GMEB1 - glucocorticoid modulatory element binding protein 1 Gene

Homo sapiens

Also known as PIF96; P96PIF

Gene ID: 10691 | Gene type: protein coding

About GMEB1

Cytogenetic location: 1p35.3 Genomic coordinates (GRCh38): 1:28,668,229-28,719,353 (from NCBI)

This gene has 4 transcripts (splice variants), 250 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 4.0), testis (RPKM 3.2) and 25 other tissues.

Summary

This gene encodes a member of KDWK gene family which associates with GMEB2 protein. The GMEB1-GMEB2 complex is essential for parvovirus DNA replication. Studies in rat for a similar gene suggest that this gene's role is to modulate the transactivation of the Glucocorticoid Receptor when it is bound to glucocorticoid response elements. Three alternative spliced transcript variants encoding different isoforms exist. [provided by RefSeq, Feb 2016]

GMEB1 Products(3)

mRNA	Protein	Name
NM_001319674.2	NP_001306603.1	glucocorticoid modulatory element-binding protein 1 isoform 2
NM_006582.4	NP_006573.2	glucocorticoid modulatory element-binding protein 1 isoform 1
NM_024482.3	NP_077808.1	glucocorticoid modulatory element-binding protein 1 isoform 2

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables Hsp27 protein binding	IPI IPI: Inferred from physical interaction	10386584	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	10386584	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	10386584	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10894151	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	10386584	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GMEB1 Protein Structure

SAND

0
100
200
300
400
500
573 a.a.

Protein Preferred Names

Protein Names

glucocorticoid modulatory element-binding protein 1

DNA-binding protein p96PIF

GMEB1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	GMEB1	Q9Y692	GMEB2	Homo sapiens	Q9UKD1	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

GMEB1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83197	GMEB1 Antibody (YA2942)	WB, IP	Human

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05516	GMEB1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	GMEB1	VGNC	VGNC:29432
Canis familiaris	GMEB1	VGNC	VGNC:41286
Mus musculus	GMEB1	MGD	MGI:2135604
Felis catus	GMEB1	VGNC	VGNC:62605
Rattus norvegicus	GMEB1	RGD	RGD:1563208
Macaca mulatta	GMEB1	VGNC	VGNC:99963

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