CDK5RAP3 - CDK5 regulatory subunit associated protein 3 Gene

Homo sapiens

Also known as C53; IC53; LZAP; HSF-27; MST016; PP1553; OK/SW-cl.114

Gene ID: 80279 | Gene type: protein coding

About CDK5RAP3

Cytogenetic location: 17q21.32 Genomic coordinates (GRCh38): 17:47,967,904-47,981,781 (from NCBI)

This gene has 37 transcripts (splice variants) and 201 orthologues. Ubiquitous expression in spleen (RPKM 44.2), lymph node (RPKM 40.3) and 25 other tissues.

Summary

This gene encodes a protein that has been reported to function in signaling pathways governing transcriptional regulation and cell cycle progression. It may play a role in tumorigenesis and metastasis. A pseudogene of this gene is located on the long arm of chromosome 20. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, May 2013]

CDK5RAP3 Products(5)

mRNA	Protein	Name
NM_001278197.2	NP_001265126.1	CDK5 regulatory subunit-associated protein 3 isoform c
NM_001278198.2	NP_001265127.1	CDK5 regulatory subunit-associated protein 3 isoform d
NM_001278216.2	NP_001265145.1	CDK5 regulatory subunit-associated protein 3 isoform e
NM_001278217.2	NP_001265146.1	CDK5 regulatory subunit-associated protein 3 isoform f
NM_176096.3	NP_788276.1	CDK5 regulatory subunit-associated protein 3 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables MDM2/MDM4 family protein binding	IPI IPI: Inferred from physical interaction	16173922	GOA
enables NF-kappaB binding	IPI IPI: Inferred from physical interaction	17785205	GOA
enables cyclin binding	IPI IPI: Inferred from physical interaction	15790566	GOA
enables mitogen-activated protein kinase binding	IPI IPI: Inferred from physical interaction	21283629	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16173922	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	19223857	GOA
enables ubiquitin-like ligase-substrate adaptor activity	IDA IDA: Inferred from direct assay	36121123	GOA
enables ubiquitin-like protein ligase binding	IDA IDA: Inferred from direct assay	20531390	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in apoptotic nuclear changes	IMP IMP: Inferred from mutant phenotype	23478299	GOA
involved in cell population proliferation	IDA IDA: Inferred from direct assay	12054757	GOA
involved in endoplasmic reticulum unfolded protein response	IMP IMP: Inferred from mutant phenotype	23152784	GOA
involved in mitotic G2 DNA damage checkpoint signaling	IMP IMP: Inferred from mutant phenotype	15790566	GOA
involved in mitotic G2/M transition checkpoint	IMP IMP: Inferred from mutant phenotype	19223857	GOA
involved in negative regulation of MAP kinase activity	IMP IMP: Inferred from mutant phenotype	21283629	GOA
involved in negative regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	17785205	GOA
involved in negative regulation of protein catabolic process	IDA IDA: Inferred from direct assay	16173922	GOA
involved in negative regulation of protein kinase activity by regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	21283629	GOA
involved in negative regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	17785205	GOA
involved in negative regulation of protein serine/threonine kinase activity	IMP IMP: Inferred from mutant phenotype	19223857	GOA
involved in positive regulation of protein localization to nucleus	IDA IDA: Inferred from direct assay	16173922	GOA
involved in positive regulation of protein ubiquitination	IDA IDA: Inferred from direct assay	16173922	GOA
involved in positive regulation of reticulophagy	IDA IDA: Inferred from direct assay	36543799	GOA
involved in positive regulation of reticulophagy	IMP IMP: Inferred from mutant phenotype	32851973	GOA
involved in positive regulation of signal transduction by p53 class mediator	IDA IDA: Inferred from direct assay	16173922	GOA
NOT involved in positive regulation of ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	16173922	GOA
acts upstream of or within protein ufmylation	IDA IDA: Inferred from direct assay	23152784	GOA
involved in protein ufmylation	IDA IDA: Inferred from direct assay	36121123	GOA
involved in protein ufmylation	IMP IMP: Inferred from mutant phenotype	30635284	GOA
involved in regulation of phosphatase activity	IMP IMP: Inferred from mutant phenotype	21283629	GOA
involved in rescue of stalled ribosome	IDA IDA: Inferred from direct assay	37595036	GOA
involved in rescue of stalled ribosome	IMP IMP: Inferred from mutant phenotype	32851973	GOA
involved in ribosome disassembly	IDA IDA: Inferred from direct assay	38383785	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in centrosome	IDA IDA: Inferred from direct assay	19223857	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	15790566	GOA
is active in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	36543799	GOA
colocalizes with microtubule	IDA IDA: Inferred from direct assay	23478299	GOA
NOT located in nucleolus	IDA IDA: Inferred from direct assay	16173922	GOA
located in nucleus	IDA IDA: Inferred from direct assay	16173922	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	20531390	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDK5RAP3 Protein Structure

DUF773

0
100
200
300
400
506 a.a.

