2. Gene
  3. MRPL28 - mitochondrial ribosomal protein L28 Gene

MRPL28 - mitochondrial ribosomal protein L28 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as p15; MAAT1

Gene ID: 10573 | Gene type: protein coding

About MRPL28

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:366,969-370,538 (from NCBI)

This gene has 10 transcripts (splice variants) and 202 orthologues. Ubiquitous expression in testis (RPKM 24.9), kidney (RPKM 19.3) and 25 other tissues.

Summary

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein, a part of which was originally isolated by its ability to recognize Tyrosinase in an HLA-A24-restricted fashion. [provided by RefSeq, Jul 2008]

MRPL28 Products(1)

mRNA Protein Name
NM_006428.5 NP_006419.2 39S ribosomal protein L28, mitochondrial
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
20601428 GOA
Cellular Component GO Annotation Evidence Reference Source
part of mitochondrial large ribosomal subunit IDA
IDA: Inferred from direct assay
25278503 GOA
located in mitochondrial ribosome IDA
IDA: Inferred from direct assay
20601428 GOA
located in mitochondrion IDA
IDA: Inferred from direct assay
28892042 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

39S ribosomal protein L28, mitochondrial

L28mt

MRPL28 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra MRPL28 Q13084 FAM9B Homo sapiens Q8IZU0
Y2H Prey Pooling
25416956
Intra MRPL28 Q13084 NFKBID Homo sapiens Q8NI38
Y2H Array
32296183
Intra MRPL28 Q13084 NFKBID Homo sapiens Q8NI38
Validated Y2H
32296183
Intra MRPL28 Q13084 NFKBID Homo sapiens Q8NI38
Y2H Prey Pooling
32296183
Intra MRPL28 Q13084 ABI2 Homo sapiens Q9NYB9-2
Validated Y2H
32296183
Intra MRPL28 Q13084 CDR2 Homo sapiens Q01850
Y2H Array
25416956
Intra MRPL28 Q13084 LARP1B Homo sapiens Q659C4-6
Validated Y2H
32296183
Intra MRPL28 Q13084 HMBOX1 Homo sapiens Q6NT76
Validated Y2H
25416956
Intra MRPL28 Q13084 HMBOX1 Homo sapiens Q6NT76
Y2H Array
25416956
Intra MRPL28 Q13084 TEF Homo sapiens Q10587
Y2H Prey Pooling
25416956
Intra MRPL28 Q13084 TEF Homo sapiens Q10587
Y2H Array
25416956
Intra MRPL28 Q13084 TRAF4 Homo sapiens Q9BUZ4
Y2H Array
25416956
Intra MRPL28 Q13084 TRAF4 Homo sapiens Q9BUZ4
Y2H Prey Pooling
25416956
Intra MRPL28 Q13084 TSSK3 Homo sapiens Q96PN8
Validated Y2H
32296183
Intra MRPL28 Q13084 CDCA7L Homo sapiens Q96GN5
Validated Y2H
32296183
Intra MRPL28 Q13084 ZNF655 Homo sapiens Q8N720
Y2H Array
32296183
Intra MRPL28 Q13084 ZNF655 Homo sapiens Q8N720
Validated Y2H
32296183
Intra MRPL28 Q13084 ZNF655 Homo sapiens Q8N720
Y2H Prey Pooling
32296183
Intra MRPL28 Q13084 LENG1 Homo sapiens Q96BZ8
Validated Y2H
32296183
Intra MRPL28 Q13084 ENKD1 Homo sapiens Q9H0I2
Validated Y2H
32296183
Intra MRPL28 Q13084 BANP Homo sapiens Q8N9N5
Validated Y2H
25416956
Intra MRPL28 Q13084 BANP Homo sapiens Q8N9N5
Y2H Array
25416956
Intra MRPL28 Q13084 IKZF3 Homo sapiens Q9UKT9
Y2H Prey Pooling
25416956
Intra MRPL28 Q13084 IKZF3 Homo sapiens Q9UKT9
Validated Y2H
25416956
Intra MRPL28 Q13084 IKZF3 Homo sapiens Q9UKT9
Y2H Array
25416956
Intra MRPL28 Q13084 SCNM1 Homo sapiens Q9BWG6
Validated Y2H
32296183
Intra MRPL28 Q13084 TSHZ3 Homo sapiens Q63HK5
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Pancreatic Serous Cystadenoma
Megalencephalic Leukoencephalopathy With Subcortical Cysts 1

Van Der Knaap Disease

Leukoencephalopathy With Swelling And Cysts

MLC1

Vacuolating Megalencephalic Leukoencephalopathy With Subcortical Cysts

Lvm

Vl

Leukoencephalopathy, Megalencephalic, With Subcortical Cysts, 1

Leukoencephalopathy, Megalencephalic, With Subcortical Cysts, Type 1

Megalencephalic Leukoencephalopathy With Subcortical Cysts
Melanoma

Malignant Melanoma

Cutaneous Melanoma

Naevocarcinoma

Malignant Melanomas
Spastic Paraplegia 10, Autosomal Dominant

SPG10

Hereditary Spastic Paraplegia 10

Autosomal Dominant Spastic Paraplegia Type 10

Spastic Paraplegia 10

Spastic Paraplegia 10 With Or Without Peripheral Neuropathy

Autosomal Dominant Spastic Paraplegia 10

Autosomal Dominant Spastic Paraplegia

Spastic Paraplegia, Autosomal Dominant

Paraplegia, Spastic, Autosomal Dominant, Type 10
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08668 MRPL28 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus MRPL28 RGD RGD:1583741
Macaca mulatta MRPL28 VGNC VGNC:74758
Bos taurus MRPL28 VGNC VGNC:31629
Mus musculus MRPL28 MGD MGI:1915861
Canis familiaris MRPL28 VGNC VGNC:43389
Felis catus MRPL28 VGNC VGNC:107765