MAP3K2 - mitogen-activated protein kinase kinase kinase 2 Gene

Homo sapiens

Also known as MEKK2; MEKK2B

Gene ID: 10746 | Gene type: protein coding

About MAP3K2

Cytogenetic location: 2q14.3 Genomic coordinates (GRCh38): 2:127,298,668-127,388,465 (from NCBI)

This gene has 3 transcripts (splice variants), 217 orthologues and 8 paralogues. Ubiquitous expression in bone marrow (RPKM 11.2), thyroid (RPKM 10.3) and 25 other tissues.

Summary

The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates Other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process. [provided by RefSeq, Jul 2008]

MAP3K2 Products(3)

mRNA	Protein	Name
NM_001371910.2	NP_001358839.1	mitogen-activated protein kinase kinase kinase 2
NM_001371911.1	NP_001358840.1	mitogen-activated protein kinase kinase kinase 2
NM_006609.5	NP_006600.3	mitogen-activated protein kinase kinase kinase 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15778465	GOA
enables protein kinase activity	IDA IDA: Inferred from direct assay	15001576	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	17906693	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to mechanical stimulus	IEP IEP: Inferred from expression pattern	19593445	GOA
involved in intracellular signal transduction	IDA IDA: Inferred from direct assay	14515274	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAP3K2 Protein Structure

PB1

Pkinase

0
100
200
300
400
500
619 a.a.

Protein Preferred Names

Protein Names

mitogen-activated protein kinase kinase kinase 2

MAP/ERK kinase kinase 2

MAP3K2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MAP3K2	Q9Y2U5	MAP2K5	Homo sapiens	Q13163	Y2H Array	21988832
Intra	MAP3K2	Q9Y2U5	MAP2K5	Homo sapiens	Q13163	Pull Down	32707033
Intra	MAP3K2	Q9Y2U5	YWHAE	Homo sapiens	P62258	Crosslink	36931259
Intra	MAP3K2	Q9Y2U5	YWHAE	Homo sapiens	P62258	Anti Tag CoIP	26496610
Intra	MAP3K2	Q9Y2U5	YWHAE	Homo sapiens	P62258	Pull Down	32707033
Intra	MAP3K2	Q9Y2U5	STUB1	Homo sapiens	Q9UNE7	Anti Tag CoIP	20588253
Intra	MAP3K2	Q9Y2U5	STUB1	Homo sapiens	Q9UNE7	Anti Bait CoIP	20588253
Intra	MAP3K2	Q9Y2U5	SFN	Homo sapiens	P31947	TAP	15778465
Intra	MAP3K2	Q9Y2U5	SFN	Homo sapiens	P31947	Anti Tag CoIP	26496610

Cross: Cross-species interaction Intra: Intraspecies interaction

MAP3K2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83470	MEKK2 Antibody (YA3215)	WB, ICC/IF, IP	Human, Mouse, Rat

Related Diseases

Diseases

Alias

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-112080A	(R)-BAY-6035	Inhibitor	/	Unkown
HY-RS08054	MAP3K2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	MAP3K2	VGNC	VGNC:42972
Macaca mulatta	MAP3K2	VGNC	VGNC:81461
Mus musculus	MAP3K2	MGD	MGI:1346873
Rattus norvegicus	MAP3K2	RGD	RGD:620967
Felis catus	MAP3K2	VGNC	VGNC:80275
Bos taurus	MAP3K2	VGNC	VGNC:31195
Others	MAP3K2	NCBI

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