PDIA5 - protein disulfide isomerase family A member 5 Gene

Homo sapiens

Also known as PDIR

Gene ID: 10954 | Gene type: protein coding

About PDIA5

Cytogenetic location: 3q21.1 Genomic coordinates (GRCh38): 3:123,067,025-123,162,104 (from NCBI)

This gene has 8 transcripts (splice variants), 209 orthologues and 13 paralogues. Ubiquitous expression in placenta (RPKM 25.8), prostate (RPKM 23.2) and 24 other tissues.

Summary

This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, three catalytically active thioredoxin (TRX) domains, a TRX-like domain, and a C-terminal ER-retention sequence. The N-terminal TRX-like domain is the primary binding site for the major ER chaperone calreticulin and possibly Other proteins and substrates as well. Alternative splicing results in multiple protein- and non-protein-coding transcript variants. [provided by RefSeq, Dec 2016]

PDIA5 Products(1)

mRNA	Protein	Name
NM_006810.4	NP_006801.1	protein disulfide-isomerase A5 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables protein disulfide isomerase activity	IDA IDA: Inferred from direct assay	14627699	GOA
enables protein-disulfide reductase activity	IDA IDA: Inferred from direct assay	16677074	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in protein folding	IDA IDA: Inferred from direct assay	14627699	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PDIA5 Protein Structure

Thioredoxin

0
100
200
300
400
519 a.a.

Protein Preferred Names

Protein Names

protein disulfide-isomerase A5

protein disulfide isomerase-associated 5

PDIA5 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PDIA5	Q14554	MDFI	Homo sapiens	Q99750	Validated Y2H	25416956
Intra	PDIA5	Q14554	MDFI	Homo sapiens	Q99750	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PDIA5 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71192	PDIA5 Protein, Human (HEK293, His)	Q14554-2 (S22-L262)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10270	PDIA5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PDIA5	VGNC	VGNC:64085
Macaca mulatta	PDIA5	VGNC	VGNC:75858
Rattus norvegicus	PDIA5	RGD	RGD:1359236
Canis familiaris	PDIA5	VGNC	VGNC:44378
Mus musculus	PDIA5	MGD	MGI:1919849
Bos taurus	PDIA5	VGNC	VGNC:32699
Others	PDIA5	NCBI

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