2. Gene
  3. TRAF3IP2 - TRAF3 interacting protein 2 Gene

TRAF3IP2 - TRAF3 interacting protein 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ACT1; CIKS; C6orf2; C6orf4; C6orf5; C6orf6; CANDF8; PSORS13

Gene ID: 10758 | Gene type: protein coding

About TRAF3IP2

Cytogenetic location: 6q21 Genomic coordinates (GRCh38): 6:111,555,381-111,605,878 (from NCBI)

This gene has 21 transcripts (splice variants), 91 orthologues and is associated with 3 phenotypes. Ubiquitous expression in endometrium (RPKM 6.1), stomach (RPKM 4.8) and 25 other tissues.

Summary

This gene encodes a protein involved in regulating responses to cytokines by members of the Rel/NF-kappaB transcription factor family. These factors play a central role in innate immunity in response to pathogens, inflammatory signals and stress. This gene product interacts with TRAF proteins (tumor necrosis factor receptor-associated factors) and either I-kappaB kinase or MAP kinase to activate either NF-kappaB or Jun kinase. Several alternative transcripts encoding different isoforms have been identified. Another transcript, which does not encode a protein and is transcribed in the opposite orientation, has been identified. Overexpression of this transcript has been shown to reduce expression of at least one of the protein encoding transcripts, suggesting it has a regulatory role in the expression of this gene. [provided by RefSeq, Aug 2009]

TRAF3IP2 Products(4)

mRNA Protein Name
NM_001164281.3 NP_001157753.1 E3 ubiquitin ligase TRAF3IP2 isoform 3
NM_001164283.3 NP_001157755.1 E3 ubiquitin ligase TRAF3IP2 isoform 5
NM_147200.3 NP_671733.2 E3 ubiquitin ligase TRAF3IP2 isoform 1
NM_147686.4 NP_679211.2 E3 ubiquitin ligase TRAF3IP2 isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
12459498 GOA
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
19825828 GOA
Biological Process GO Annotation Evidence Reference Source
involved in inflammatory response IDA
IDA: Inferred from direct assay
17277779 GOA
involved in interleukin-17-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
19825828 GOA
involved in interleukin-17A-mediated signaling pathway IDA
IDA: Inferred from direct assay
17277779 GOA
involved in positive regulation of canonical NF-kappaB signal transduction IEP
IEP: Inferred from expression pattern
12761501 GOA
involved in positive regulation of defense response to virus by host IDA
IDA: Inferred from direct assay
23066157 GOA
involved in protein K63-linked ubiquitination IDA
IDA: Inferred from direct assay
19825828 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRAF3IP2 Protein Structure

SEFIR

SEFIR: SEFIR domain (410 - 552)

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  • 500
  • 574 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin ligase TRAF3IP2

E3 ubiquitin-protein ligase CIKS

TRAF3IP2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra TRAF3IP2 O43734 RIMBP3 Homo sapiens Q9UFD9
Y2H Array
25416956
Intra TRAF3IP2 O43734 FHL3 Homo sapiens Q96C98
Y2H Prey Pooling
25416956
Intra TRAF3IP2 O43734 TRAF6 Homo sapiens Q9Y4K3
Validated Y2H
25416956
Intra TRAF3IP2 O43734 MRPL28 Homo sapiens Q13084
Validated Y2H
25416956
Intra TRAF3IP2 O43734 MRPL28 Homo sapiens Q13084
Y2H Prey Pooling
25416956
Intra TRAF3IP2 O43734 MRPL28 Homo sapiens Q13084
Y2H Array
25416956
Intra TRAF3IP2 O43734 TRIP6 Homo sapiens Q15654
Y2H Array
25416956
Intra TRAF3IP2 O43734 STK16 Homo sapiens O75716
Validated Y2H
25416956
Intra TRAF3IP2 O43734 STK16 Homo sapiens O75716
Y2H Array
25416956
Intra TRAF3IP2 O43734 STK16 Homo sapiens O75716
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Candidiasis, Familial, 8

CANDF8

Candidiasis, Familial Chronic Mucocutaneous, Autosomal Recessive

Candidiasis Familial Chronic Mucocutaneous Autosomal Recessive

Candidiasis, Familial, Type 8
Psoriasis 13

PSORS13

Psoriasis 13, Susceptibility To

Psoriasis

Psoriasis Vulgaris

Psoriasis Susceptibility 13

Pv

Psoriasis, Susceptibility To, Type 13
Discoid Lupus Erythematosus

Lupus Erythematosus Discoid

Lupus Erythematosus, Discoid

Cdle - [Chronic Discoid Lupus Erythematosus]

Dle - [Discoid Lupus Erythematosus]

Chronic Discoid Lupus Erythematosus

Discoid Lupus Nos
Chronic Mucocutaneous Candidiasis

Candidiasis, Chronic Mucocutaneous

Cmc

Candidiasis Chronic Mucocutaneous
Candidiasis

Systemic Candidiasis

Invasive Candidiasis

Disseminated Candidiasis

Systemic Candida Infections

Candidiasis, Invasive
Folliculitis
Pericarditis
Immunodeficiency 29

Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Il12b Deficiency

IMD29

Il12b Deficiency

Immunodeficiency 29, Mycobacteriosis

Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Interleukin 12b Deficiency

Msmd Due To Complete Il12b Deficiency

Msmd Due To Complete Interleukin 12b Deficiency

Immunodeficiency, Type 29, Mycobacteriosis
Psoriasis
Psoriasis 10

PSORS10

Psoriasis Susceptibility 10

Psoriasis 10, Susceptibility To
Candidal Paronychia

Candidiasis Of Skin

Candidiasis Of Skin And Nails

Candidal Perionyxis
Psoriasis 7

PSORS7

Psoriasis 7, Susceptibility To

Psoriasis Susceptibility 7

Psoriasis

Psoriasis Vulgaris

Pv
Nail Disease

Nail Diseases

Abnormality Of The Nail

Nail Anomaly
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-NP135 Oxidized low density lipoprotein (Human) / Unkown
HY-RS14971 TRAF3IP2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus TRAF3IP2 VGNC VGNC:36274
Mus musculus TRAF3IP2 MGD MGI:2143599
Macaca mulatta TRAF3IP2 VGNC VGNC:78921
Felis catus TRAF3IP2 VGNC VGNC:66498
Rattus norvegicus TRAF3IP2 RGD RGD:1593240
Canis familiaris TRAF3IP2 VGNC VGNC:47766