1. Gene
  2. CSNK1D - casein kinase 1 delta Gene

CSNK1D - casein kinase 1 delta Gene

Homo sapiens

Also known as ASPS; CKId; HCKID; FASPS2; CKIdelta; CKI-delta

Gene ID: 1453 | Gene type: protein coding

About CSNK1D

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:82,239,019-82,273,750 (from NCBI)

This gene has 26 transcripts (splice variants), 264 orthologues, 12 paralogues and is associated with 2 phenotypes. Ubiquitous expression in spleen (RPKM 17.2), prostate (RPKM 17.2) and 25 other tissues.

Summary

This gene is a member of the Casein Kinase I (CKI) gene family whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein may also be involved in the regulation of Apoptosis, circadian rhythm, microtubule dynamics, chromosome segregation, and p53-mediated effects on growth. The encoded protein is highly similar to the mouse and rat CK1 delta homologs. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]

CSNK1D Products(3)

mRNA Protein Name
NM_001363749.2 NP_001350678.1 casein kinase I isoform delta isoform 3
NM_001893.6 NP_001884.2 casein kinase I isoform delta isoform 1
NM_139062.4 NP_620693.1 casein kinase I isoform delta isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
enables protein kinase activity IDA
IDA: Inferred from direct assay
16618118 GOA
enables protein kinase activity IMP
IMP: Inferred from mutant phenotype
19591487 GOA
enables protein serine kinase activity IDA
IDA: Inferred from direct assay
12270943 GOA
enables protein serine kinase activity IMP
IMP: Inferred from mutant phenotype
19043076 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
10606744 GOA
enables tau-protein kinase activity IDA
IDA: Inferred from direct assay
16618118 GOA
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within Golgi organization IMP
IMP: Inferred from mutant phenotype
24648492 GOA
acts upstream of or within microtubule nucleation IMP
IMP: Inferred from mutant phenotype
24648492 GOA
acts upstream of or within non-motile cilium assembly IMP
IMP: Inferred from mutant phenotype
24648492 GOA
involved in positive regulation of canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
20412773 GOA
involved in positive regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
20412773 GOA
acts upstream of or within protein localization to Golgi apparatus IMP
IMP: Inferred from mutant phenotype
24648492 GOA
acts upstream of or within protein localization to centrosome IMP
IMP: Inferred from mutant phenotype
24648492 GOA
acts upstream of or within protein localization to cilium IMP
IMP: Inferred from mutant phenotype
24648492 GOA
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
16618118 GOA
involved in spindle assembly IDA
IDA: Inferred from direct assay
10826492 GOA
Cellular Component GO Annotation Evidence Reference Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
10826492 GOA
located in centrosome IDA
IDA: Inferred from direct assay
21399614 GOA
located in ciliary basal body IDA
IDA: Inferred from direct assay
29257953 GOA
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
16027726 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
16027726 GOA
located in spindle IDA
IDA: Inferred from direct assay
10826492 GOA
located in spindle microtubule IDA
IDA: Inferred from direct assay
10826492 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CSNK1D Protein Structure

Pkinase

Pkinase: Protein kinase domain (9 - 246)

