2. Gene
  3. TRIM3 - tripartite motif containing 3 Gene

TRIM3 - tripartite motif containing 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as BERP; HAC1; RNF22; RNF97

Gene ID: 10612 | Gene type: protein coding

About TRIM3

Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38): 11:6,448,613-6,474,459 (from NCBI)

This gene has 14 transcripts (splice variants), 266 orthologues and 80 paralogues. Ubiquitous expression in duodenum (RPKM 6.6), small intestine (RPKM 6.1) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also called the 'RING-B-box-coiled-coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to cytoplasmic filaments. It is similar to a rat protein which is a specific partner for the tail domain of Myosin V, a class of myosins which are involved in the targeted transport of organelles. The rat protein can also interact with alpha-actinin-4. Thus it is suggested that this human protein may play a role in Myosin V-mediated cargo transport. Alternatively spliced transcript variants encoding the same isoform have been identified. [provided by RefSeq, Jul 2008]

TRIM3 Products(4)

mRNA Protein Name
NM_001248006.2 NP_001234935.1 tripartite motif-containing protein 3 isoform 1
NM_001248007.2 NP_001234936.1 tripartite motif-containing protein 3 isoform 2
NM_006458.4 NP_006449.2 tripartite motif-containing protein 3 isoform 1
NM_033278.4 NP_150594.2 tripartite motif-containing protein 3 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19460345 GOA
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
32878999 GOA
Biological Process GO Annotation Evidence Reference Source
involved in neural precursor cell proliferation IMP
IMP: Inferred from mutant phenotype
38225354 GOA
involved in positive regulation of toll-like receptor 3 signaling pathway IDA
IDA: Inferred from direct assay
32878999 GOA
involved in protein K63-linked ubiquitination IDA
IDA: Inferred from direct assay
32878999 GOA
Cellular Component GO Annotation Evidence Reference Source
is active in Golgi apparatus IDA
IDA: Inferred from direct assay
32878999 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRIM3 Protein Structure

zf-C3HC4

zf-C3HC4: Zinc finger, C3HC4 type (RING finger) (22 - 62)

zf-B_box

zf-B_box: B-box zinc finger (113 - 150)

Filamin

Filamin: Filamin/ABP280 repeat (321 - 415)

NHL

NHL: NHL repeat (486 - 513)

NHL

NHL: NHL repeat (533 - 560)

NHL

NHL: NHL repeat (577 - 602)

NHL

NHL: NHL repeat (622 - 649)

NHL

NHL: NHL repeat (669 - 696)

NHL

NHL: NHL repeat (713 - 737)

  • 0
  • 200
  • 400
  • 600
  • 744 a.a.
Protein Preferred Names Protein Names

tripartite motif-containing protein 3

RING finger protein 97

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15035 TRIM3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus TRIM3 VGNC VGNC:66533
Macaca mulatta TRIM3 VGNC VGNC:78549
Rattus norvegicus TRIM3 RGD RGD:70074
Mus musculus TRIM3 MGD MGI:1860040
Canis familiaris TRIM3 VGNC VGNC:47813
Bos taurus TRIM3 VGNC VGNC:36326
Others TRIM3 NCBI