LILRB1 - leukocyte immunoglobulin like receptor B1 Gene

Homo sapiens

Also known as ILT2; LIR1; MIR7; PIRB; CD85J; ILT-2; LIR-1; MIR-7; PIR-B

Gene ID: 10859 | Gene type: protein coding

About LILRB1

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:54,616,322-54,638,022 (from NCBI)

This gene has 13 transcripts (splice variants), 1 gene allele, 304 orthologues and 25 paralogues. Biased expression in appendix (RPKM 25.9), spleen (RPKM 20.5) and 10 other tissues.

Summary

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

LILRB1 Products(10)

mRNA	Protein	Name
NM_001081637.3	NP_001075106.2	leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 2 precursor
NM_001081638.4	NP_001075107.2	leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 3 precursor
NM_001081639.4	NP_001075108.2	leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 4 precursor
NM_001278398.2	NP_001265327.2	leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 5 precursor
NM_001278399.2	NP_001265328.2	leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 6 precursor
NM_001388355.1	NP_001375284.1	leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 3 precursor
NM_001388356.1	NP_001375285.1	leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 4 precursor
NM_001388357.1	NP_001375286.1	leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 3 precursor
NM_001388358.1	NP_001375287.1	leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 2 precursor
NM_006669.7	NP_006660.4	leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables HLA-A specific inhibitory MHC class I receptor activity	IDA IDA: Inferred from direct assay	18684926	GOA
enables HLA-B specific inhibitory MHC class I receptor activity	IDA IDA: Inferred from direct assay	11907092	GOA
enables MHC class I protein binding	IDA IDA: Inferred from direct assay	9842885	GOA
enables MHC class I protein binding	IMP IMP: Inferred from mutant phenotype	18398485	GOA
enables MHC class I protein binding	IPI IPI: Inferred from physical interaction	9285411	GOA
enables MHC class I receptor activity	IDA IDA: Inferred from direct assay	9285411	GOA
enables MHC class Ib protein binding	IDA IDA: Inferred from direct assay	11169396	GOA
enables MHC class Ib protein complex binding	IDA IDA: Inferred from direct assay	17056715	GOA
enables MHC class Ib receptor activity	IDA IDA: Inferred from direct assay	24453251	GOA
enables SH2 domain binding	IDA IDA: Inferred from direct assay	11907092	GOA
NOT enables amyloid-beta binding	IDA IDA: Inferred from direct assay	24052308	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11169396	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	21213105	GOA
enables protein phosphatase 1 binding	IPI IPI: Inferred from physical interaction	9285411	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in Fc receptor mediated inhibitory signaling pathway	IDA IDA: Inferred from direct assay	9842885	GOA
involved in T cell proliferation involved in immune response	IDA IDA: Inferred from direct assay	18094328	GOA
involved in cellular response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	18094328	GOA
involved in defense response to virus	IDA IDA: Inferred from direct assay	15585844	GOA
involved in dendritic cell differentiation	IEP IEP: Inferred from expression pattern	18094328	GOA
involved in negative regulation of CD8-positive, alpha-beta T cell activation	IDA IDA: Inferred from direct assay	21213105	GOA
involved in negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	IDA IDA: Inferred from direct assay	18094328	GOA
involved in negative regulation of T cell mediated cytotoxicity	IDA IDA: Inferred from direct assay	21213105	GOA
involved in negative regulation of T cell proliferation	IDA IDA: Inferred from direct assay	15585844	GOA
involved in negative regulation of alpha-beta T cell activation	IDA IDA: Inferred from direct assay	21213105	GOA
involved in negative regulation of calcium ion transport	IDA IDA: Inferred from direct assay	9842885	GOA
involved in negative regulation of cell cycle	IDA IDA: Inferred from direct assay	21551166	GOA
involved in negative regulation of cytokine production involved in immune response	IDA IDA: Inferred from direct assay	18094328	GOA
involved in negative regulation of dendritic cell apoptotic process	IDA IDA: Inferred from direct assay	18094328	GOA
involved in negative regulation of dendritic cell differentiation	IMP IMP: Inferred from mutant phenotype	18684926	GOA
involved in negative regulation of endocytosis	IDA IDA: Inferred from direct assay	18094328	GOA
involved in negative regulation of interferon-beta production	IDA IDA: Inferred from direct assay	21213105	GOA
involved in negative regulation of interleukin-10 production	IDA IDA: Inferred from direct assay	18094328	GOA
involved in negative regulation of interleukin-12 production	IDA IDA: Inferred from direct assay	18094328	GOA
involved in negative regulation of mononuclear cell proliferation	IDA IDA: Inferred from direct assay	21551166	GOA
involved in negative regulation of natural killer cell mediated cytotoxicity	IDA IDA: Inferred from direct assay	12874224	GOA
involved in negative regulation of osteoclast development	IDA IDA: Inferred from direct assay	18802077	GOA
involved in negative regulation of serotonin secretion	IDA IDA: Inferred from direct assay	11907092	GOA
involved in negative regulation of transforming growth factor beta production	IDA IDA: Inferred from direct assay	18094328	GOA
involved in negative regulation of tumor necrosis factor production	IDA IDA: Inferred from direct assay	18684926	GOA
involved in negative regulation of type II interferon production	IDA IDA: Inferred from direct assay	17869268	GOA
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	21551166	GOA
involved in positive regulation of defense response to virus by host	IDA IDA: Inferred from direct assay	18398485	GOA
involved in positive regulation of gamma-delta T cell activation involved in immune response	IDA IDA: Inferred from direct assay	21233315	GOA
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	18094328	GOA
involved in positive regulation of macrophage cytokine production	IDA IDA: Inferred from direct assay	19304799	GOA
involved in positive regulation of type II interferon production	IDA IDA: Inferred from direct assay	11907092	GOA
involved in response to virus	IDA IDA: Inferred from direct assay	9285411	GOA
involved in signal transduction	IDA IDA: Inferred from direct assay	18802077	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	15585844	GOA
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	9285411	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LILRB1 Protein Structure