  • 0
  • 100
  • 200
  • 300
  • 415 a.a.
Protein Preferred Names Protein Names

casein kinase I isoform delta

casein kinase I

tau-protein kinase CSNK1D

CSNK1D Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
CSNK1D P48730 DRICH1 Homo sapiens Q6PGQ1
Validated Y2H
32296183
Intra
CSNK1D P48730 DRICH1 Homo sapiens Q6PGQ1
Y2H Array
32296183
Intra
CSNK1D P48730 GAPVD1 Homo sapiens Q14C86
Anti Tag CoIP
33961781
Intra
CSNK1D P48730 GAPVD1 Homo sapiens Q14C86
Pull Down
32707033
Intra
CSNK1D P48730 GAPVD1 Homo sapiens Q14C86
Anti Tag CoIP
35271311
Intra
CSNK1D P48730 PER2 Homo sapiens O15055
Y2H Prey Pooling
32296183
Intra
CSNK1D P48730 PER2 Homo sapiens O15055
Anti Tag CoIP
33961781
Intra
CSNK1D P48730 PER2 Homo sapiens O15055
Y2H Array
32296183
Intra
CSNK1D P48730 PER2 Homo sapiens O15055
Protein Kinase Assay
21179498
Intra
CSNK1D P48730 CCDC14 Homo sapiens Q49A88-3
Validated Y2H
32296183
Intra
CSNK1D P48730 CCDC14 Homo sapiens Q49A88-3
Y2H Array
32296183
Intra
CSNK1D P48730 CCDC14 Homo sapiens Q49A88-3
Y2H Prey Pooling
32296183
Intra
CSNK1D P48730 IKZF4 Homo sapiens Q9H2S9
Y2H Array
32296183
Intra
CSNK1D P48730 IKZF4 Homo sapiens Q9H2S9
Y2H Prey Pooling
32296183
Intra
CSNK1D P48730 IKZF4 Homo sapiens Q9H2S9
Validated Y2H
32296183
Intra
CSNK1D P48730 TRIM3 Homo sapiens O75382
Y2H Array
32296183
Intra
CSNK1D P48730 TRIM3 Homo sapiens O75382
Y2H Prey Pooling
32296183
Intra
CSNK1D P48730 MDM2 Homo sapiens Q00987
Pull Down
20708156
Intra
CSNK1D P48730 MDM2 Homo sapiens Q00987
Anti Tag CoIP
20708156
Intra
CSNK1D P48730 MDM2 Homo sapiens Q00987
Anti Bait CoIP
20708156
Intra
CSNK1D P48730 ZNF618 Homo sapiens Q5T7W0
Y2H Array
32296183
Intra
CSNK1D P48730 ZNF618 Homo sapiens Q5T7W0
Anti Tag CoIP
33961781
Intra
CSNK1D P48730 ZNF618 Homo sapiens Q5T7W0
Validated Y2H
32296183
Intra
CSNK1D P48730 ZNF618 Homo sapiens Q5T7W0
Y2H Prey Pooling
32296183
Cross
CSNK1D P48730 Dvl2 Mus musculus Q60838
Protein Kinase Assay
22609948
Intra
CSNK1D P48730 TRIM9 Homo sapiens Q9C026
Validated Y2H
25416956
Intra
CSNK1D P48730 TRIM9 Homo sapiens Q9C026
Y2H Prey Pooling
25416956
Intra
CSNK1D P48730 TRIM9 Homo sapiens Q9C026
Y2H Array
25416956
Intra
CSNK1D P48730 DVL3 Homo sapiens Q92997
Y2H Prey Pooling
25416956
Intra
CSNK1D P48730 DVL3 Homo sapiens Q92997
Y2H Pooling
16189514
Intra
CSNK1D P48730 DVL3 Homo sapiens Q92997
Validated Y2H
25416956
Intra
CSNK1D P48730 LZTS2 Homo sapiens Q9BRK4
Y2H Array
32296183
Intra
CSNK1D P48730 LZTS2 Homo sapiens Q9BRK4
Y2H Prey Pooling
32296183
Intra
CSNK1D P48730 LZTS2 Homo sapiens Q9BRK4
Validated Y2H
32296183
Intra
CSNK1D P48730 LURAP1 Homo sapiens Q96LR2
Validated Y2H
25416956
Intra
CSNK1D P48730 LURAP1 Homo sapiens Q96LR2
Anti Tag CoIP
25416956
Intra
CSNK1D P48730 LURAP1 Homo sapiens Q96LR2
Y2H Prey Pooling
25416956
Intra
CSNK1D P48730 PAK5 Homo sapiens Q9P286
Validated Y2H
32296183
Intra
CSNK1D P48730 PAK5 Homo sapiens Q9P286
Y2H Array
32296183
Intra
CSNK1D P48730 PAK5 Homo sapiens Q9P286
Y2H Prey Pooling
32296183
Intra
CSNK1D P48730 ZBTB8A Homo sapiens Q96BR9
Y2H Prey Pooling
32296183
Intra
CSNK1D P48730 ZBTB8A Homo sapiens Q96BR9
Validated Y2H
32296183
Intra
CSNK1D P48730 ZBTB8A Homo sapiens Q96BR9
Y2H Array
32296183
Intra
CSNK1D P48730 EVI5 Homo sapiens O60447
Y2H Array
32296183
Intra
CSNK1D P48730 EVI5 Homo sapiens O60447
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Advanced Sleep Phase Syndrome, Familial, 2

