2. Gene
  3. CD226 - CD226 molecule Gene

CD226 - CD226 molecule Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PTA1; DNAM1; DNAM-1; TLiSA1

Gene ID: 10666 | Gene type: protein coding

About CD226

Cytogenetic location: 18q22.2 Genomic coordinates (GRCh38): 18:69,853,274-69,961,773 (from NCBI)

This gene has 8 transcripts (splice variants), 185 orthologues and 14 paralogues. Broad expression in spleen (RPKM 2.4), lymph node (RPKM 1.3) and 15 other tissues.

Summary

This gene encodes a glycoprotein expressed on the surface of NK cells, platelets, monocytes and a subset of T cells. It is a member of the Ig-superfamily containing 2 Ig-like domains of the V-set. The protein mediates cellular adhesion of platelets and megakaryocytic cells to vascular endothelial cells. The protein also plays a role in megakaryocytic cell maturation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

CD226 Products(3)

mRNA Protein Name
NM_001303618.2 NP_001290547.1 CD226 antigen isoform a precursor
NM_001303619.2 NP_001290548.1 CD226 antigen isoform b
NM_006566.4 NP_006557.2 CD226 antigen isoform a precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables cell adhesion molecule binding IPI
IPI: Inferred from physical interaction
12913096 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
25465800 GOA
enables integrin binding IPI
IPI: Inferred from physical interaction
16831868 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21982860 GOA
enables protein kinase binding IPI
IPI: Inferred from physical interaction
16831868 GOA
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of Fc receptor mediated stimulatory signaling pathway IDA
IDA: Inferred from direct assay
16831868 GOA
involved in positive regulation of T cell receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
26755705 GOA
involved in positive regulation of immunoglobulin mediated immune response IDA
IDA: Inferred from direct assay
16831868 GOA
involved in positive regulation of mast cell activation IDA
IDA: Inferred from direct assay
16831868 GOA
involved in positive regulation of natural killer cell mediated cytotoxicity IMP
IMP: Inferred from mutant phenotype
16304049 GOA
involved in positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target IMP
IMP: Inferred from mutant phenotype
12913096 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cell surface IDA
IDA: Inferred from direct assay
16831868 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CD226 Protein Structure

V-set

V-set: Immunoglobulin V-set domain (31 - 124)

Ig_2

Ig_2: Immunoglobulin domain (140 - 239)

  • 0
  • 100
  • 200
  • 300
  • 336 a.a.
Protein Preferred Names Protein Names

CD226 antigen

DNAX accessory molecule-1

CD226 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
CD226 Q15762 PVR Homo sapiens P15151
SPR
30591568
Intra
CD226 Q15762 PVR Homo sapiens P15151
Protein Array
21982860
Intra
CD226 Q15762 ATP12A Homo sapiens P54707
Anti Tag CoIP
33961781
Intra
CD226 Q15762 EIF2B3 Homo sapiens Q9NR50
Anti Tag CoIP
33961781
Intra
CD226 Q15762 BSCL2 Homo sapiens Q96G97
Anti Tag CoIP
33961781
Intra
CD226 Q15762 ARL10 Homo sapiens Q8N8L6
Anti Tag CoIP
33961781
Intra
CD226 Q15762 TIGIT Homo sapiens Q495A1
Anti Tag CoIP
25465800
Intra
CD226 Q15762 ATR Homo sapiens Q13535
Anti Tag CoIP
33961781
Intra
CD226 Q15762 EIF2B2 Homo sapiens P49770
Anti Tag CoIP
33961781
Intra
CD226 Q15762 CD226 Homo sapiens Q15762
FRET
25465800
Intra
CD226 Q15762 EIF2B4 Homo sapiens Q9UI10
Anti Tag CoIP
33961781
Intra
CD226 Q15762 ATP2B3 Homo sapiens Q16720
Anti Tag CoIP
33961781
Intra
CD226 Q15762 NECTIN2 Homo sapiens Q92692
Protein Array
21982860
Intra
CD226 Q15762 EIF2B5 Homo sapiens Q13144
Anti Tag CoIP
33961781
Intra
CD226 Q15762 CD226 Homo sapiens Q15762
X-Ray Diffraction
30591568
Intra
CD226 Q15762 DSTYK Homo sapiens Q6XUX3
Anti Tag CoIP
33961781
Intra
CD226 Q15762 C4A Homo sapiens P0C0L4
Anti Tag CoIP
33961781
Intra
CD226 Q15762 TIGIT Homo sapiens Q495A1
FRET
25465800
Intra
CD226 Q15762 CDK5RAP3 Homo sapiens Q96JB5
Anti Tag CoIP
33961781
Intra
CD226 Q15762 ATP13A1 Homo sapiens Q9HD20
Anti Tag CoIP
33961781
Intra
CD226 Q15762 EIF2B1 Homo sapiens Q14232
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CD226 Proteins

