CENPF - centromere protein F Gene

Homo sapiens

Also known as CENF; hcp-1; CILD31; STROMS; PRO1779

Gene ID: 1063 | Gene type: protein coding

About CENPF

Cytogenetic location: 1q41 Genomic coordinates (GRCh38): 1:214,603,195-214,664,571 (from NCBI)

This gene has 5 transcripts (splice variants), 189 orthologues and is associated with 4 phenotypes. Broad expression in bone marrow (RPKM 9.7), testis (RPKM 6.0) and 15 other tissues.

Summary

This gene encodes a protein that associates with the centromere-kinetochore complex. The protein is a component of the nuclear matrix during the G2 phase of interphase. In late G2 the protein associates with the kinetochore and maintains this association through early anaphase. It localizes to the spindle midzone and the intracellular bridge in late anaphase and telophase, respectively, and is thought to be subsequently degraded. The localization of this protein suggests that it may play a role in chromosome segregation during mitotis. It is thought to form either a homodimer or heterodimer. Autoantibodies against this protein have been found in patients with Cancer or graft versus host disease. [provided by RefSeq, Jul 2008]

CENPF Products(1)

mRNA	Protein	Name
NM_016343.4	NP_057427.3	centromere protein F

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	15677469	GOA
enables dynein complex binding	IDA IDA: Inferred from direct assay	12974617	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7642639	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	7642639	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in chromosome segregation	IMP IMP: Inferred from mutant phenotype	16252009	GOA
involved in kidney development	IMP IMP: Inferred from mutant phenotype	25564561	GOA
involved in metaphase chromosome alignment	IDA IDA: Inferred from direct assay	15870278	GOA
involved in mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	7542657	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15677469	GOA
involved in protein transport	IDA IDA: Inferred from direct assay	12974617	GOA
involved in protein transport	IMP IMP: Inferred from mutant phenotype	17600710	GOA
involved in regulation of G2/M transition of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	7651420	GOA
involved in ventricular system development	IMP IMP: Inferred from mutant phenotype	25564561	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromosome, centromeric region	IDA IDA: Inferred from direct assay	7542657	GOA
part of ciliary transition fiber	IMP IMP: Inferred from mutant phenotype	25564561	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	12974617	GOA
located in kinetochore	IDA IDA: Inferred from direct assay	7542657	GOA
located in midbody	IDA IDA: Inferred from direct assay	7651420	GOA
located in nuclear envelope	IDA IDA: Inferred from direct assay	12154071	GOA
located in nuclear matrix	IDA IDA: Inferred from direct assay	7542657	GOA
located in nucleus	IDA IDA: Inferred from direct assay	7542657	GOA
part of outer kinetochore	IDA IDA: Inferred from direct assay	7542657	GOA
located in spindle	IDA IDA: Inferred from direct assay	7651420	GOA
located in spindle pole	IDA IDA: Inferred from direct assay	7542657	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CENPF Protein Structure

CENP-F_N

CENP-F_leu_zip

CENP-F_C_Rb_bdg

0
500
1000
1500
2000
2500
3114 a.a.

Protein Preferred Names

Protein Names

centromere protein F

AH antigen

Related Diseases

Diseases

Alias

Stromme Syndrome

Jejunal Atresia With Microcephaly And Ocular Anomalies	Apple Peel Syndrome With Microcephaly And Ocular Anomalies
STROMS	Cild31
Lethal Fetal Brain Malformation-Duodenal Atresia-Bilateral Renal Hypoplasia Syndrome	Ciliary Dyskinesia, Primary, 31, Formerly
Cild31, Formerly	Primary Ciliary Dyskinesia 31
Apple-Peel Intestinal Atresia-Ocular Anomalies-Microcephaly Syndrome	Jejunal Atresia-Microcephaly-Ocular Anomalies Syndrome
Ciliary Dyskinesia, Primary, 31	Dyskinesia, Ciliary, Primary, Type 31

Graft-Versus-Host Disease

Graft-Versus-Host Disease, Susceptibility To	Graft Versus Host Disease
GVHDS	Graft-Versus-Host Disease, Protection Against
Gvh	Graft-Vs-Host Disease
Gvhd - [Graft-Versus-Host Disease]	Graft-Versus-Host Reaction Or Disease
Gvh - [Graft-Versus-Host] Disease	Gvh - [Graft-Versus-Host] Reaction

Intestinal Atresia

Cystinuria

CSNU	Cystinuria Type B
Cystinuria Type A	Cystinuria, Type I, Formerly
Csnu1, Formerly	Cystinuria, Type Ii, Formerly
Cystinuria, Type Iii, Formerly	Csnu3, Formerly
Cystinuria, Type Non-I, Formerly	Cystinuria-Lysinuria
Cystinuria-Lysinuria Syndrome	Csnu1
Csnu3	Cystinuria 1
Cystinuria Type A/B	Cystinuria Type I
Cystinuria Type Ii	Cystinuria Type Iii
Cystinuria Type Non-I	Cystinuria, Type A/B
Cystinuria Type 1	Cystinuria - Lysinuria
Csnu - [Cystinuria]	Cystine Disease

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Mosaic Variegated Aneuploidy Syndrome 1

Mva Syndrome	MVA1
Mosaic Variegated Aneuploidy Syndrome, Type 1	Mosaic Variegated Aneuploidy Syndrome
Congenital Chromosomal Disease

Gastric Cancer

Stomach Cancer	Gastric Carcinoma
Stomach Carcinoma	Gastric Cancer, Somatic
Gastric Neoplasm	Carcinoma Of Stomach
Stomach Neoplasms	Malignant Neoplasm Of Stomach
Gastric Cancer Risk After H. Pylori Infection	Cancer Of The Stomach
Adult Stomach Cancer	Adult Stomach Carcinoma
GASC	Gastric Cancer Intestinal
Gastric Cancers	Gastric Carcinomas
Cancer, Gastric	Stomach Neoplasm
Malignant Neoplasm Of Body Of Stomach	Malignant Tumor Of Lesser Curve Of Stomach
Gastrocarcinoma Of Unspecified Site	Leather Bottle Stomach
Carcinoma Of Fundus Of Stomach	Cancer Of Fundus Of Stomach
Primary Malignant Neoplasm Of Body Of Stomach	Cancer Of Body Of Stomach
Primary Malignant Neoplasm Of Pyloric Antrum	Pyloric Antrum Cancer
Malignant Tumour Of Stomach

Familial Apolipoprotein C-Ii Deficiency

Familial Apoc-Ii Deficiency	Familial Apoc2 Deficiency
C-Ii Anapolipoproteinemia	Hyperlipoproteinemia, Type 1b
Hyperlipoproteinemia, Type Ib	Hyperlipoproteinemia Type I

Primary Autosomal Recessive Microcephaly

Autosomal Recessive Primary Microcephaly	Mcph
True Microcephaly	Microcephalia Vera
Microcephaly Vera	Microcephaly Primary Hereditary
Microcephaly, Primary, Autosomal Recessive	Primary Microcephaly

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02479	CENPF Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CENPF	VGNC	VGNC:27176
Mus musculus	CENPF	MGD	MGI:1313302
Felis catus	CENPF	VGNC	VGNC:107851
Rattus norvegicus	CENPF	RGD	RGD:628667
Macaca mulatta	CENPF	VGNC	VGNC:71009

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