SUGT1 - SGT1 homolog, MIS12 kinetochore complex assembly cochaperone Gene

Homo sapiens

Also known as SGT1

Gene ID: 10910 | Gene type: protein coding

About SUGT1

Cytogenetic location: 13q14.3 Genomic coordinates (GRCh38): 13:52,652,836-52,700,909 (from NCBI)

This gene has 4 transcripts (splice variants), 213 orthologues and 18 paralogues. Ubiquitous expression in brain (RPKM 4.1), testis (RPKM 3.2) and 25 other tissues.

Summary

This gene encodes a highly conserved nuclear protein involved in kinetochore function and required for the G1/S and G2/M transitions. This protein interacts with heat shock protein 90. Alternative splicing results in multiple transcript variants. Pseudogenes for this gene have been defined on several different chromosomes. [provided by RefSeq, Mar 2016]

SUGT1 Products(3)

mRNA	Protein	Name
NM_001130912.3	NP_001124384.1	protein SGT1 homolog isoform B
NM_001320831.2	NP_001307760.1	protein SGT1 homolog isoform C
NM_006704.5	NP_006695.1	protein SGT1 homolog isoform A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17420470	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in kinetochore assembly	IMP IMP: Inferred from mutant phenotype	15133482	GOA
involved in regulation of protein stability	IDA IDA: Inferred from direct assay	23935490	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of protein-containing complex	IDA IDA: Inferred from direct assay	23184943	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SUGT1 Protein Structure

TPR_11

SGS

0
100
200
300
365 a.a.

Protein Preferred Names

Protein Names

protein SGT1 homolog

SGT1, suppressor of G2 allele of SKP1

SUGT1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SUGT1	Q9Y2Z0	NOD1	Homo sapiens	Q9Y239	Anti Tag CoIP	17420470
Cross	SUGT1	Q9Y2Z0	sspH2	Salmonella typhimurium	A0A0H3NF38	Anti Bait CoIP	21566117

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Louping Ill

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14010	SUGT1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SUGT1	RGD	RGD:1307550
Macaca mulatta	SUGT1	VGNC	VGNC:103875
Bos taurus	SUGT1	VGNC	VGNC:35465
Felis catus	SUGT1	VGNC	VGNC:65832
Mus musculus	SUGT1	MGD	MGI:1915205

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