Cat. No. Product Name Accession Purity
HY-P70829 DNAM-1 Protein, Human (HEK293, Fc) Q15762 (E19-N247) ≥95%
HY-P72668 DNAM-1 Protein, Human (HEK293, His) Q15762 (E19-N247) ≥95%
HY-P78114 DNAM-1 Protein, Human (Biotinylated, HEK293, His-Avi) Q15762 (E19-N247) ≥95%
HY-P78429 DNAM-1 Protein, Human (HEK293, His-Avi) Q15762 (E19-N247) ≥95%
HY-P700441 DNAM-1 Protein, Human (HEK293, hFc, Myc) Q15762 (E19-N247) ≥95%

CD226 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81691 DNAM1 Antibody (YA1436) FC, ELISA Human
HY-P82667 CD226 Antibody (YA2412) WB Human

Related Diseases

Diseases Alias
Mature Teratoma Of The Ovary
Ovarian Cystic Teratoma
Nk Cell Deficiency
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
Systemic Lupus Erythematosus

Lupus Nephritis

SLE

Disseminated Lupus Erythematosus

Systemic Lupus Erythematosus, Susceptibility To

Lupus Erythematosus, Systemic

Lupus Nephritis, Susceptibility To

Libman-Sacks Disease

Systemic Lupus Erythematosus Susceptibility To

Sle - Lupus Erythematosus, Systemic

Le Syndrome

Lupus

Lupus Erythematosus Systemic

Lupus Erythematosus, Systemic, Susceptibility To

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus

Systemic Lupus Erythematosus Nos

Sle - [Systemic Lupus Erythematosus]
Leukemia, Acute Myeloid

Acute Myeloid Leukemia

Leukemia, Acute Myelogenous

Acute Myelogenous Leukemia

AML

Leukemia, Acute Myeloid, Susceptibility To

Acute Myeloblastic Leukemia

Leukemia, Acute Myeloid, Reduced Survival In, Somatic

Acute Myeloid Leukaemia

Leukemia, Myelocytic, Acute

Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

Secondary Aml

Acute Myelocytic Leukemia

Acute Myeloid Leukemia, Somatic

Leukemia, Acute Myeloid, Somatic

Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

Acute Myeloblastic Leukaemia

Acute Myelogenous Leukaemia

Aml - Acute Myeloid Leukemia

Acute Myeloid Leukemia With Cebpa Somatic Mutations

Aml With Cebpa Somatic Mutations

Inherited Acute Myeloid Leukemia

Familial Aml

Inherited Aml

Pure Familial Aml

Pure Familial Acute Myeloid Leukemia

Secondary Acute Myeloid Leukemia

Therapy-Related Aml And Myelodysplastic Syndrome

Acute Myeloid Leukemia, Secondary

Acute Non-Lymphoblastic Leukemia

Acute Non-Lymphocytic Leukemia

Acute Biphenotypic Leukemia

Acute Undifferentiated Leukemia

Acute Myeloblastic Leukaemia With Multilineage Dysplasia

Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02211 CD226 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus CD226 MGD MGI:3039602
Bos taurus CD226 VGNC VGNC:27013
Macaca mulatta CD226 VGNC VGNC:101435
Rattus norvegicus CD226 RGD RGD:1311513
Canis familiaris CD226 VGNC VGNC:38940
Felis catus CD226 VGNC VGNC:60598
Macaca fascicularis CD226 NCBI NCBI:102117316
Others CD226 NCBI