UBE2Z - ubiquitin conjugating enzyme E2 Z Gene

Homo sapiens

Also known as USE1; HOYS7

Gene ID: 65264 | Gene type: protein coding

About UBE2Z

Cytogenetic location: 17q21.32 Genomic coordinates (GRCh38): 17:48,908,407-48,929,056 (from NCBI)

This gene has 8 transcripts (splice variants), 206 orthologues and 24 paralogues. Ubiquitous expression in thyroid (RPKM 33.3), brain (RPKM 25.6) and 25 other tissues.

Summary

This gene encodes an Enzyme which ubiquitinates proteins which participate in signaling pathways and Apoptosis. [provided by RefSeq, Feb 2012]

UBE2Z Products(1)

mRNA	Protein	Name
NM_023079.5	NP_075567.2	ubiquitin-conjugating enzyme E2 Z

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables molecular adaptor activity	EXP EXP: Inferred from Experiment	26555268	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	17464193	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	17464193	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UBE2Z Protein Structure

UQ_con

0
100
200
300
354 a.a.

Protein Preferred Names

Protein Names

ubiquitin-conjugating enzyme E2 Z

E2 ubiquitin-conjugating enzyme Z

UBE2Z Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	UBE2Z	Q9H832	PLEKHA6	Homo sapiens	Q9Y2H5	Validated Y2H	32296183
Intra	UBE2Z	Q9H832	PLEKHA6	Homo sapiens	Q9Y2H5	Y2H Array	32296183
Intra	UBE2Z	Q9H832	PLEKHA6	Homo sapiens	Q9Y2H5	Y2H Prey Pooling	32296183
Intra	UBE2Z	Q9H832	TRIM3	Homo sapiens	O75382	Y2H Prey Pooling	32296183
Intra	UBE2Z	Q9H832	TRIM3	Homo sapiens	O75382	Y2H Array	32296183
Intra	UBE2Z	Q9H832	HMBOX1	Homo sapiens	Q6NT76	Y2H Prey Pooling	25416956
Intra	UBE2Z	Q9H832	REL	Homo sapiens	Q04864	Y2H Array	25416956
Intra	UBE2Z	Q9H832	REL	Homo sapiens	Q04864	Y2H Prey Pooling	25416956
Intra	UBE2Z	Q9H832	CCT3	Homo sapiens	P49368	Y2H Prey Pooling	32296183
Intra	UBE2Z	Q9H832	CCT3	Homo sapiens	P49368	Y2H Array	32296183
Intra	UBE2Z	Q9H832	INCA1	Homo sapiens	Q0VD86	Y2H Prey Pooling	32296183
Intra	UBE2Z	Q9H832	INCA1	Homo sapiens	Q0VD86	Y2H Array	32296183
Intra	UBE2Z	Q9H832	GORASP2	Homo sapiens	Q9H8Y8	Validated Y2H	32296183
Intra	UBE2Z	Q9H832	GORASP2	Homo sapiens	Q9H8Y8	Y2H Array	32296183
Intra	UBE2Z	Q9H832	GORASP2	Homo sapiens	Q9H8Y8	Y2H Prey Pooling	32296183
Intra	UBE2Z	Q9H832	PLEKHF2	Homo sapiens	Q9H8W4	Validated Y2H	32296183
Intra	UBE2Z	Q9H832	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Prey Pooling	32296183
Intra	UBE2Z	Q9H832	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Pooling	16189514
Intra	UBE2Z	Q9H832	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Array	32296183
Intra	UBE2Z	Q9H832	AK8	Homo sapiens	Q96MA6	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant UBE2Z Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71412	UBE2Z Protein, Human (His)	Q9H832-2 (M1-V246)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15367	UBE2Z Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	UBE2Z	VGNC	VGNC:104671
Canis familiaris	UBE2Z	VGNC	VGNC:48067
Felis catus	UBE2Z	VGNC	VGNC:99568
Rattus norvegicus	UBE2Z	RGD	RGD:1308347
Bos taurus	UBE2Z	VGNC	VGNC:36598
Mus musculus	UBE2Z	MGD	MGI:1343160
Others	UBE2Z	NCBI

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