2. Gene
  3. H1-1 - H1.1 linker histone, cluster member Gene

H1-1 - H1.1 linker histone, cluster member Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as H1A; H1.1; H1F1; HIST1; HIST1H1A

Gene ID: 3024 | Gene type: protein coding

About H1-1

Cytogenetic location: 6p22.2 Genomic coordinates (GRCh38): 6:26,017,032-26,017,787 (from NCBI)

This gene has 1 transcript (splice variant), 79 orthologues and 9 paralogues.

Summary

Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]

H1-1 Products(1)

mRNA Protein Name
NM_005325.4 NP_005316.1 histone H1.1
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables chromatin DNA binding IMP
IMP: Inferred from mutant phenotype
15911621 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19895577 GOA
Cellular Component GO Annotation Evidence Reference Source
located in chromatin IDA
IDA: Inferred from direct assay
19882353 GOA
located in euchromatin IDA
IDA: Inferred from direct assay
15911621 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

H1-1 Protein Structure

Linker_histone

Linker_histone: linker histone H1 and H5 family (41 - 112)

  • 0
  • 100
  • 200
  • 215 a.a.
Protein Preferred Names Protein Names

histone H1.1

H1 histone family, member 1

Related Diseases

Diseases Alias
Tonsil Squamous Cell Carcinoma

Tonsillar Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Palatine Tonsil
Narcissistic Personality Disorder
Paraphilia Disorder

Paraphilia

Paraphilias
Cartilage-Hair Hypoplasia

Metaphyseal Chondrodysplasia, Mckusick Type

CHH

Mckusick Type Metaphyseal Chondrodysplasia

Metaphyseal Dysplasia Without Hypotrichosis

Cartilage Hair Hypoplasia Like Syndrome

Metaphyseal Chondrodysplasia Mckusick Type

Chhv

Cartilage-Hair Hypoplasia Variant, Skeletal Manifestations Only

Cartilage-Hair Hypoplasia-Like Skeletal Dysplasia Without Hypotrichosis Or Immunodeficiency

Cartilage-Hair Syndrome

Mckusick'S Metaphyseal Chondrodysplasia Syndrome

Metaphyseal Chondrodysplasia, Recessive Type

Autosomal Recessive Metaphyseal Chondrodysplasia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (10)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-18340 (R)​-​CR8 99.61% Unkown
HY-18340A (R)-CR8 trihydrochloride 98.95% Unkown
HY-N9331 Cimicifugoside H-1 98.87% Unkown
HY-123230S Trifloxystrobin-d6 Inhibitor / Unkown
HY-135180 1H-1-Ethyl Candesartan Cilexetil / Unkown
HY-143907S Atorvastatin EP impurity H-d5 / Unkown
HY-162679 c-Met degrader-1 / Unkown
HY-RS05945 H1-1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-117146 Indoxacarb / Unkown
HY-79648S Fmoc-Methylalanine-d3 / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus H1-1 VGNC VGNC:109855
Mus musculus H1-1 MGD MGI:1931523
Canis familiaris H1-1 VGNC VGNC:83712
Bos taurus H1-1 VGNC VGNC:83548
Rattus norvegicus H1-1 RGD RGD:1305706
Macaca mulatta H1-1 VGNC VGNC:109665