Ehmt2 - euchromatic histone lysine N-methyltransferase 2 Gene

Mus musculus

Also known as G9a; Bat8; NG36; KMT1C; D17Ertd710e

Gene ID: 110147 | Gene type: protein coding

About Ehmt2

Chromosome 17: 35,117,445-35,133,028 forward strand.GRCm39:CM001010.3

This gene has 14 transcripts (splice variants), 210 orthologues, 20 paralogues and is associated with 22 phenotypes. Ubiquitous expression in ovary adult (RPKM 86.7), testis adult (RPKM 83.8) and 28 other tissues.

Summary

Enables several functions, including C2H2 zinc finger domain binding activity; histone-lysine N-methyltransferase activity; and promoter-specific chromatin binding activity. Involved in DNA methylation; histone methylation; and regulation of DNA replication. Acts upstream of or within several processes, including macromolecule methylation; negative regulation of autophagosome assembly; and response to cocaine. Located in nucleus. Is expressed in several structures, including alimentary system; limb; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in idiopathic pulmonary fibrosis. Orthologous to human EHMT2 (euchromatic histone lysine methyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]

Ehmt2 Products(7)

mRNA	Protein	Name
NM_001286573.2	NP_001273502.1	histone-lysine N-methyltransferase EHMT2 isoform c
NM_147151.3	NP_671493.1	histone-lysine N-methyltransferase EHMT2 isoform b
NM_001403867.1	NP_001390796.1	histone-lysine N-methyltransferase EHMT2 isoform e
NM_145830.3	NP_665829.1	histone-lysine N-methyltransferase EHMT2 isoform a
NM_001403870.1	NP_001390799.1	histone-lysine N-methyltransferase EHMT2 isoform g
NM_001286575.2	NP_001273504.1	histone-lysine N-methyltransferase EHMT2 isoform d
NM_001403869.1	NP_001390798.1	histone-lysine N-methyltransferase EHMT2 isoform f

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables C2H2 zinc finger domain binding	IPI IPI: Inferred from physical interaction	16702210	MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	21402781	MGI
enables histone H3K27 methyltransferase activity	IDA IDA: Inferred from direct assay	15774718	MGI
enables histone H3K27 methyltransferase activity	IMP IMP: Inferred from mutant phenotype	17212651	MGI
enables histone H3K56 methyltransferase activity	IMP IMP: Inferred from mutant phenotype	22387026	MGI
enables histone H3K9 methyltransferase activity	EXP EXP: Inferred from Experiment	17707230	MGI
enables histone H3K9 methyltransferase activity	IDA IDA: Inferred from direct assay	15774718	MGI
enables histone H3K9 methyltransferase activity	IMP IMP: Inferred from mutant phenotype	15788566	MGI
enables promoter-specific chromatin binding	IDA IDA: Inferred from direct assay	22770845	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15774718	MGI
enables protein-lysine N-methyltransferase activity	IDA IDA: Inferred from direct assay	19144645	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA methylation-dependent heterochromatin formation	IDA IDA: Inferred from direct assay	18818694	MGI
acts upstream of or within behavioral response to cocaine	IMP IMP: Inferred from mutant phenotype	24584053	MGI
acts upstream of or within cellular response to cocaine	IDA IDA: Inferred from direct assay	24584053	MGI
acts upstream of or within fertilization	IMP IMP: Inferred from mutant phenotype	17599069	MGI
acts upstream of or within negative regulation of autophagosome assembly	IMP IMP: Inferred from mutant phenotype	23918802	MGI
acts upstream of or within negative regulation of gene expression via chromosomal CpG island methylation	IMP IMP: Inferred from mutant phenotype	17212651	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	17392792	MGI
acts upstream of or within neuron fate specification	IMP IMP: Inferred from mutant phenotype	24584053	MGI
acts upstream of or within oocyte development	IMP IMP: Inferred from mutant phenotype	17599069	MGI
acts upstream of or within organ growth	IMP IMP: Inferred from mutant phenotype	17599069	MGI
acts upstream of or within phenotypic switching	IMP IMP: Inferred from mutant phenotype	24584053	MGI
acts upstream of or within protein methylation	IMP IMP: Inferred from mutant phenotype	17599069	MGI
involved in regulation of DNA replication	IMP IMP: Inferred from mutant phenotype	22387026	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	17599069	MGI
acts upstream of or within spermatid development	IMP IMP: Inferred from mutant phenotype	17599069	MGI
acts upstream of or within synaptonemal complex assembly	IMP IMP: Inferred from mutant phenotype	17599069	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
NOT located in nucleolus	IDA IDA: Inferred from direct assay	16702210	MGI
located in nucleus	IDA IDA: Inferred from direct assay	15493016	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ehmt2 Protein Structure

PHA03247

EHMT_ZBD

ANKYR

ANK

Ank_2

ANK

Ank_2

ANK

SET_EHMT2

0
200
400
600
800
1000
1263 a.a.

Protein Preferred Names

Protein Names

histone-lysine N-methyltransferase EHMT2

H3-K9-HMTase 3	HLA-B associated transcript 8
histone H3-K9 methyltransferase 3	histone-lysine N-methyltransferase, H3 lysine-9 specific 3
protein G9a

Ehmt2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Ehmt2	Q9Z148	Hoxa9	Mus musculus	P09631	Anti Tag CoIP	24532712

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-16705	BRD4770	Inhibitor	99.69%	Unkown
HY-111904	EHMT2-IN-2	Inhibitor	≥99.0%	Unkown
HY-15647	BRD9539	Inhibitor	99.74%	Unkown
HY-111778	EHMT2-IN-1	Inhibitor	99.85%	Unkown
HY-161759	MS152	Inhibitor	99.36%	Unkown
HY-133031	CSV0C018875	Inhibitor	/	Unkown
HY-133031A	CSV0C018875 hydrochloride	Inhibitor	/	Unkown
HY-44062	G9a-IN-1	Inhibitor	98.12%	Unkown
HY-RS04230	EHMT2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS04231	Ehmt2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS04232	Ehmt2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ehmt2	NCBI	NCBI:10919

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