2. Gene
  3. METAP2 - methionyl aminopeptidase 2 Gene

METAP2 - methionyl aminopeptidase 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as MAP2; MNPEP; p67eIF2

Gene ID: 10988 | Gene type: protein coding

About METAP2

Cytogenetic location: 12q22 Genomic coordinates (GRCh38): 12:95,474,152-95,515,839 (from NCBI)

This gene has 11 transcripts (splice variants), 213 orthologues and 7 paralogues. Ubiquitous expression in testis (RPKM 26.5), lymph node (RPKM 23.7) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the methionyl Aminopeptidase family. The encoded protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent proteins. Increased expression of this gene is associated with various forms of Cancer, and the anti-cancer drugs fumagillin and ovalicin inhibit the protein by irreversibly binding to its active site. Inhibitors of this gene have also been shown to be effective for the treatment of obesity. A pseudogene of this gene is located on chromosome 2. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

METAP2 Products(4)

mRNA Protein Name
NM_001317182.2 NP_001304111.1 methionine aminopeptidase 2 isoform 2
NM_001317183.2 NP_001304112.1 methionine aminopeptidase 2 isoform 3
NM_001330246.2 NP_001317175.1 methionine aminopeptidase 2 isoform 4
NM_006838.4 NP_006829.1 methionine aminopeptidase 2 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables aminopeptidase activity IDA
IDA: Inferred from direct assay
8858118 GOA
enables metalloexopeptidase activity IDA
IDA: Inferred from direct assay
8858118 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
Biological Process GO Annotation Evidence Reference Source
involved in N-terminal protein amino acid modification IDA
IDA: Inferred from direct assay
8858118 GOA
involved in peptidyl-methionine modification IDA
IDA: Inferred from direct assay
8858118 GOA
involved in protein processing IDA
IDA: Inferred from direct assay
8858118 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
15102683 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

METAP2 Protein Structure

Peptidase_M24

Peptidase_M24: Metallopeptidase family M24 (168 - 465)

  • 0
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  • 400
  • 478 a.a.
Protein Preferred Names Protein Names

methionine aminopeptidase 2

eIF-2-associated p67 homolog

Recombinant METAP2 Proteins

Cat. No. Product Name Accession Purity
HY-P70364 METAP2/Methionine aminopeptidase 2 Protein, Human (Sf9, His) P50579-1 (A2-Y478) ≥95%

Related Diseases

Diseases Alias
Microsporidiosis

Infection By Microspora

Microsporidiasis

Infection By Microsporea

Infection By Microsporida

Intestinal Microsporidiosis

Microsporidia Infection

Infection By Microsporidia
Amelogenesis Imperfecta, Type Ia

Amelogenesis Imperfecta Type 1a

AI1A

Amelogenesis Imperfecta, Hypoplastic Type Ia

Amelogenesis Imperfecta Type Ia

Amelogenesis Imperfecta Hypoplastic Type Ia

Amelogenesis Imperfecta 1a
Liver Rhabdomyosarcoma

Rhabdomyosarcoma Of Liver
Amebiasis

Amoebiasis

Entamoebiasis

Chronic Intestinal Amebiasis

Amoebiasis, Unspecified

Amebic Colitis

Amoebic Enteritis

Infection Due To Entamoeba Histolytica

Amoebic Infection

Disease Due To Endamoebidae

Amoebiasis Nos
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Phase
HY-14811 Beloranib Inhibitor / Phase 3
HY-114196 Aclimostat Inhibitor ≥98.0% Phase 2
HY-133016 M8891 Inhibitor 98.97% Phase 1
HY-13731 PPI-2458 Inhibitor 99.67% Phase 1
Pre-clinical Phase
Bioactive Molecules (15)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-120868 TP-004 Inhibitor 98.89% Unkown
HY-134183 AUTAC1 Inducer ≥95.0% Unkown
HY-128147 MetAP-2-IN-6 Inhibitor 99.55% Unkown
HY-161742 Fumagilin-105 Inducer 97.34% Unkown
HY-P4344 Met-Gly-Pro-AMC Inhibitor 99.69% Unkown
HY-133016A (R)-M8891 Inhibitor 98.67% Unkown
HY-150409 TSPO ligand-2 99.63% Unkown
HY-109188 Relzomostat Inhibitor / Unkown
HY-14811A Beloranib hemioxalate Inhibitor / Unkown
HY-158006 SDX-7539 Inhibitor / Unkown
HY-161743 PBA-1105 Inducer / Unkown
HY-161744 PBA-1106 Inducer / Unkown
HY-161745 PBA-1105b / Unkown
HY-161746 Anle138b-F105 / Unkown
HY-RS08350 METAP2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus METAP2 MGD MGI:1929701
Canis familiaris METAP2 VGNC VGNC:43168
Bos taurus METAP2 VGNC VGNC:31397
Felis catus METAP2 VGNC VGNC:63456
Macaca mulatta METAP2 VGNC VGNC:74518
Rattus norvegicus METAP2 RGD RGD:70995
Others METAP2 NCBI