2. Gene
  3. GMEB2 - glucocorticoid modulatory element binding protein 2 Gene

GMEB2 - glucocorticoid modulatory element binding protein 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PIF79; GMEB-2; P79PIF

Gene ID: 26205 | Gene type: protein coding

About GMEB2

Cytogenetic location: 20q13.33 Genomic coordinates (GRCh38): 20:63,587,605-63,627,101 (from NCBI)

This gene has 3 transcripts (splice variants), 209 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 6.7), testis (RPKM 6.1) and 25 other tissues.

Summary

This gene is a member of KDWK gene family. The product of this gene associates with GMEB1 protein, and the complex is essential for parvovirus DNA replication. Study of rat homolog implicates the role of this gene in modulation of transactivation by the Glucocorticoid Receptor bound to glucocorticoid response elements. This gene appears to use multiple polyadenylation sites. [provided by RefSeq, Jul 2008]

GMEB2 Products(1)

mRNA Protein Name
NM_012384.5 NP_036516.1 glucocorticoid modulatory element-binding protein 2

GMEB2 Protein Structure

SAND

SAND: SAND domain (85 - 163)

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  • 530 a.a.
Protein Preferred Names Protein Names

glucocorticoid modulatory element-binding protein 2

DNA-binding protein p79PIF

GMEB2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
GMEB2 Q9UKD1 MXRA8 Homo sapiens Q9BRK3
Y2H Array
32296183
Intra
GMEB2 Q9UKD1 MXRA8 Homo sapiens Q9BRK3
Y2H Prey Pooling
32296183
Intra
GMEB2 Q9UKD1 LMO2 Homo sapiens P25791-3
Y2H Prey Pooling
32296183
Intra
GMEB2 Q9UKD1 LMO2 Homo sapiens P25791-3
Y2H Array
32296183
Intra
GMEB2 Q9UKD1 TTF2 Homo sapiens Q9UNY4-2
Validated Y2H
32296183
Intra
GMEB2 Q9UKD1 POU6F2 Homo sapiens P78424
Y2H Prey Pooling
32296183
Intra
GMEB2 Q9UKD1 POU6F2 Homo sapiens P78424
Y2H Array
32296183
Intra
GMEB2 Q9UKD1 TRAF3 Homo sapiens Q13114
Y2H Array
32296183
Intra
GMEB2 Q9UKD1 TRAF3 Homo sapiens Q13114
Y2H Prey Pooling
32296183
Intra
GMEB2 Q9UKD1 FHL2 Homo sapiens Q14192
Y2H Prey Pooling
32296183
Intra
GMEB2 Q9UKD1 FHL2 Homo sapiens Q14192
Y2H Array
32296183
Intra
GMEB2 Q9UKD1 ATXN1 Homo sapiens P54253
Y2H
16713569
Intra
GMEB2 Q9UKD1 GMEB2 Homo sapiens Q9UKD1
Y2H Prey Pooling
32296183
Intra
GMEB2 Q9UKD1 GMEB2 Homo sapiens Q9UKD1
Validated Y2H
32296183
Intra
GMEB2 Q9UKD1 GMEB2 Homo sapiens Q9UKD1
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Eosinophilic Variant Of Chromophobe Renal Cell Carcinoma
Vulvovaginitis

Vulvo-Vaginitis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05517 GMEB2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta GMEB2 VGNC VGNC:84914
Rattus norvegicus GMEB2 RGD RGD:620481
Mus musculus GMEB2 MGD MGI:2652836
Felis catus GMEB2 VGNC VGNC:62606
Bos taurus GMEB2 VGNC VGNC:29433
Canis familiaris GMEB2 VGNC VGNC:41287