ARID3B - AT-rich interaction domain 3B Gene

Homo sapiens

Also known as BDP; DRIL2

Gene ID: 10620 | Gene type: protein coding

About ARID3B

Cytogenetic location: 15q24.1 Genomic coordinates (GRCh38): 15:74,541,220-74,598,131 (from NCBI)

This gene has 6 transcripts (splice variants), 270 orthologues and 2 paralogues. Broad expression in testis (RPKM 16.7), placenta (RPKM 10.6) and 19 other tissues.

Summary

This gene encodes a member of the ARID (AT-rich interaction domain) family of DNA-binding proteins. The encoded protein is homologous with two proteins that bind to the retinoblastoma gene product, and also with the mouse Bright and Drosophila dead ringer proteins. A pseudogene on chromosome 1p31 exists for this gene. Members of the ARID family have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation and possibly in chromatin structure modification. [provided by RefSeq, Jul 2008]

ARID3B Products(2)

mRNA	Protein	Name
NM_001307939.2	NP_001294868.1	AT-rich interactive domain-containing protein 3B isoform 1
NM_006465.4	NP_006456.1	AT-rich interactive domain-containing protein 3B isoform 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21044950	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARID3B Protein Structure

ARID

0
100
200
300
400
500
560 a.a.

Protein Preferred Names

Protein Names

AT-rich interactive domain-containing protein 3B

ARID domain-containing protein 3B

ARID3B Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ARID3B	Q8IVW6	TINF2	Homo sapiens	Q9BSI4	Pull Down	21044950
Intra	ARID3B	Q8IVW6	TINF2	Homo sapiens	Q9BSI4	BiFC	21044950

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Neuroblastoma

Nb	Neuroblastoma, Susceptibility To
Neuroblastomas	Central Neuroblastoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00970	ARID3B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ARID3B	VGNC	VGNC:38096
Rattus norvegicus	ARID3B	RGD	RGD:1306335
Macaca mulatta	ARID3B	VGNC	VGNC:69827
Felis catus	ARID3B	VGNC	VGNC:59915
Mus musculus	ARID3B	MGD	MGI:1930768
Bos taurus	ARID3B	VGNC	VGNC:26127

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