2. Gene
  3. TRIM23 - tripartite motif containing 23 Gene

TRIM23 - tripartite motif containing 23 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ARD1; ARFD1; RNF46

Gene ID: 373 | Gene type: protein coding

About TRIM23

Cytogenetic location: 5q12.3 Genomic coordinates (GRCh38): 5:65,589,690-65,624,333 (from NCBI)

This gene has 7 transcripts (splice variants), 207 orthologues and 30 paralogues. Ubiquitous expression in brain (RPKM 18.0), prostate (RPKM 7.0) and 24 other tissues.

Summary

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein is also a member of the ADP ribosylation factor family of guanine nucleotide-binding family of proteins. Its carboxy terminus contains an ADP-ribosylation factor domain and a guanine nucleotide binding site, while the amino terminus contains a GTPase activating protein domain which acts on the guanine nucleotide binding site. The protein localizes to lysosomes and the Golgi apparatus. It plays a role in the formation of intracellular transport vesicles, their movement from one compartment to another, and phopholipase D activation. Three alternatively spliced transcript variants for this gene have been described. [provided by RefSeq, Jul 2008]

TRIM23 Products(3)

mRNA Protein Name
NM_001656.4 NP_001647.1 E3 ubiquitin-protein ligase TRIM23 isoform alpha
NM_033227.3 NP_150230.1 E3 ubiquitin-protein ligase TRIM23 isoform beta
NM_033228.3 NP_150231.1 E3 ubiquitin-protein ligase TRIM23 isoform gamma

TRIM23 Protein Structure

zf-B_box

zf-B_box: B-box zinc finger (125 - 168)

Arf

Arf: ADP-ribosylation factor family (400 - 564)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 574 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase TRIM23

ADP-ribosylation factor domain protein 1, 64kDa

Related Diseases

Diseases Alias
Immunodeficiency 33

IMD33

X-Linked Mendelian Susceptibility To Mycobacterial Diseases Due To Ikbkg Deficiency

X-Linked Mendelian Susceptibility To Mycobacterial Diseases Due To Nemo Deficiency

X-Linked Msmd Due To Ikbkg Deficiency

X-Linked Msmd Due To Nemo Deficiency

Invasive Pneumococcal Disease, Recurrent Isolated, 2

Invasive Pneumococcal Disease, Recurrent Isolated, 2, Formerly

Ipd2, Formerly

Nf-Kappa B Essential Modulator Deficiency

Familial X-Linked 1 Atypical Mycobacteriosis

Nemo Deficiency Syndrome

Amcbx1

Familial, X-Linked, Atypical Mycobacteriosis 1

Ipd2

Recurrent Isolated Invasive Pneumococcal Disease 2

X-Linked Disseminated Atypical Mycobacterial Infection Type 1

X-Linked Immunodeficiency 33, Mycobacteriosis

X-Linked Susceptibility To Mycobacterial Disease Type 1

Invasive Pneumococcal Disease, Recurrent Isolated, Type 2

Atypical Mycobacteriosis, Familial, X-Linked 1
Mulibrey Nanism

MUL

Muscle-Liver-Brain-Eye Nanism

Pericardial Constriction And Growth Failure

Perheentupa Syndrome

Mulibrey Growth Disorder

Mulibrey Nanism Syndrome

Pericardial Constriction With Growth Failure

Nanism Mulibrey
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15028 TRIM23 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus TRIM23 VGNC VGNC:36320
Macaca mulatta TRIM23 VGNC VGNC:79962
Mus musculus TRIM23 MGD MGI:1933161
Canis familiaris TRIM23 VGNC VGNC:47809
Rattus norvegicus TRIM23 RGD RGD:621587
Felis catus TRIM23 VGNC VGNC:68048