RCAN3 - RCAN family member 3 Gene

Homo sapiens

Also known as RCN3; MCIP3; hRCN3; DSCR1L2

Gene ID: 11123 | Gene type: protein coding

About RCAN3

Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38): 1:24,502,344-24,541,040 (from NCBI)

This gene has 10 transcripts (splice variants), 203 orthologues and 2 paralogues. Broad expression in prostate (RPKM 18.2), lymph node (RPKM 9.0) and 22 other tissues.

Summary

Enables Phosphatase binding activity and troponin I binding activity. Predicted to be involved in calcium-mediated signaling. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

RCAN3 Products(10)

mRNA	Protein	Name
NM_001251977.2	NP_001238906.1	calcipressin-3 isoform 1
NM_001251978.1	NP_001238907.1	calcipressin-3 isoform 1
NM_001251979.2	NP_001238908.1	calcipressin-3 isoform 1
NM_001251980.1	NP_001238909.1	calcipressin-3 isoform 2
NM_001251981.2	NP_001238910.1	calcipressin-3 isoform 3
NM_001251982.1	NP_001238911.1	calcipressin-3 isoform 4
NM_001251983.2	NP_001238912.1	calcipressin-3 isoform 5
NM_001251984.2	NP_001238913.1	calcipressin-3 isoform 5
NM_001251985.1	NP_001238914.1	calcipressin-3 isoform 6
NM_013441.4	NP_038469.1	calcipressin-3 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables phosphatase binding	IPI IPI: Inferred from physical interaction	26248042	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16516408	GOA
enables troponin I binding	IPI IPI: Inferred from physical interaction	16516408	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RCAN3 Protein Structure

Calcipressin

0
100
200
241 a.a.

Protein Preferred Names

Protein Names

calcipressin-3

Down syndrome candidate region 1-like 2

RCAN3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	RCAN3	Q9UKA8	P0C6X7-PRO_0000037309	Human SARS coronavirus	P0C6X7-PRO_0000037309	Y2H Pooling	22046132
Cross	RCAN3	Q9UKA8	P0C6X7-PRO_0000037309	Human SARS coronavirus	P0C6X7-PRO_0000037309	Lumier	22046132
Intra	RCAN3	Q9UKA8	TRIM23	Homo sapiens	P36406	Y2H Array	32296183
Intra	RCAN3	Q9UKA8	GRB10	Homo sapiens	Q13322	Y2H Array	25814554
Intra	RCAN3	Q9UKA8	GRB10	Homo sapiens	Q13322	Lumier	25814554

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Down Syndrome

Trisomy 21	Complete Trisomy 21 Syndrome
Down'S Syndrome	Trisomy 21 Syndrome
Down'S Syndrome - Trisomy 21	Downs Syndrome
G Trisomy	47,Xx,+21
47,Xy,+21	Trisomy G
Down Syndrome, Susceptibility To	Chromosome 21 Trisomy
Trisomy 21 Nos	Abnormal Autosomes 21

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11781	RCAN3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	RCAN3	VGNC	VGNC:45438
Mus musculus	RCAN3	MGD	MGI:1858220
Macaca mulatta	RCAN3	VGNC	VGNC:76875
Rattus norvegicus	RCAN3	RGD	RGD:1311826
Bos taurus	RCAN3	VGNC	VGNC:33822

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