RIPK3 - receptor interacting serine/threonine kinase 3 Gene

Homo sapiens

Also known as RIP3

Gene ID: 11035 | Gene type: protein coding

About RIPK3

Cytogenetic location: 14q12 Genomic coordinates (GRCh38): 14:24,336,025-24,339,991 (from NCBI)

This gene has 7 transcripts (splice variants), 1 gene allele, 245 orthologues and 23 paralogues. Broad expression in small intestine (RPKM 12.2), duodenum (RPKM 10.4) and 21 other tissues.

Summary

The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from Other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce Apoptosis and weakly activate the NF-kappaB transcription factor. [provided by RefSeq, Jul 2008]

RIPK3 Products(1)

mRNA	Protein	Name
NM_006871.4	NP_006862.2	receptor-interacting serine/threonine-protein kinase 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	22817896	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19524512	GOA
enables protein kinase activity	IDA IDA: Inferred from direct assay	22265413	GOA
enables protein kinase activity	IMP IMP: Inferred from mutant phenotype	22817896	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	19524513	GOA
enables protein serine/threonine kinase activity	IMP IMP: Inferred from mutant phenotype	22265414	GOA
enables protein-containing complex binding	IMP IMP: Inferred from mutant phenotype	22265414	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in activation of protein kinase activity	IMP IMP: Inferred from mutant phenotype	22817896	GOA
involved in amyloid fibril formation	IMP IMP: Inferred from mutant phenotype	22817896	GOA
involved in necroptotic process	IMP IMP: Inferred from mutant phenotype	21737330	GOA
involved in necroptotic signaling pathway	IDA IDA: Inferred from direct assay	22265413	GOA
involved in necroptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	22265413	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IDA IDA: Inferred from direct assay	21931591	GOA
involved in positive regulation of necroptotic process	IDA IDA: Inferred from direct assay	22265414	GOA
involved in positive regulation of necroptotic process	IMP IMP: Inferred from mutant phenotype	22817896	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	22265413	GOA
is active in nucleus	IDA IDA: Inferred from direct assay	30271893	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	22817896	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RIPK3 Protein Structure

Pkinase

RHIM

0
100
200
300
400
518 a.a.

Protein Preferred Names

Protein Names

receptor-interacting serine/threonine-protein kinase 3

RIP-3	RIP-like protein kinase 3
receptor interacting protein 3

RIPK3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RIPK3	Q9Y572	MLKL	Homo sapiens	Q8NB16	Anti Tag CoIP	22265413
Intra	RIPK3	Q9Y572	MLKL	Homo sapiens	Q8NB16	Protein Kinase Assay	22265413
Intra	RIPK3	Q9Y572	MLKL	Homo sapiens	Q8NB16	Anti Tag CoIP	22265414
Cross	RIPK3	Q9Y572	ORF3a	Human SARS coronavirus	J9TC74	Confocal	30185776
Intra	RIPK3	Q9Y572	RIPK1	Homo sapiens	Q13546	Anti Tag CoIP	19524512
Intra	RIPK3	Q9Y572	RIPK1	Homo sapiens	Q13546	Anti Bait CoIP	22265414
Intra	RIPK3	Q9Y572	RIPK1	Homo sapiens	Q13546	Pull Down	22817896
Intra	RIPK3	Q9Y572	RIPK1	Homo sapiens	Q13546	Anti Tag CoIP	22265414
Intra	RIPK3	Q9Y572	RIPK1	Homo sapiens	Q13546	Anti Bait CoIP	22817896
Intra	RIPK3	Q9Y572	RIPK1	Homo sapiens	Q13546	Anti Tag CoIP	22265413
Intra	RIPK3	Q9Y572	ZBP1	Homo sapiens	Q9H171	Anti Tag CoIP	19590578

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant RIPK3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71855	RIPK3 Protein, Human (P.pastoris, His)	Q9Y572-1 (M1-K518)	≥95%

Related Diseases

Diseases

Alias

Caspase 8 Deficiency

Autoimmune Lymphoproliferative Syndrome Type 2b	Ceds
Alps2b	Caspase-8 Deficiency
Autoimmune Lymphoproliferative Syndrome, Type Iib	Alps With Recurrent Viral Infections
Autoimmune Lymphoproliferative Syndrome With Recurrent Viral Infections	Caspase 8 Deficiency Syndrome
Autoimmune Lymphoproliferative Syndrome Type Iib	Caspase Eight Deficiency State
CASP8D

Herpes Simplex

Herpes Simplex Infections	Herpesvirus Hominis Disease
Herpes Simplex Disease	Herpesviral Infection Due To Herpes Simplex
Infections Due To Simplex Virus	Herpes Nos

Autoimmune Lymphoproliferative Syndrome

ALPS	Canale-Smith Syndrome
Autoimmune Lymphoproliferative Syndrome, Type Ia	Autoimmune Lymphoproliferative Syndrome, Type Ib
Autoimmune Lymphoproliferative Syndrome Type 1, Autosomal Dominant	Css
Autoimmune Lymphoproliferative Syndrome, Type 1b	Autoimmune Lymphoproliferative Syndrome, Type 1a
Autoimmune Lymphoproliferative Syndrome, Type I, Autosomal Dominant	Fas Deficiency
Autoimmune Lymphoproliferative Syndrome 1a	ALPS1A
Autoimmune Lymphoproliferative Syndrome Type Ia	Autoimmune Lymphoproliferative Syndrome 1b
ALPS1B	Autoimmune Lymphoproliferative Syndrome Type Ib

Autoinflammation, Panniculitis, And Dermatosis Syndrome

Otulipenia	Otulin-Related Autoinflammatory Syndrome
AIPDS	Oras
Infantile-Onset Periodic Fever-Panniculitis-Dermatosis Syndrome	Autoinflammation, Panniculitis And Dermatosis Syndrome
Otulin Deficiency

Retinal Detachment

Retinal Detachments	Rhegmatogenous Retinal Detachment
Ruptured Retina With Detachment	Retinal Hole With Detachment

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-101872	GSK-872	Inhibitor	99.91%	Unkown
HY-101872A	GSK-872 hydrochloride	Inhibitor	99.21%	Unkown
HY-125402	GSK-843	Inhibitor	99.18%	Unkown
HY-158312	UH15-38	Inhibitor	99.80%	Unkown
HY-131064	RIPK3-IN-1	Inhibitor	99.19%	Unkown
HY-148365	NecroIr1	Activator	98.02%	Unkown
HY-148366	NecroIr2	Activator	98.99%	Unkown
HY-151873	SZM679	Inhibitor	99.59%	Unkown
HY-149052	SZM-1209	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	RIPK3	VGNC	VGNC:64642
Rattus norvegicus	RIPK3	RGD	RGD:628899
Mus musculus	RIPK3	MGD	MGI:2154952
Bos taurus	RIPK3	VGNC	VGNC:52818
Canis familiaris	RIPK3	VGNC	VGNC:110550
Others	RIPK3	NCBI

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