TPPP - tubulin polymerization promoting protein Gene

Homo sapiens

Also known as p24; p25; TPPP1; TPPP/p25; p25alpha

Gene ID: 11076 | Gene type: protein coding

About TPPP

Cytogenetic location: 5p15.33 Genomic coordinates (GRCh38): 5:659,862-700,727 (from NCBI)

This gene has 1 transcript (splice variant), 192 orthologues and 2 paralogues. Biased expression in brain (RPKM 45.7), lung (RPKM 7.7) and 9 other tissues.

Summary

Enables several functions, including GTPase activity; magnesium ion binding activity; and protein homodimerization activity. Involved in several processes, including microtubule Cytoskeleton organization; negative regulation of tubulin deacetylation; and positive regulation of protein polymerization. Located in several cellular components, including mitochondrion; mitotic spindle; and perinuclear region of cytoplasm. Colocalizes with microtubule and microtubule bundle. [provided by Alliance of Genome Resources, Apr 2022]

TPPP Products(1)

mRNA	Protein	Name
NM_007030.3	NP_008961.1	tubulin polymerization-promoting protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GTPase activity	IDA IDA: Inferred from direct assay	21316364	GOA
enables magnesium ion binding	IDA IDA: Inferred from direct assay	21316364	GOA
enables microtubule nucleator activity	IDA IDA: Inferred from direct assay	31522887	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15590652	GOA
enables protein dimerization activity	IDA IDA: Inferred from direct assay	22484033	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	26289831	GOA
enables tubulin binding	IDA IDA: Inferred from direct assay	17105200	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in astral microtubule organization	IDA IDA: Inferred from direct assay	22328514	GOA
involved in microtubule bundle formation	IDA IDA: Inferred from direct assay	17105200	GOA
involved in microtubule nucleation by microtubule organizing center	IDA IDA: Inferred from direct assay	31522887	GOA
involved in microtubule polymerization	IDA IDA: Inferred from direct assay	18028908	GOA
involved in negative regulation of tubulin deacetylation	IDA IDA: Inferred from direct assay	20308065	GOA
involved in positive regulation of protein polymerization	IDA IDA: Inferred from direct assay	15590652	GOA
involved in regulation of microtubule cytoskeleton organization	IDA IDA: Inferred from direct assay	23093407	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in Golgi apparatus	IDA IDA: Inferred from direct assay	31522887	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	18028908	GOA
colocalizes with microtubule	IDA IDA: Inferred from direct assay	18028908	GOA
colocalizes with microtubule bundle	IDA IDA: Inferred from direct assay	17105200	GOA
located in mitotic spindle	IDA IDA: Inferred from direct assay	22328514	GOA
located in nucleus	IDA IDA: Inferred from direct assay	18028908	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	15590652	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TPPP Protein Structure

p25-alpha

0
100
200
219 a.a.

Protein Preferred Names

Protein Names

tubulin polymerization-promoting protein

25 kDa brain-specific protein

TPPP Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TPPP	O94811	ZNF114	Homo sapiens	Q8NC26	Validated Y2H	32296183
Intra	TPPP	O94811	H1-1	Homo sapiens	Q02539	Crosslink	30021884
Intra	TPPP	O94811	SNCA	Homo sapiens	P37840	ELISA	27671864
Intra	TPPP	O94811	SNCA	Homo sapiens	P37840	CD	27671864
Intra	TPPP	O94811	SNCA	Homo sapiens	P37840	NMR	27671864
Intra	TPPP	O94811	SNCA	Homo sapiens	P37840	BiFC	27671864

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Intellectual Developmental Disorder, Autosomal Dominant 3

MRD3	Autosomal Dominant Non-Syndromic Intellectual Disability 3
Mental Retardation, Autosomal Dominant 3	Autosomal Dominant Intellectual Developmental Disorder 3

Striatonigral Degeneration

Multiple Sclerosis

MS	Multiple Sclerosis, Susceptibility To
Disseminated Sclerosis	Multiple Sclerosis, Disease Progression, Modifier Of
Insular Sclerosis	Multiple Sclerosis Modifier Of Disease Progression
Multiple Sclerosis, Susceptibility To 1	Multiple Sclerosis, Susceptibility To, 1
Multiple Sclerosis 1	Generalized Multiple Sclerosis
Multiple Sclerosis Variant	Multiple Sclerosis Susceptibility To
Cerebrospinal Sclerosis	Generalised Multiple Sclerosis
Ms - [Multiple Sclerosis]	Disseminated Cerebrospinal Sclerosis
Disseminated Multiple Sclerosis	Disseminated Nervous System Myelosclerosis
Multiple Cerebrospinal Sclerosis	Multiple Combined Sclerosis
Multiple Sclerosis Generalised	Disseminated Brain Sclerosis
Disseminated Spinal Sclerosis	Insular Brain Sclerosis
Miliary Brain Sclerosis	Multiple Combined Sclerosis Of Spinal Cord
Multiple Ascending Sclerosis	Multiple Brain Sclerosis
Multiple Sclerosis Of Brain Stem	Multiple Sclerosis Of The Brain Stem
Multiple Sclerosis Of Cord	Sclérose En Plaques
Plaque Sclerosis	Multiple Sclerosis Of The Spinal Cord

Olivopontocerebellar Atrophy

Thomas Syndrome	Olivopontocerebellar Atrophies
Dejerine-Thomas Syndrome	Thomas' Syndrome
Wadia-Swami Syndrome	Opca
Potter Sequence-Cleft Lip/Palate-Cardiopathy Syndrome	Spinocerebellar Ataxia Type 2

Schizophrenia 13

SCZD13	Schizophrenia Susceptibility Locus, Chromosome 15q13-Q14-Related
Schizophrenia, Susceptibility To, 13

Multiple System Atrophy 1

Multiple System Atrophy	Shy-Drager Syndrome
Msa	MSA1
Multiple System Atrophy 1, Susceptibility To	Sporadic Olivopontocerebellar Atrophy
Multisystem Atrophy	Msa1, Susceptibility To
Multiple System Atrophy, Susceptibility To	Opca
Progressive Autonomic Failure With Multiple System Atrophy	Sds

Dementia, Lewy Body

Lewy Body Dementia	Lewy Body Disease
Diffuse Lewy Body Disease	Dementia With Lewy Bodies
DLB	Autosomal Dominant Diffuse Lewy Body Disease
Cortical Lewy Body Disease	Dementia, Lewy Body, Susceptibility To
Lewy Body Dementia, Susceptibility To	Senile Dementia Of The Lewy Body Type
Dementia Of The Lewy Body Type	Lbd
Diffuse Lewy Body Disease With Gaze Palsy	Dysphasic Dementia Hereditary
Lewy Body Type Senile Dementia	Lewy Body Variant Of Alzheimer Disease
Lewy Bodies	Lewy Body
Dlbd - [Diffuse Lewy Body Disease]	Clbd - [Cortical Lewy Body Disease]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14944	TPPP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14945	TPPP3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TPPP	VGNC	VGNC:102351
Bos taurus	TPPP	VGNC	VGNC:36258
Mus musculus	TPPP	MGD	MGI:1920198
Canis familiaris	TPPP	VGNC	VGNC:47749
Rattus norvegicus	TPPP	RGD	RGD:1310121
Others	TPPP	NCBI

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