RAB35 - RAB35, member RAS oncogene family Gene

Homo sapiens

Also known as RAY; H-ray; RAB1C

Gene ID: 11021 | Gene type: protein coding

About RAB35

Cytogenetic location: 12q24.23 Genomic coordinates (GRCh38): 12:120,095,099-120,116,753 (from NCBI)

This gene has 6 transcripts (splice variants), 220 orthologues and 68 paralogues. Ubiquitous expression in spleen (RPKM 16.4), appendix (RPKM 14.7) and 25 other tissues.

Summary

Enables GTPase activity; guanyl ribonucleotide binding activity; and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in several processes, including endosomal transport; plasma membrane to endosome transport; and protein localization to endosome. Located in several cellular components, including clathrin-coated endocytic vesicle; clathrin-coated pit; and intercellular bridge. [provided by Alliance of Genome Resources, Apr 2022]

RAB35 Products(2)

mRNA	Protein	Name
NM_001167606.2	NP_001161078.1	ras-related protein Rab-35 isoform 2
NM_006861.7	NP_006852.1	ras-related protein Rab-35 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GDP binding	IDA IDA: Inferred from direct assay	20937701	GOA
enables GTP binding	IDA IDA: Inferred from direct assay	20937701	GOA
enables GTPase activity	IDA IDA: Inferred from direct assay	17562788	GOA
enables phosphatidylinositol-4,5-bisphosphate binding	IDA IDA: Inferred from direct assay	16950109	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17562788	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in antigen processing and presentation	IMP IMP: Inferred from mutant phenotype	19717423	GOA
involved in endosomal transport	IMP IMP: Inferred from mutant phenotype	16950109	GOA
involved in mitotic cytokinesis	IMP IMP: Inferred from mutant phenotype	16950109	GOA
involved in plasma membrane to endosome transport	IMP IMP: Inferred from mutant phenotype	17562788	GOA
involved in protein localization	IMP IMP: Inferred from mutant phenotype	16950109	GOA
involved in protein localization to endosome	IMP IMP: Inferred from mutant phenotype	21951725	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell projection membrane	IDA IDA: Inferred from direct assay	16950109	GOA
located in clathrin-coated endocytic vesicle	IDA IDA: Inferred from direct assay	16950109	GOA
located in clathrin-coated pit	IDA IDA: Inferred from direct assay	16950109	GOA
located in intercellular bridge	IDA IDA: Inferred from direct assay	16950109	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	16950109	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAB35 Protein Structure

Ras

0
100
201 a.a.

Protein Preferred Names

Protein Names

ras-related protein Rab-35

GTP-binding protein RAY

RAB35 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RAB35	Q15286	JPH3	Homo sapiens	Q8WXH2	Validated Y2H	32814053
Intra	RAB35	Q15286	JPH3	Homo sapiens	Q8WXH2	Y2H Array	32814053
Intra	RAB35	Q15286	JPH3	Homo sapiens	Q8WXH2	Y2H Pooling	32814053
Intra	RAB35	Q15286	MICALL1	Homo sapiens	Q8N3F8	Y2H	21951725
Intra	RAB35	Q15286	MICALL1	Homo sapiens	Q8N3F8	Anti Tag CoIP	21951725
Intra	RAB35	Q15286	DNM2	Homo sapiens	P50570-2	Validated Y2H	32814053
Intra	RAB35	Q15286	DNM2	Homo sapiens	P50570-2	Y2H Pooling	32814053
Intra	RAB35	Q15286	DNM2	Homo sapiens	P50570-2	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Familial Renal Oncocytoma

Lowe Oculocerebrorenal Syndrome

Lowe Syndrome	Oculocerebrorenal Syndrome
OCRL	Oculocerebrorenal Syndrome Of Lowe
Ocrl1	Phosphatidylinositol 4,5-Bisphosphate 5-Phosphatase Deficiency
Lowe Disease	Phosphatidylinositol 4,5-Biphosphate 5-Phosphatase Deficiency
Cerebrooculorenal Syndrome	Phosphatidylinositol-4,5-Bisphosphate-5-Phosphatase Deficiency
Lowe Oculo-Cerebro-Renal Dystrophy	Lowe Oculo-Cerebro-Renal Syndrome
Lowe Oculocerebrorenal Dystrophy	Low
Chromosome 11p Deletion Syndrome	Oculocerebrorenal Dystrophy
Cerebro-Oculorenal Dystrophy	Ocrl1 - [Oculocerebrorenal Syndrome]
Lowe-Terrey-Maclachlan Syndrome	Renal-Oculocerebrodystrophy

Deafness, Onychodystrophy, Osteodystrophy, Mental Retardation, And Seizures Syndrome

Door Syndrome	Doors Syndrome
Digitorenocerebral Syndrome	Autosomal Recessive Deafness-Onychodystrophy Syndrome
Deafness-Onychoosteodystrophy-Intellectual Disability Syndrome	DOORS
Drc Syndrome	Eronen Syndrome
Deafness-Onychodystrophy-Osteodystrophy-Intellectual Disability Syndrome	Brachydactyly Due To Absence Of Distal Phalanges
Deafness-Onychodystrophy-Osteodystrophy-Intellectual Disability-Seizures Syndrome	Deafness, Onychodystrophy, Osteodystrophy, And Mental Retardation Syndrome
Deafness-Oncychodystrophy-Osteodystrophy-Intellectual Disability Syndrome	Autosomal Recessive Hearing Loss-Onychodystrophy Syndrome
Hearing Loss-Onychodystrophy-Osteodystrophy-Intellectual Disability Syndrome	Hearing Loss-Onychodystrophy-Osteodystrophy-Intellectual Disability-Seizures Syndrome
Hearing Loss-Onychoosteodystrophy-Intellectual Disability Syndrome	Deafness, Onychodystrophy, Osteodystrophy, Intellectual Disability, And Seizures Syndrome
Deafness, Congenital Onychodystrophy, Recessive Form	Deafness, Onychodystrophy, Osteodystrophy, Mental Retardation Syndrome

Legionnaire Disease

Legionnaires' Disease	Legionnaires Disease
Legionnaire Disease, Susceptibility To	Legionella
Legionella Pneumonia	Infection By Legionella Pneumophilia
Legionnaire'S Disease	Legionellosis
Legionaire Disease, Susceptibility To	Legionnaires Pneumonia

Legionellosis

Legionella Infection	Pontiac Fever
Legionnaires' Disease	Infection By Legionella Pneumophilia
Legionella Pneumophila Infection

Warburg Micro Syndrome 1

Warburg Micro Syndrome	Micro Syndrome
Warbm	WARBM1
Warburg Sjo Fledelius Syndrome	Warburg-Sjo-Fledelius Syndrome
Micro Syndrome 1	Microcephaly, Microcornea, Congenital Cataract, Intellectual Disability, Optic Atrophy And Hypogenitalism

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11549	RAB35 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	RAB35	RGD	RGD:1306362
Felis catus	RAB35	VGNC	VGNC:107720
Canis familiaris	RAB35	VGNC	VGNC:45278
Bos taurus	RAB35	VGNC	VGNC:33644
Mus musculus	RAB35	MGD	MGI:1924657

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