Advanced Sleep Phase Syndrome 2

FASPS2

Advanced Sleep-Phase Syndrome, Familial, 2

Familial Advanced Sleep Phase Syndrome 2

Sleep Phase Syndrome, Advanced, Familial, Type 2

Advanced Sleep Phase Syndrome

Fasps

Familial Advanced Sleep-Phase Syndrome

Advanced Sleep Phase Syndrome, Familial

Familial Advanced Sleep Phase Syndrome

Sleep Phase Syndrome, Advanced, Familial

Advanced Sleep-Phase Syndrome, Familial

Migraine, Familial Hemiplegic, 1

FHM1

Mhp1

Fhm

Familial Hemiplegic Migraine 1

Migraine, Familial Hemiplegic, 1, With Progressive Cerebellar Ataxia

Familial Hemiplegic Migraine1 With Progressive Cerebellar Ataxia

Migraine Familial Hemiplegic With Progressive Cerebellar Ataxia

Migraine, Hemiplegic, Familial, Type 1

Hemiplegic Migraine, Familial Type 1

Delayed Sleep Phase Disorder

Delayed Sleep Phase Syndrome

Delayed Sleep Phase Syndrome, Susceptibility To

DSPD

Delayed Sleep Phase Disorder, Susceptibility To

DSPS

Sleep Phase, Delayed, Disorder

Sleep Phase Syndrome, Delayed, Susceptibility To

Migraine, Familial Hemiplegic, 2

FHM2

Mhp2

Migraine, Familial Basilar

Familial Hemiplegic Migraine 2

Familial Hemiplegic Migraine-2

Familiar Basilar Migraine

Migraine, Hemiplegic, Familial, Type 2

Sleep Disorder

Sleep Disorders

Non-Organic Sleep Disorder

Migraine, Familial Hemiplegic, 3

FHM3

Familial Hemiplegic Migraine 3

Mhp3

Migraine, Hemiplegic, Familial, Type 3

Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour

Major Depressive Disorder

Seasonal Affective Disorder

Unipolar Depression

Depression

MDD

Depressive Disorder

Unipolar Depression, Susceptibility To

Major Depressive Disorder 1

Major Depressive Disorder, Response To Citalopram Therapy In

Major Depressive Disorder 2

Winter Depression

Single Major Depressive Episode

Sad

Clinical Depression

Major Depression

Depressive Syndrome

Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment

Seasonal Affective Disorder, Susceptibility To

Recurrent Major Depression

Affective Disorder, Seasonal

Depression In A Seasonal Pattern

Depression

Seasonal

Major Depressive Disorder With A Seasonal Pattern

Seasonal Depression

Seasonal Mood Disorder

Mental Depression

Recurrent Major Depressive Episodes

Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Alzheimer Disease, Familial, 1

Alzheimer Disease

Alzheimer'S Disease

Presenile And Senile Dementia

AD1

Alzheimer Disease, Susceptibility To

Alzheimer Disease, Late-Onset, Susceptibility To

Alzheimer Disease 1, Familial

AD

Familial Alzheimer Disease

Alzheimer Disease, Late-Onset

Alzheimers Dementia

Alzheimer Dementia

Alzheimer Sclerosis

Alzheimer Syndrome

Alzheimer-Type Dementia

Dat

Primary Senile Degenerative Dementia

Sdat

Alzheimer Disease 1

Autosomal Dominant Alzheimer Disease

Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

Late Onset Alzheimer Disease

Alzheimers Disease

Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

Late-Onset Alzheimers Disease

Alzheimer'S Disease Pathway Kegg

Dementia Due To Alzheimer'S Disease

Alzheimer Disease Type 1

Alzheimers

Migraine With Or Without Aura 1

Migraine

Migraine With Or Without Aura, Susceptibility To, 1

Migraine Disorder

Migraine Variant

Migraines

Migraine Disorders

Mgr1

Mgau

Ma

Migraine With Or Without Aura

Classic Migraine

Common Migraine

Disorder, Migraine

Headache Migraine

Headache Migrainous

Migraine Headache

Migraine Syndrome

Headache Including Migraine

Migraine, Susceptibility To

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Canis familiaris CSNK1D VGNC VGNC:39667
Felis catus CSNK1D VGNC VGNC:97391
Macaca mulatta CSNK1D VGNC VGNC:81382
Mus musculus CSNK1D MGD MGI:1355272
Rattus norvegicus CSNK1D RGD RGD:71031
Bos taurus CSNK1D VGNC VGNC:27766
Others CSNK1D NCBI