Ig_2

Ig_3

Ig_2

Ig_3

0
200
400
600
701 a.a.

Protein Preferred Names

Protein Names

leukocyte immunoglobulin-like receptor subfamily B member 1

CD85 antigen-like family member J

LILRB1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	LILRB1	Q8NHL6	HLA-G	Homo sapiens	P17693	SPR	16455647
Intra	LILRB1	Q8NHL6	PTPN6	Homo sapiens	P29350	Anti Bait CoIP	18802077

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant LILRB1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70179	LILRB1/CD85j/ILT2 Protein, Human (435a.a, HEK293, His)	ADJ55949.1 (G24-H458)	≥95%
HY-P77980	LILRB1/CD85j/ILT2 Protein (Domain1&2), Human (HEK293, His)	Q8NHL6-1 (G24-G221)	≥95%
HY-P77981	LILRB1/CD85j/ILT2 Protein, Human (346a.a, HEK293, His)	Q8NHL6-1 (L116-V461)	≥95%
HY-P77982	LILRB1/CD85j/ILT2 Protein, Human (HEK293, mFc)	Q8NHL6-1 (G24-H458)	≥95%
HY-P77985	LILRB1/CD85j/ILT2 Protein, Human (HEK293, His-Avi)	Q8NHL6-1 (G24-H458)	≥95%

