EIF5A - eukaryotic translation initiation factor 5A Gene

Homo sapiens

Also known as FABAS; EIF-5A; EIF5A1; eIF-4D; eIF5AI

Gene ID: 1984 | Gene type: protein coding

About EIF5A

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:7,306,999-7,312,463 (from NCBI)

This gene has 11 transcripts (splice variants), 1 gene allele, 207 orthologues, 2 paralogues and is associated with 2 phenotypes. Ubiquitous expression in esophagus (RPKM 53.8), appendix (RPKM 49.4) and 25 other tissues.

Summary

Enables U6 snRNA binding activity and protein N-terminus binding activity. Involved in several processes, including cellular response to virus; positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator; and tumor necrosis factor-mediated signaling pathway. Located in annulate lamellae; cytoplasm; and nucleus. Part of nuclear pore. [provided by Alliance of Genome Resources, Apr 2022]

EIF5A Products(6)

mRNA	Protein	Name
NM_001143760.1	NP_001137232.1	eukaryotic translation initiation factor 5A-1 isoform A
NM_001143761.1	NP_001137233.1	eukaryotic translation initiation factor 5A-1 isoform B
NM_001143762.2	NP_001137234.1	eukaryotic translation initiation factor 5A-1 isoform B
NM_001370420.1	NP_001357349.1	eukaryotic translation initiation factor 5A-1 isoform B
NM_001370421.1	NP_001357350.1	eukaryotic translation initiation factor 5A-1 isoform B
NM_001970.5	NP_001961.1	eukaryotic translation initiation factor 5A-1 isoform B

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA binding	IDA IDA: Inferred from direct assay	15303967	GOA
enables U6 snRNA binding	IDA IDA: Inferred from direct assay	9285100	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9442029	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to virus	IMP IMP: Inferred from mutant phenotype	8596953	GOA
involved in positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator	IDA IDA: Inferred from direct assay	15371445	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	15371445	GOA
involved in translational elongation	IMP IMP: Inferred from mutant phenotype	29712776	GOA
involved in tumor necrosis factor-mediated signaling pathway	IDA IDA: Inferred from direct assay	17187778	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in annulate lamellae	IDA IDA: Inferred from direct assay	12210765	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	12210765	GOA
part of nuclear pore	IDA IDA: Inferred from direct assay	10381392	GOA
located in nucleus	IDA IDA: Inferred from direct assay	12210765	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EIF5A Protein Structure

eIF-5a

0
100
154 a.a.

Protein Preferred Names

Protein Names

eukaryotic translation initiation factor 5A-1

eukaryotic initiation factor 5A

Recombinant EIF5A Proteins

Cat. No.	Product Name	Accession	Purity
HY-P78232	EIF5A Protein, Human (His)	NP_001961 (M1-K154)	≥95%

Related Diseases

Diseases

Alias

Faundes-Banka Syndrome

FABAS

Human Immunodeficiency Virus Type 1

Aids	Hiv/Aids
Aids, Delayed/Rapid Progression To	Hiv-1, Susceptibility To
Hiv-1 Viremia, Susceptibility To	Human Immunodeficiency Virus Type 1, Susceptibility To
Hiv-1	Aids, Slow Progression To
Rapid Progression To Aids From Hiv1 Infection	Hiv1 Infection, Resistance To
Hiv1 Infection	Hiv-1 Viremia
Aids, Resistance To	Aids, Rapid Progression To
Hiv/Aids, Susceptibility To	Hiv-1, Resistance To
Hiv1, Resistance To	Hiv1
Hiv-1 Disease, Delayed Progression Of	Hiv-1 Disease, Rapid Progression Of
Hiv Infection, Resistance To	Hiv Type 1, Susceptibility To
Hiv Type 1	Hiv-1 Infection
Human Immunodeficiency Virus I Infection	Acquired Immunodeficiency Syndrome
Hiv-Infection/Aids

Syndromic X-Linked Intellectual Disability Snyder Type

Snyder-Robinson Syndrome	Mental Retardation, X-Linked, Snyder-Robinson Type
Spermine Synthase Deficiency	Srs
Snyder-Robinson Mental Retardation Syndrome	X-Linked Intellectual Disability Snyder-Robinson Type
Mental Retardation, X-Linked, Syndromic, Snyder-Robinson Type	Snyder-Robinson X-Linked Mental Retardation Syndrome

Immune Deficiency Disease

Immunodeficiency	Primary Immunodeficiency
Primary Immunodeficiency Disease	Immunologic Deficiency Syndromes
Hypoimmunity	Immune Deficiency Disorder
Immunodeficiency Syndrome	Immune Disorder
Primary Immune Deficiency Disorder	Immune System Diseases
Human Immunodeficiency Virus Infection	Hiv - [Human Immunodeficiency Virus Infection]
Hiv Positive Nos	Hiv Disease
Acquired Immune Deficiency Syndrome-Related Complex	Aids-Like Syndrome
Aids-Related Complex Nos	Arc - [Aids-Related Complex]
Immunodeficiency Due To Human Immunodeficiency Virus Infection	Unspecified Human Immunodeficiency Virus Disease
Hiv Disease Nos	Human Immunodeficiency Virus Positive Nos
Hiv Nos	Deficiency Of Complement Initial Pathway
Deficiency Of Complement Terminal Pathway	Cfdd - [Complement Factor D Deficiency]
Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency	Nonfamilial Hypogammaglobulinaemia
Common Variable Immune Deficiency	Nonfamilial Agammaglobulinaemia
Common Variable Agammaglobulinaemia	Agammaglobulinaemia Nos
Agammaglobulinaemia Antibody Deficiency Syndrome	Hypogammaglobulinaemia Antibody Deficiency Syndrome
Acquired Agammaglobulinaemia Nos	Hypogammaglobulinaemia Nos
Hyper Igm

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-111522	RK-9123016	Inhibitor	99.02%	Unkown
HY-RS04286	EIF5A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS04287	EIF5A2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-121722	Deoxyhypusine		/	Unkown
HY-122039	Hypusine dihydrochloride		/	Unkown
HY-126171	Hypusine		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	EIF5A	MGD	MGI:106248
Rattus norvegicus	EIF5A	RGD	RGD:1308029
Others	EIF5A	NCBI

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