RAB31 - RAB31, member RAS oncogene family Gene

Homo sapiens

Also known as Rab22B

Gene ID: 11031 | Gene type: protein coding

About RAB31

Cytogenetic location: 18p11.22 Genomic coordinates (GRCh38): 18:9,708,301-9,862,551 (from NCBI)

This gene has 12 transcripts (splice variants), 201 orthologues and 68 paralogues. Broad expression in brain (RPKM 65.3), adrenal (RPKM 60.7) and 22 other tissues.

Summary

Small GTP-binding proteins of the RAB family, such as RAB31, play essential roles in vesicle and granule targeting (Bao et al., 2002 [PubMed 11784320]).[supplied by OMIM, Jul 2009]

RAB31 Products(1)

mRNA	Protein	Name
NM_006868.4	NP_006859.2	ras-related protein Rab-31

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GDP binding	IDA IDA: Inferred from direct assay	17189207	GOA
enables GTP binding	IDA IDA: Inferred from direct assay	17189207	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	23055524	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in Golgi to plasma membrane protein transport	IMP IMP: Inferred from mutant phenotype	17678623	GOA
involved in cellular response to insulin stimulus	IMP IMP: Inferred from mutant phenotype	17189207	GOA
involved in phagosome maturation	IMP IMP: Inferred from mutant phenotype	21255211	GOA
involved in receptor internalization	IMP IMP: Inferred from mutant phenotype	19725050	GOA
involved in regulated exocytosis	IMP IMP: Inferred from mutant phenotype	17189207	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in early endosome	IDA IDA: Inferred from direct assay	17189207	GOA
located in phagocytic vesicle	IDA IDA: Inferred from direct assay	21255211	GOA
located in trans-Golgi network membrane	IDA IDA: Inferred from direct assay	17678623	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAB31 Protein Structure

Ras

0
100
195 a.a.

Protein Preferred Names

Protein Names

ras-related protein Rab-31

ras-related protein Rab-22B

RAB31 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RAB31	Q13636	NEK7	Homo sapiens	Q8TDX7	Y2H Array	32814053
Intra	RAB31	Q13636	NEK7	Homo sapiens	Q8TDX7	Y2H Pooling	32814053
Intra	RAB31	Q13636	NEK7	Homo sapiens	Q8TDX7	Validated Y2H	32814053
Intra	RAB31	Q13636	ALS2CL	Homo sapiens	Q60I27	Y2H Array	32296183
Intra	RAB31	Q13636	ALS2CL	Homo sapiens	Q60I27	Y2H Prey Pooling	32296183
Intra	RAB31	Q13636	ALS2CL	Homo sapiens	Q60I27	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant RAB31 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76561	RAB31 Protein, Human (His)	Q13636/NP_006859 (M1-C195)	≥95%

Related Diseases

Diseases

Alias

Choroid Cancer

Choroid Neoplasm	Choroidal Tumor
Malignant Tumor Of Choroid	Malignant Tumor Of The Choroid
Neoplasm Of Choroid	Choroid Neoplasms
Primary Malignant Neoplasm Of Choroid

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11544	RAB31 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	RAB31	MGD	MGI:1914603
Canis familiaris	RAB31	VGNC	VGNC:45274
Rattus norvegicus	RAB31	RGD	RGD:628598
Bos taurus	RAB31	VGNC	VGNC:33640
Macaca mulatta	RAB31	VGNC	VGNC:104239
Others	RAB31	NCBI

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