Protein Preferred Names

Protein Names

CDK5 regulatory subunit-associated protein 3

CDK5 regulatory subunit associated protein IC53-2

CDK5RAP3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CDK5RAP3	Q96JB5	UFC1	Homo sapiens	Q9Y3C8	Anti Bait CoIP	17353931
Intra	CDK5RAP3	Q96JB5	UFC1	Homo sapiens	Q9Y3C8	Pull Down	37595036
Intra	CDK5RAP3	Q96JB5	UFC1	Homo sapiens	Q9Y3C8	Anti Tag CoIP	37595036
Intra	CDK5RAP3	Q96JB5	UFL1	Homo sapiens	O94874	Anti Tag CoIP	37595036
Intra	CDK5RAP3	Q96JB5	UFL1	Homo sapiens	O94874	Pull Down	37595036
Intra	CDK5RAP3	Q96JB5	UFL1	Homo sapiens	O94874	Anti Tag CoIP	33961781
Intra	CDK5RAP3	Q96JB5	UFL1	Homo sapiens	O94874	Anti Bait CoIP	17353931
Intra	CDK5RAP3	Q96JB5	TSPYL4	Homo sapiens	Q9UJ04	Validated Y2H	32296183
Intra	CDK5RAP3	Q96JB5	TSPYL4	Homo sapiens	Q9UJ04	Validated Y2H	25416956
Intra	CDK5RAP3	Q96JB5	RELA	Homo sapiens	Q04206	Anti Bait CoIP	17785205
Intra	CDK5RAP3	Q96JB5	FKBP6	Homo sapiens	O75344	Y2H Array	31515488
Intra	CDK5RAP3	Q96JB5	FKBP6	Homo sapiens	O75344	Y2H Prey Pooling	25416956
Intra	CDK5RAP3	Q96JB5	FKBP6	Homo sapiens	O75344	Y2H Array	25416956
Intra	CDK5RAP3	Q96JB5	FKBP6	Homo sapiens	O75344	MAPPIT	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Beukes Hip Dysplasia

Hip Dysplasia, Beukes Type	Beukes Familial Hip Dysplasia
BFHD	Cilliers-Beighton Syndrome
Osteoarthropathy, Premature Degenerative, Of Hip	Premature Degenerative Osteoarthropathy Of The Hip
BHD	Beukes Type Hip Dysplasia
Hip Dysplasia Beukes Type	Premature Degenerative Osteoarthropathy
Dysplasia, Hip, Beukes Type

Renal Cysts And Diabetes Syndrome

RCAD	Mody5
Congenital Anomalies Of The Kidney And Urinary Tract With Diabetes	Cakut With Diabetes
Maturity-Onset Diabetes Of The Young Type 5	Tubulointerstitial Kidney Disease, Autosomal Dominant, 3
Adtkd3	Atypical Familial Juvenile Hyperuricemic Nephropathy
Atypical Fjhn	Familial Hypoplastic Glomerulocystic Kidney
Maturity-Onset Diabetes Of The Young, Type 5	Hyperuricemic Nephropathy, Familial Juvenile, Atypical
Fjhn, Atypical	Glomerulocystic Kidney Disease, Hypoplastic Type
Glomerulocystic Kidney, Familial Hypoplastic	Hypoplastic Type Glomerulocystic Kidney Disease
Glomerulocystic Kidney Disease Hypoplastic Type	Renal-Diabetes Mody5 Syndrome

Maturity-Onset Diabetes Of The Young

MODY	Maturity Onset Diabetes Mellitus In Young
Mason-Type Diabetes	Mason Type Diabetes
Maturity Onset Diabetes Of The Young	Mody Syndrome
Diabetes Of The Young, Maturity-Onset

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02391	CDK5RAP3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CDK5RAP3	RGD	RGD:620002
Bos taurus	CDK5RAP3	VGNC	VGNC:27132
Macaca mulatta	CDK5RAP3	VGNC	VGNC:71015
Felis catus	CDK5RAP3	VGNC	VGNC:60704
Canis familiaris	CDK5RAP3	VGNC	VGNC:39059
Mus musculus	CDK5RAP3	MGD	MGI:1933126

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