Homo sapiens Q96LR5
Validated Y2H
32296183
Intra
TRIM3 O75382 TRIM2 Homo sapiens Q9C040
Validated Y2H
32296183
Intra
TRIM3 O75382 UBE2Z Homo sapiens Q9H832
Validated Y2H
32296183
Intra
TRIM3 O75382 CEP70 Homo sapiens Q8NHQ1
Y2H Prey Pooling
32296183
Intra
TRIM3 O75382 CEP70 Homo sapiens Q8NHQ1
Y2H Array
32296183
Intra
TRIM3 O75382 CEP70 Homo sapiens Q8NHQ1
Validated Y2H
32296183
Intra
TRIM3 O75382 LNX1 Homo sapiens Q8TBB1
Validated Y2H
32296183
Intra
TRIM3 O75382 UBE2D1 Homo sapiens P51668
Validated Y2H
32296183
Intra
TRIM3 O75382 CSNK1E Homo sapiens P49674
Validated Y2H
32296183
Intra
TRIM3 O75382 ASL Homo sapiens P04424
Validated Y2H
32296183
Intra
TRIM3 O75382 ASL Homo sapiens P04424
Y2H Array
32296183
Intra
TRIM3 O75382 ASL Homo sapiens P04424
Y2H Prey Pooling
32296183
Intra
TRIM3 O75382 CSNK1D Homo sapiens P48730
Validated Y2H
32296183
Intra
TRIM3 O75382 TRIM21 Homo sapiens P19474
Validated Y2H
32296183
Intra
TRIM3 O75382 TRIM21 Homo sapiens P19474
Y2H Array
32296183
Intra
TRIM3 O75382 TRIM21 Homo sapiens P19474
Y2H Prey Pooling
32296183
Intra
TRIM3 O75382 LRRC8E Homo sapiens Q6NSJ5
Validated Y2H
32296183
Intra
TRIM3 O75382 TEAD2 Homo sapiens Q15562-2
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15035 TRIM3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus TRIM3 VGNC VGNC:66533
Macaca mulatta TRIM3 VGNC VGNC:78549
Rattus norvegicus TRIM3 RGD RGD:70074
Mus musculus TRIM3 MGD MGI:1860040
Canis familiaris TRIM3 VGNC VGNC:47813
Bos taurus TRIM3 VGNC VGNC:36326
Others TRIM3 NCBI