Related Diseases

Diseases

Alias

Human Cytomegalovirus Infection

Cytomegalovirus Infection

Cytomegalovirus Infections

Malaria

Malaria, Susceptibility To	Malaria, Resistance To
Malaria, Cerebral	Cerebral Malaria
Malaria, Severe, Susceptibility To	Malaria, Severe, Resistance To
Malaria, Cerebral, Susceptibility To	Induced Malaria
Malaria, Vivax, Protection Against	Malaria, Severe
Malaria, Cerebral, Reduced Risk Of	Malaria, Protection Against
Resistance To Malaria Due To G6pd Deficiency	Malaria Due To G6pd Deficiency
Malarial Encephalitis	CM
Malaria Cerebral	Susceptibility To Malaria
Acute Pernicious Fever	Aestivo-Autumnal Fever
Aestivo Autumnal Malaria	Chagres Fever
Continued Malaria Fever	Estivo-Autumnal Fever
Estivo-Autumnal Malaria	Estivo-Autumnal Malarial Fever
Falciparum Fever	Malignant Tertian Fever
Malignant Tertian Malaria	Pernicious Intermittent Fever
Pernicious Malaria	Quotidian Malaria
Subtertian Fever	Subtertian Malaria Fever
Subtertian Malignant Tertian Malaria	Tropical Malaria
Algid Malaria	Bilious Haemoglobinuric Fever
Black Water Fever	Blackwater Fever
Malarial Blackwater Fever	Severe Malarial Falciparum
West African Fever	Malarial Haematinuria
Haemoglobinuric Fever	Haemoglobinuric Malaria
Severe Plasmodium Falciparum Malaria	Malarial Haemoglobinuria
Malarial Haematuria	Falciparum Malaria [Malignant Tertian]
Malaria Tropica	Malarial Shock
Chagres Virus Disease	Malignant Malaria
Mtm - [Malignant Tertian Malaria]	Tm -[Malignant Tertian Malaria]
Panama Fever	St - [Subtertian Malaria]
Malarial Quotidian	Benign Tertian Malaria
Tertian Ague	Vivax Fever
Plasmodium Vivax Malaria Nos	Btm - [Benign Tertian Malaria]
Bt - [Benign Tertian Malaria]	Vivax Malaria
Benign Tertian Vivax Malaria	Tertian Malaria
Quartan Malaria	Quartan Ague
Quartan Fever	Plasmodium Malariae Malaria Nos
Quartan Malarial	Malaria By Plasmodium Malariae
Malariae Malaria	Ovale Tertian Malaria
Plasmodium Ovale Fever	Malaria Fever By Plasmodium Ovale
Ovale Malaria	Malaria By Plasmodium Ovale
Malarial Ovale	Marsh Fever
Remittent Congestive Fever	Coastal Fever
Remittent Gastric Fever	Miasmatic Fever
Congestive Remittent Fever	Intermittent Fever
Jungle Fever	Paludism
Cameroon Fever	Ague
Corsican Fever	Intermittent Bilious Fever
Disease Due To Plasmodiidae	Malarial Fever
Plasmodiosis	Remittent Fever
Roman Fever	Malaria Fever Nos
Malaria Nos	Paludal Fever
Clinically Diagnosed Malaria	Clinically Diagnosed Malaria Without Parasitological Confirmation
Congestive Fever	Malarial Cachexia
Marsh Cachexia	Paludal Cachexia
Recurrent Malaria	Remittent Malaria

Bare Lymphocyte Syndrome, Type I

Hla Class I Deficiency	Mhc Class I Deficiency
Bls, Type I	Bare Lymphocyte Syndrome Type I
Bare Lymphocyte Syndrome, Type I, Due To Tap2 Deficiency	Blsi
Mhc Class 1 Deficiency	Major Histocompatibility Complex Class 1 Deficiency
Bare Lymphocyte Syndrome 1	BLS1
Bls I	Bls Type I
Bl-1	Bare Lymphocyte Syndrome Type 1
Immunodeficiency By Defective Expression Of Hla - [Human Leukocyte Antigen] Class 1	Scid - [Severe Combined Immunodeficiency] Due To Absent Class 2 Hla Antigens
Bls - [Bare Lymphocyte Syndrome] Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07651	LILRB1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	LILRB1	MGD	MGI:894311
Macaca fascicularis	LILRB1	NCBI
Macaca mulatta	LILRB1	NCBI	NCBI:692340

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